A5102888895- Protein Structure and Dynamics
- Computational Drug Discovery Methods
- Monoclonal and Polyclonal Antibodies Research
- Advanced Memory and Neural Computing
- Photosynthetic Processes and Mechanisms
- Pharmacological Effects of Natural Compounds
- Neurobiology and Insect Physiology Research
- Phase-change materials and chalcogenides
- Neural Networks and Reservoir Computing
- Microtubule and mitosis dynamics
- Photoreceptor and optogenetics research
- Click Chemistry and Applications
- Plant Molecular Biology Research
- Nanopore and Nanochannel Transport Studies
- Advanced Electron Microscopy Techniques and Applications
- Neural dynamics and brain function
- Ubiquitin and proteasome pathways
- CCD and CMOS Imaging Sensors
- Plant biochemistry and biosynthesis
- Cancer-related Molecular Pathways
- Advanced Fluorescence Microscopy Techniques
- Neuroscience and Neural Engineering
- Plant Reproductive Biology
- Nonlinear Optical Materials Studies
- Quantum Dots Synthesis And Properties
Anhui University
2024-2025
Beijing National Laboratory for Molecular Sciences
2016-2024
Peking University
2016-2024
Shanghai Institute of Optics and Fine Mechanics
2024
Chinese Academy of Sciences
2024
State Key Laboratory for Structural Chemistry of Unstable and Stable Species
2016-2020
In flowering plants, fertilization requires complex cell-to-cell communication events between the pollen tube and female reproductive tissues, which are controlled by extracellular signaling molecules interacting with receptors at surface. We found that two such in Arabidopsis, BUPS1 BUPS2, their peptide ligands, RALF4 RALF19, tube-expressed required to maintain integrity. BUPS2 interact ANXUR1 ANXUR2 via ectodomains, both sets of bind RALF19. These receptor-ligand interactions competition...
Intrinsically disordered proteins or intrinsically regions (IDPs) have gained much attention in recent years due to their vital roles biology and prevalence various human diseases. Although IDPs are perceived as attractive therapeutic targets, rational drug design targeting remains challenging because of conformational heterogeneity. Here, we propose a hierarchical computational strategy for IDP virtual screening (IDPDVS) applied it the discovery p53 transactivation domain I (TAD1) binding...
Abstract Though many studies have been performed to elucidate molecular mechanism of traditional Chinese medicines (TCMs) by identifying protein-compound interactions, no systematic analysis at herb level was reported. TCMs are prescribed herbs and all compounds from a certain should be considered as whole, thus may provide comprehensive understanding TCMs. Here, we proposed computational strategy study TCM used it analyze anti-HIV formula. Herb-target network carried out between 17...
Abstract Artificial neurons with leaky rectified linear unit (L‐ReLU) function can effectively process negative information, enhancing the neuromorphic systems capbility to handle values. Memristive devices show great potential in building compact and bio‐plausible artificial neurons, however, a neuron device that supports L‐ReLU functions is still lacking. In this work, proposed based on bipolar asymmetrical diffusive memristor. Utilizing intercalation leveraging migration diffusion ratio...
Abstract In statistical mechanics, it is well known that the huge number of degrees freedom does not complicate problem as seems, but actually greatly simplifies analysis (e.g., to give a Boltzmann distribution). Here, we reveal ensemble averaging from vast conformations intrinsically disordered proteins (IDPs) nature binding affinity, which can be reliably decomposed into sum ligandability IDP and capacity ligand. Such an unexpected regularity applied facilitate virtual screening upon IDPs....
An ITO/PMMA/SiC-NWs/ITO device enables visual adaptation in vision systems. Integrated with an LIF circuit, it reflects via frequency changes. In extreme weather, this system accuracy reached 97%, 12% higher than traditional
Polo-like kinase 1 (PLK1) is a key regulator and coordinator for mitotic signaling that contains two major functional units of domain (KD) polo-box (PBD). While individual structures the KD PBD are known, how they interact assemble into complex remains an open question. The structural model from KD-PBD-Map205PBM heterotrimeric crystal structure zebrafish PLK1 represents step in understanding interactions. However, these domains when connected by linker full length needs further...
Intrinsically disordered proteins (IDPs) are emerging therapeutic targets for human diseases. However, probing their transient conformations remains challenging because of conformational heterogeneity. To address this problem, we developed a biosensor using point-functionalized silicon nanowire (SiNW) that allows real-time sampling single-molecule dynamics. A single IDP, N-terminal transactivation domain tumor suppressor protein p53 (p53