A5064850630- Ureteral procedures and complications
- Enhanced Recovery After Surgery
- Telomeres, Telomerase, and Senescence
- Mitochondrial Function and Pathology
- Latin American and Latino Studies
- Genetics, Aging, and Longevity in Model Organisms
- Pelvic floor disorders treatments
University of Toronto
2019-2025
Sunnybrook Research Institute
2014
Sunnybrook Health Science Centre
2014
Health Sciences Centre
2014
Here we show that transgenic expression of miR-17 extends lifespan and inhibits cellular senescence. We propose acts as a critical regulator senescence tumorigenesis. demonstrate targets both ADCY5 IRS1, upregulating the downstream signals MKP7, FoxO3, LC3B, HIF1α, downregulating mTOR, c-myc, cyclin D1, JNK. Silencing either or IRS1 promoted autophagy repressed apoptosis. Repression by translocated membrane-bound RGS2 into nucleus, promoting interactions with HIF1α MKP7 promoter, enhancing...