A5113023360- Hepatitis B Virus Studies
- Hepatitis C virus research
- RNA Interference and Gene Delivery
- Signaling Pathways in Disease
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Bacteriophages and microbial interactions
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
- RNA Research and Splicing
Shandong University
2023-2025
T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is an immune checkpoint that has critical roles in exhaustion. However, little known about the mechanisms regulate TIM-3 surface expression turnover. Here, we report human palmitoylated by palmitoyltransferase DHHC9 at residue cysteine 296 (Cys
Hepatitis B virus (HBV) capsid assembly modulators (CAMs) represent a promising therapeutic approach for the treatment of HBV infection. In this study, we designed and synthesized five series benzamide derivatives based on multisite-binding strategy at tolerant region diversity modification in solvent-exposed region. Among them, thioureidobenzamide compound 17i exhibited significantly increased anti-HBV activity HepAD38 (EC50 = 0.012 μM) HBV-infected HLCZ01 cells 0.033 μM). Moreover,...
Abstract Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) contributes to viral persistence and recurrence, however, how the host innate immune system responds cccDNA is still less known. Here, based on cccDNA‐hepatic proteins interaction profiling, sensor ATP‐binding cassette subfamily F member 1 (ABCF1) identified as a novel cccDNA‐binding protein restriction factor for HBV replication. Mechanistically, ABCF1 recognizes by KKx4 motif forms phase‐separated condensates...
Objectives: Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) contributes to viral persistence and recurrence. However, it is still less known how the host immune system responds cccDNA suppresses HBV replication. Therefore, essential explore proteins that interact with efficiently suppress Design: The interaction of ABCF1 was assessed by ChIP pull-down assay. replication in different cell models, including surrogate-transfected HBV-infected hepatocytes models. Phase separation...