A5086506690- vaccines and immunoinformatics approaches
- Bioinformatics and Genomic Networks
- Machine Learning in Bioinformatics
- Water Quality and Pollution Assessment
- SARS-CoV-2 and COVID-19 Research
- Water Quality and Resources Studies
- Genetics, Bioinformatics, and Biomedical Research
- Fish Ecology and Management Studies
- SARS-CoV-2 detection and testing
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
Hope College
2020-2022
Understanding the molecular evolution of SARS-CoV-2 virus as it continues to spread in communities around globe is important for mitigation and future pandemic preparedness. Three-dimensional structures proteins those other coronavirusess archived Protein Data Bank were used analyze viral proteome during first 6 months COVID-19 pandemic. Analyses spatial locations, chemical properties, structural energetic impacts observed amino acid changes >48 000 isolates revealed how each one 29 have...
Abstract Three-dimensional structures of SARS-CoV-2 and other coronaviral proteins archived in the Protein Data Bank were used to analyze viral proteome evolution during first six months COVID-19 pandemic. Analyses spatial locations, chemical properties, structural energetic impacts observed amino acid changes >48,000 sequences showed how each one 29 study have undergone changes. Structural models computed for every unique sequence variant revealed that most substitutions map protein...
The Biochemistry Authentic Scientific Inquiry Laboratory (BASIL) has provided undergraduate biochemistry students with an inquiry-based investigation into protein structure using a combination of computational and wet-lab experimentation. Based on the skill set developed, BASIL faculty were invited to join week-long online boot camp hosted by Dr. Stephen Burley colleagues at Rutgers University Institute for Quantitative Biomedicine in July 2020. This session, entitled "The Summer...