A5014921870- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Sexual Differentiation and Disorders
- Nanocomposite Films for Food Packaging
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Radiation Therapy and Dosimetry
- Radiopharmaceutical Chemistry and Applications
- Protein Hydrolysis and Bioactive Peptides
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tissue Engineering and Regenerative Medicine
- Ovarian function and disorders
- Prostate Cancer Diagnosis and Treatment
- Microencapsulation and Drying Processes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Phagocytosis and Immune Regulation
- Ocular Diseases and Behçet’s Syndrome
- Analytical chemistry methods development
- CAR-T cell therapy research
- Mycotoxins in Agriculture and Food
- Bone Tissue Engineering Materials
- Laser Applications in Dentistry and Medicine
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Occupational and environmental lung diseases
Imperial College London
2023-2024
Islamic Azad University of Tabriz
2015-2024
Islamic Azad University, Isfahan
2024
Haukeland University Hospital
2023
Institute of Cancer Research
2016-2018
University of California, San Francisco
2018
Biotechnology Research Center
2017
Iran Nanotechnology Initiative Council
2015-2017
Tabriz University of Medical Sciences
2017
University of Tabriz
2015
Abstract Purpose: CHD1 deletions and SPOP mutations frequently cooccur in prostate cancer with lower frequencies reported castration-resistant (CRPC). We monitored expression during disease progression assessed the molecular clinical characteristics of CHD1-deleted/SPOP-mutated metastatic CRPC (mCRPC). Experimental Design: identified 89 patients mCRPC who had hormone-naive tumor samples available: These were analyzed for CHD1, PTEN, ERG by IHC. status was determined targeted next-generation...
Deletion of the chromatin remodeler chromodomain helicase DNA-binding protein 1 (CHD1) is a common genomic alteration found in human prostate cancers (PCas). CHD1 loss represents distinct PCa subtype characterized by SPOP mutation and higher instability. However, role development vivo its clinical utility remain unclear.To study management, we generated genetically engineered mouse model with prostate-specific deletion murine Chd1 as well isogenic wild-type homozygous deleted benign lines....
Obesity-related hypogonadotropic hypogonadism is a well-characterized condition in men (termed male obesity-related secondary hypogonadism; MOSH); however, an equivalent has not been as clearly described women. The prevalence of polycystic ovary syndrome (PCOS) known to increase with obesity, but PCOS more typically characterized by increased gonadotropin-releasing hormone (GnRH) (and proxy luteinizing hormone; LH) pulsatility, rather than the reduced gonadotropin levels observed MOSH....
Abstract In recent years, development of biopolymeric nanofibers as an active biodegradable packaging system has attracted specific attention. The objective this research was to develop zein‐based electrospun (NFs) incorporated with geraniol‐loaded nanoliposomes (G‐loaded NLPs). Geraniol encapsulated into NLPs efficiency 79.23%. particle size and zeta potential G‐loaded were 121.50 nm −38.30 mV, respectively. successful loading geraniol in the approved by Fourier transform infrared (FT‐IR)...
Idiopathic pulmonary fibrosis (IPF) is a genetically mediated, age-associated, progressive form of characterised pathologically by usual interstitial pneumonia (UIP) pattern fibrosis. The UIP also found in attributable to clinical diagnoses other than IPF (non-IPF UIP), whose course similarly poor, suggesting common molecular drivers. This study investigates whether and non-IPF lungs express markers telomere dysfunction senescence.To test patients with share drivers, lung tissues from 169 57...
Introduction: The aim of this study was to evaluate the methylation status TNF-α and SOCS3 promoters in patients with BD compare them a healthy group.Method: This case–control study, which 47 subjects 61 individuals as control participated. Blood samples were collected from all participants. Then, PBMCs isolated using Ficoll method considered sites investigated qMS-PCR technique after DNA extraction by rapid genomic its analysis Nano-drop.Results: expression showed that level significantly...
Objectives: This study assessed the effects of two remineralizing agents namely MI Paste Plus containing casein phosphopeptide amorphous calcium phosphate fluoride (CPP-ACFP) and Remin Pro hydroxyapatite, xylitol (HFX) with/without erbium-doped yttrium aluminium garnet (Er:YAG) CO2 laser irradiation on demineralized enamel microhardness.
 Materials Methods: In this in vitro study, 70 sound human premolars were mesiodistally sectioned, at a pH 4.6 for 8 hours, randomly divided into 7...
To understand whether there was an association between very young oocyte donors and adverse outcomes, this a single centre retrospective study (Lister Fertility Clinic, London) examining data collected 1st January 2010 31st December 2021. A total of 1,182 were included in the final analysis. Data categorised by donor age years; ≤22, 23–25, 26–28, 29–31, 32–34. Statistical analysis performed using SPSS. Donors aged ≤22 years showed increased live birth rates (LBR) fresh In Vitro Fertilisation...
<b>Background:</b> Idiopathic pulmonary fibrosis (IPF) is an age-associated, progressive form of characterized pathologically by a usual interstitial pneumonia (UIP) pattern fibrosis. The UIP also found in attributable to clinical diagnoses other than IPF (Non-IPF UIP) whose course similarly poor, suggesting common molecular drivers. <b>Methods:</b> To test whether patients with and non-IPF share drivers, lung tissue from 169 57 were histopathologically molecularly compared. <b>Results:</b>...
Abstract Adenocarcinomas of the prostate consist a collection malignancies with distinct molecular underpinnings. Linking background to clinical behaviour, i.e. tumour progression and response therapy has not yet been fully established. This is in large measure due paucity well-annotated patient cohorts, which cover evolution from localized, hormone naïve metastatic castration resistant cancer. Deletions gene Chromodomain Helicase DNA Binding Protein 1 (CHD1) are among most frequent genomic...