A5021479702- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Mechanical Circulatory Support Devices
- Microbial metabolism and enzyme function
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Metal-Catalyzed Oxygenation Mechanisms
- vaccines and immunoinformatics approaches
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Trauma Management and Diagnosis
- Anesthesia and Neurotoxicity Research
- Hemodynamic Monitoring and Therapy
- Porphyrin Metabolism and Disorders
- Genetics, Bioinformatics, and Biomedical Research
- Infective Endocarditis Diagnosis and Management
- Pericarditis and Cardiac Tamponade
- Pleural and Pulmonary Diseases
- Atrial Fibrillation Management and Outcomes
- Computational Drug Discovery Methods
- Light effects on plants
- Cardiac tumors and thrombi
Xavier University
2018-2025
University of San Diego
2010-2012
University of California, San Francisco
2011-2012
Neurological Surgery
2012
Lawrence Berkeley National Laboratory
2005
University of California, Berkeley
1999-2002
Wake Forest University
1985-1995
Atrium Health Wake Forest Baptist
1984-1995
High Point University
1995
University Medical Center
1985-1994
ADVERTISEMENT RETURN TO ISSUECurrent Topics/Persp...Current Topics/PerspectivesNEXTCatalytic Mechanism of the Topa Quinone Containing Copper Amine Oxidases†Minae Mure, Stephen A. Mills, and Judith P. KlinmanView Author Information Department Chemistry, University California, Berkeley, California 94720 Cite this: Biochemistry 2002, 41, 30, 9269–9278Publication Date (Web):June 25, 2002Publication History Received27 March 2002Revised23 May 2002Published online25 June inissue 1 July...
Changes in cerebral blood flow (CBF) response to changes PaCO2 were measured by intraaortic injection of 133Xe 12 patients during hypothermic (23-30 degrees C) cardiopulmonary bypass. In each patient, CBF was determined at two randomly ordered levels obtained varying the rate gas inflow into pump oxygenator (Group I, n = 6) or percentage CO2 added II, 6). Nasopharyngeal temperature, mean arterial pressure, pump-oxygenator flow, and hematocrit maintained within a narrow range. group...
Understanding the molecular evolution of SARS-CoV-2 virus as it continues to spread in communities around globe is important for mitigation and future pandemic preparedness. Three-dimensional structures proteins those other coronavirusess archived Protein Data Bank were used analyze viral proteome during first 6 months COVID-19 pandemic. Analyses spatial locations, chemical properties, structural energetic impacts observed amino acid changes >48 000 isolates revealed how each one 29 have...
The ferric uptake regulator is a metal-dependent transcription repressor that activated by divalent transition metal cations. Fe(II) believed to be the primary functional in vivo; however, ability of other cations activate Fur brings into question true physiological metal. Furthermore, role different oxidation states iron activating has not been determined. Comparison affinity metals with intracellular concentrations would suggest which no accurate determinations for have reported. In this...
To test whether the radial artery-to-aorta pressure gradient seen in some patients after cardiopulmonary bypass (CPB) is due to reduction hand vascular resistance, authors compared pressures ascending aorta with artery before and CPB 12 patients. They increased resistance by briefly occluding ulnar arteries at wrist recorded that effect on relationship. also of compression 38 not having aortic measurements. Before first patients, systolic arterial (SAP) was significantly higher (P less than...
Supratentorial hemangioblastoma is a rare form of hemangioblastoma; little information available regarding prognosis, treatment, and clinical characteristics, because the literature primarily composed case reports small series.Therefore, we performed systematic review to analyze disease progression, surgical outcomes with respect survival for supratentorial hemangioblastomas.The rate progression-free (PFS) was determined using Kaplan-Meier analysis.Differences in categorical factors,...
The role of metal in copper amine oxidases was studied by removal and replacement the enzyme from Hansenula polymorpha. active-site cupric ion reduced with substrate, methylamine, removed anaerobic dialysis against cyanide EDTA. Metal-free protein found to have little or no activity oxidizing methylamine unreactive toward phenylhydrazine. Addition cobaltous metal-free restored 19% native specific 75% reactivity A detailed kinetic study cobalt-substituted oxidase revealed that major cause a...
Abstract Three-dimensional structures of SARS-CoV-2 and other coronaviral proteins archived in the Protein Data Bank were used to analyze viral proteome evolution during first six months COVID-19 pandemic. Analyses spatial locations, chemical properties, structural energetic impacts observed amino acid changes >48,000 sequences showed how each one 29 study have undergone changes. Structural models computed for every unique sequence variant revealed that most substitutions map protein...
Abstract Cryptochromes are blue light‐absorbing photoreceptors found in plants and animals with many important signalling functions. These include control of plant growth, development, the entrainment circadian clock. Plant cryptochromes have recently been implicated adaptations to temperature variation, including compensation However, effect directly on photochemical properties cryptochrome photoreceptor remains unknown. Here we show that response light purified Arabidopsis Cry1 Cry2...
Epinephrine and calcium possess both cardiac inotropic vasopressor activity. In addition, epinephrine's cardiovascular effects are mediated via increases in intracellular calcium. As a result, many clinicians administer the two agents together an attempt to augment their effects. Although this approach seems rational, it has never been proven effective. We evaluated hyperglycemic actions of epinephrine (10 30 ng/kg/min), with without chloride administration mg/kg bolus followed by 2 mg/kg/hr...
Infective endocarditis of bacterial or fungal origin may arise in either the left right heart and can involve both natural prosthetic valves. The diagnosis is based primarily upon clinical criteria positive blood cultures, but serial electrocardiograms, fluoroscopy, two-dimensional echocardiograms also be helpful. initial treatment should consist antibiotic therapy itself often adequate effecting cure. However, careful observation during mandatory, since development congestive failure due to...
ABSTRACT In the Biochemistry Authentic Scientific Inquiry Lab (BASIL) course-based undergraduate research experience, students use a series of computational (sequence and structure comparison, docking) wet lab (protein expression, purification, concentration; sodium dodecyl sulfate-polyacrylamide gel electrophoresis [SDS-PAGE]; enzyme activity kinetics) modules to predict test function protein structures unknown found in Protein Data Bank UniProt. BASIL was established 2015 with core 10...