A5093285069- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Heat shock proteins research
- Drug Transport and Resistance Mechanisms
- Adenosine and Purinergic Signaling
- Toxin Mechanisms and Immunotoxins
- Cancer-related gene regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Amino Acid Enzymes and Metabolism
National Cancer Institute
2025
National Institutes of Health
2023-2024
National Cancer Institute
2023-2024
Center for Cancer Research
2023-2024
Hsp70, Hsp90, and ClpB/Hsp100 are molecular chaperones that help regulate proteostasis. Bacterial yeast Hsp70s their cochaperones function synergistically with Hsp90s to reactivate inactive aggregated proteins by a mechanism requires direct interaction between Hsp90 Hsp70 both in vitro vivo. Escherichia coli also collaborate bichaperone systems ClpB Hsp104, respectively, disaggregate amyloids such as prions. These collaborations dependent on interactions ClpB/Hsp104 Hsp70. We explored the...
Colorectal cancer (CRC) is the second leading cause of deaths in United States, with a five-year survival rate 65%. Oxaliplatin was first platinum drug shown to improve CRC patient outcomes and now common adjuvant therapy for advanced disease, yet 90% patients develop resistance. developed as third-generation derivative cisplatin, but recent evidence points divergent modes action. Here, genome-wide CRISPR activation knockout screens were conducted identify genetic changes that confer...
ABSTRACT Although few resistance mechanisms for histone deacetylase inhibitors (HDACis) have been described, we recently demonstrated that TMT1A (formerly METTL7A) and TMT1B METTL7B) can mediate to HDACis with a thiol as the zinc-binding group by methylating inactivating drug. are poorly characterized, their normal physiological role has yet be determined. As animal model systems often used determine function of proteins, investigated whether ability these methyltransferases methylate...