A5009416445- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Melanoma and MAPK Pathways
- Biomedical Text Mining and Ontologies
- Reproductive System and Pregnancy
- Cervical Cancer and HPV Research
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Molecular Biology Techniques and Applications
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Genomics and Rare Diseases
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Cutaneous Melanoma Detection and Management
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
Sapienza University of Rome
2024
National Research Council
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
Alleanza Contro il Cancro
2023
Institute for Experimental Endocrinology and Oncology
2023
Current prognostic factors for endometrial cancer are not sufficient to predict recurrence in early stages. Treatment choices based on the included risk classes defined by ESMO-ESGO-ESTRO (European Society Medical Oncology-European of Gynaecological Radiotherapy and Oncology) consensus conference with new biomolecular classification POLE, TP53, microsatellite instability status. However, a minority stage cases relapse regardless their low profiles. Integration immune context status existing...
Abstract Background The current therapeutic algorithm for Advanced Stage Melanoma comprises of alternating lines Targeted and Immuno-therapy, mostly via Immune-Checkpoint blockade. While Comprehensive Genomic Profiling solid tumours has been approved as a companion diagnostic, still no predictive biomarkers are available aside from BRAF mutations the controversial Tumor Mutational Burden. This study presents results Multi-Centre Observational Clinical Trial on Target Immuno-therapy treated...
Molecular Tumor Boards (MTB) operating in real-world have generated limited consensus on good practices for accrual, actionable alteration mapping, and outcome metrics. These topics are addressed herein 124 MTB patients, all accrued at progression, lacking approved therapy options.Actionable genomic alterations identified by tumor DNA (tDNA) circulating (ctDNA) profiling were mapped customized OncoKB criteria to reflect diagnostic/therapeutic indications as Europe. Alterations considered...
The most recent international guidelines regarding recurrent pregnancy loss (RPL) exclude of the immunological tests recommended for RPL since they do not reach an evidence-based level. Comparisons metanalysis and systematic reviews are limited by ambiguity in terms definition, etiological risk factors, diagnostic work-up, treatments applied. Therefore, cohort heterogeneity, inadequacy numerosity, quality data confirm a standardized research field, especially background, which potential...
The Biomedical Research field is currently advancing to develop Clinical Trials and translational projects based on Real World Evidence. To make this transition feasible, clinical centers need work toward Data Accessibility Interoperability. This task particularly challenging when applied Genomics, that entered in routinary screening the last years via mostly amplicon-based Next-Generation Sequencing panels. Said experiments produce up hundreds of features per patient, their summarized...
<h3>Introduction/Background</h3> Endometrial cancer (EC) treatments are related to known prognostic factors included in the risk classes defined by ESMO-ESGO-ESTRO consensus conference,together with biomolecular classification. However,these not sufficient predict recurrence rate at early stages. The integration of immune signatures existing molecular based models has been extensively evaluated,nor mentioned guidelines. aim this study is improve clinical prediction integrating guidelines new...
Bioinformatics and Data Science are routinely challenged to take out intelligible results from huge amounts of data. These results, in turn, conveyed through plots visualizations that should be easily reproducible for scientific soundness ethical reasons. This process is critical importance Genomics, when dealing with large multi-omics datasets. One the final steps these analyses Gene Set enrichment, where web tools represent a valuable resource but not reliable surrogate standardized,...