A5022779808- Blood Coagulation and Thrombosis Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cell Adhesion Molecules Research
- Phagocytosis and Immune Regulation
- Lipid metabolism and disorders
- Angiogenesis and VEGF in Cancer
- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Drug Transport and Resistance Mechanisms
- DNA Repair Mechanisms
- Amino Acid Enzymes and Metabolism
- Ovarian function and disorders
- Microbial Inactivation Methods
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Complement system in diseases
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Bacillus and Francisella bacterial research
- PARP inhibition in cancer therapy
- Acute Myeloid Leukemia Research
- Wnt/β-catenin signaling in development and cancer
- Toxin Mechanisms and Immunotoxins
- Epigenetics and DNA Methylation
- Protease and Inhibitor Mechanisms
University of Maryland, Baltimore
2016-2023
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2018-2023
Colorectal cancer (CRC) is the second leading cause of deaths in United States, with a five-year survival rate 65%. Oxaliplatin was first platinum drug shown to improve CRC patient outcomes and now common adjuvant therapy for advanced disease, yet 90% patients develop resistance. developed as third-generation derivative cisplatin, but recent evidence points divergent modes action. Here, genome-wide CRISPR activation knockout screens were conducted identify genetic changes that confer...
The transmembrane serine protease matriptase is a key regulator of both barrier-disruptive and protective epithelial cell-cell interactions. Elevated consistent feature ovarian cancers (OvCa), where multicellular spheroids shed from the primary tumor into peritoneal cavity are critical drivers metastasis. Dynamic cell-to-cell adhesive contacts required for spheroid formation maintenance. Here, we show that overactive matriptase, reflected in an increased ratio to its inhibitor hepatocyte...
Hemostasis is a delicate balance between coagulation and fibrinolysis that regulates the formation removal of fibrin, respectively. Positive negative feedback loops crosstalk fibrinolytic serine proteases maintain hemostatic to prevent both excessive bleeding thrombosis. Here, we identify novel role for glycosylphosphatidylinositol (GPI)-anchored protease testisin in regulation pericellular hemostasis. Using vitro cell-based fibrin generation assays, found expression catalytically active on...
Treatments for advanced and recurrent ovarian cancer remain a challenge due to lack of potent, selective, effective therapeutics. Here, we developed the basis transformative anticancer strategy based on anthrax toxin that has been engineered be selectively activated by catalytic power zymogen-activating proteases surface malignant tumor cells induce cell death. Exposure is cytotoxic lines spheroids derived from patient ascites. Preclinical studies demonstrate treatment induces regression in...
Ovarian cancer is one of the most fatal gynecological malignancies due to its delayed clinical presentation, indicating a need investigate molecular mechanisms advanced disease. Dysregulated proteolysis contributes crucial steps ovarian metastasis, including shedding and dissemination cells peritoneal cavity. Several studies have identified membrane‐anchored serine proteases, namely testisin matriptase, that are aberrantly overexpressed in cancer. However, detailed activation, regulation,...