A5048270043- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- RNA Research and Splicing
- Ginseng Biological Effects and Applications
- Drug-Induced Hepatotoxicity and Protection
- Pediatric Hepatobiliary Diseases and Treatments
- Berberine and alkaloids research
- Statistical Methods in Clinical Trials
- Bone health and treatments
- Pharmacological Effects of Natural Compounds
- Bone Metabolism and Diseases
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Flavonoids in Medical Research
- Bone health and osteoporosis research
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Metabolism, Diabetes, and Cancer
- Cancer Mechanisms and Therapy
- Cancer Treatment and Pharmacology
- Chronic Kidney Disease and Diabetes
- RNA regulation and disease
- Antiplatelet Therapy and Cardiovascular Diseases
- Chromatin Remodeling and Cancer
Shandong University of Traditional Chinese Medicine
2025
Huazhong University of Science and Technology
2021-2024
Tongji Hospital
2021-2024
Shaanxi University of Technology
2020
Ginseng (Panax ginseng C. A. Mey) is a common traditional Chinese medicine used for anti-inflammation, treating colitis, type 2 diabetes, diarrhea, and recovering hepatobiliary function. Ginsenosides, the main active components isolated from ginseng, possess liver gallbladder diseases therapeutic potential. Cholestatic injury (CLI) disease induced by intrahepatic accumulation of toxic bile acids currently lacks clinically effective drugs. Our previous study found that ginsenosides alleviated...
Chondroitin sulfate (CS) has antioxidative, anti-inflammatory, anti-osteoarthritic and hypoglycemic effects. However, whether it antidiabetic osteoporosis effects not been reported. Therefore, in this study, we established a STZ-induced diabetic rat model; CS (500 mg kg−1 d−1) was orally administrated for eight weeks to study its preventive on osteoporosis. The results showed that of treatment improved the symptoms diabetes; CS-treated group increased body weight, decreased water or food...
<title>Abstract</title> Pro-angiogenic factors play a crucial role in the treatment of malignant tumors, particularly anti-angiogenic therapies. This study evaluated vascular and lymphatic adverse events (AEs) associated with four anti-tumor angiogenesis drugs WHO-VigiAccess database. It also compared drug reaction (ADR) profiles these to support personalized decisions optimize therapeutic benefits safety. <bold>Methods</bold>:This was designed as descriptive retrospective analysis. Adverse...
Estrogens have been reported to cause dysfunction in biliary transport systems, thereby inducing cholestasis. Multidrug resistance-associated protein 2 (MRP2) is a transporter responsible for independent bile flow. Emerging evidence indicates that PDZ domain containing 1 (PDZK1) regulates localization of MRP2; however, PDZK1’s role and regulatory machinery MRP2-mediated estrogen-induced cholestasis (EIC) remain unclear. Herein, mouse model EIC, we observed downregulated PDZK1 expression the...
Intrahepatic cholestasis (IC) occurs when the liver and systemic circulation accumulate bile components, which can then lead to lipid metabolism disorders oxidative damage. Ginsenosides (GS) are pharmacologically active plant products derived from ginseng that possesses lipid-regulation antioxidation activities. The purpose of this study was evaluate possible protective effects ginsenosides on homeostasis disorder stress in mice with alpha-naphthylisothiocyanate (ANIT)-induced IC investigate...
Hyperglycemia, increased inflammation, and mitochondrial dysfunction in diabetes may eventually cause kidney damage. Black rice cyanidin-3-glucoside has anti-hyperglycemic anti-osteoporosis effects. Whether it preventive effects on renal not been reported. In this study, a rat model of diabetic nephropathy was established, administered for 56 days, lisinopril as the positive control. The research found that black supplementation decreased glucose, prevented insulin resistance, repaired...
Highlights•Huaier can be an effective drug to reduce oxaliplatin-induced hepatotoxicity.•ROS-mediated oxidative stress is involved in hepatotoxicity.•Huaier relieves liver stress.•Inhibition of PI3K pathway reverses the hepatoprotective effect Huaier.AbstractHepatotoxicity caused by anticancer medication oxaliplatin (OXA) significantly restricts its clinical use and raises risk damage. Huaier, a fungus found China, has been demonstrated have various beneficial effects adjuvant therapy for...
Intrahepatic cholestasis (IC) is a liver disease caused by disorders in bile formation and excretion, owing to structural functional abnormalities hepatocytes and/or capillaries. IC commonly hepatitis virus, alcohol consumption, drug-induced damage, autoimmune heredity. In the absence of effective treatment, can progress fibrosis, cirrhosis ultimately failure. However, mechanisms underlying remain poorly understood. believed be closely associated with changes transcription, function...
Baicalin, an important flavonoid isolated from Scutellaria baicalensis Georgi, is a Chinese herb widely used in clinical practice. We previously reported the vivo accumulation of baicalin rats with intrahepatic cholestasis (IHC) after single dose. However, effects long-term administration on its pharmacokinetics are unknown. Thus, we investigated disposition normal and those IHC multiple consecutive administrations. In addition, further effect multidrug resistance protein 2 (MRP2) to explore...
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Ethnopharmacological relevance: Natural Calculus Bovis (NCB) is a traditional Chinese medicine used for anti-inflammation, treating fever, pain, sedation, and recovering hepatobiliary function. Sativus (CBS), produced from in vitro artificial cultivation by bioengineering techniques, acts as an ideal substitute NCB when various diseases. Aim of the study: Gut-liver injury important pathological feature several cholestatic liver diseases, including estrogen-induced cholestasis (EIC). The...