A5101490006- PARP inhibition in cancer therapy
- Circular RNAs in diseases
- Genetics and Neurodevelopmental Disorders
- Genomics and Chromatin Dynamics
- Parkinson's Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- RNA Research and Splicing
- MicroRNA in disease regulation
Albert Einstein College of Medicine
2024
University of Lübeck
2019-2021
Abstract Understanding how chromatin organisation is duplicated on the two daughter strands a central question in epigenetics. In mammals, following passage of replisome, nucleosomes lose their defined positioning and transcription contributes to re-organisation. However, whether plays greater role organization DNA replication remains unclear. Here we analysed protein re-association with newly replicated upon inhibition using iPOND coupled quantitative mass spectrometry. We show that...
Circular RNA is progressively reported to occur in various species including mammals where it thought be involved the post-transcriptional regulation of gene expression, partly via interactions with microRNA. Here, we asked whether circular topology causes functional differences linear forms when interacting short strands vitro and human cells. Kinetic studies bladder cancer-derived synthetic versus transcripts, respectively, oligoribonucleotides showed similar association rates for both...