Bhakti S. Halkude

ORCID: 0009-0003-1444-055X
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Chemistry and Chemical Engineering
  • Injection Molding Process and Properties
  • Process Optimization and Integration
  • Drug Solubulity and Delivery Systems
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Analytical Methods in Pharmaceuticals
  • Manufacturing Process and Optimization
  • Scheduling and Optimization Algorithms
  • Flexible and Reconfigurable Manufacturing Systems
  • Computational Drug Discovery Methods
  • Crystallization and Solubility Studies

Marinus Pharmaceuticals (United States)
2023

Novartis-MIT Center for Continuous Manufacturing
2017

Massachusetts Institute of Technology
2017

The pharmaceutical industry faces multiple challenges (e.g., inefficient manufacturing techniques, quality control issues, and supply chain vulnerabilities) because of its current batch-wise approach to manufacturing. Recent regulatory support for continuous advances in process technologies have caused an increase interest from some drug manufacturers modernize their production processes. However, many these companies focused on hybrid processes, where only certain steps are continuous,...

10.1021/acs.oprd.0c00383 article EN Organic Process Research & Development 2020-10-21

We report here a fully automated, end-to-end, integrated continuous manufacturing process for small-molecule generic medication with built-in quality assurance. The entire fits into box of 30.7 m2 modular footprint and total residence time less than 30 h, throughput up to 40.3 × 106 tablets per year.

10.1039/c9cc06945c article EN Chemical Communications 2019-12-09

Abstract A predictive mathematical model for tablet dissolution was developed and implemented in an end‐to‐end integrated continuous manufacturing pilot plant. The tablets were produced immediate release with a proprietary extrusion‐molding‐coating (EMC) unit operation. Besides the mass balance of API solute buffer solution, consisted dissolution, diffusion, population particles swollen tablet, which mainly controlled by swelling erosion polymeric excipient matrix. An equivalence study...

10.1002/aic.18124 article EN AIChE Journal 2023-05-26
Coming Soon ...