A5090813544- Sarcoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Family Support in Illness
- Chemotherapy-induced cardiotoxicity and mitigation
- Lung Cancer Treatments and Mutations
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Neuroblastoma Research and Treatments
- Colorectal Cancer Treatments and Studies
- Palliative Care and End-of-Life Issues
- Thyroid Cancer Diagnosis and Treatment
- Adolescent and Pediatric Healthcare
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Cancer survivorship and care
- Neurofibromatosis and Schwannoma Cases
- Glioma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Drug Transport and Resistance Mechanisms
- Chronic Lymphocytic Leukemia Research
- Cancer Risks and Factors
- Nutrition and Health in Aging
- Management of metastatic bone disease
- Acute Myeloid Leukemia Research
Eli Lilly (United States)
2018-2025
Fred Hutch Cancer Center
2024
Loxo Oncology at Lilly (United States)
2024
Methodist Dallas Medical Center
2023
American Congress of Obstetricians and Gynecologists
2023
Weston Park Cancer Centre
2023
Huntsman Cancer Institute
2010-2022
Seagen (United States)
2022
University of Utah
2010-2021
University of Nottingham
2021
Exosomes found in the circulation are a primary source of important cancer-related RNA and protein biomarkers that expected to lead early detection, liquid biopsy, point-of-care diagnostic applications. Unfortunately, due their small size (50–150 nm) low density, exosomes extremely difficult isolate from plasma. Current isolation methods time-consuming multistep procedures unlikely translate into To address this issue, we demonstrate ability an alternating current electrokinetic (ACE)...
Wild-type (WT) gastrointestinal stromal tumors (GISTs), which lack KIT and PDGFRA gene mutations, are the primary form of GIST in children occasionally occur adults. They respond poorly to standard targeted therapy. Better molecular clinical characterization could improve management.To evaluate tumor genomic features WT GIST.Patients enrolled an observational study at National Institutes Health starting 2008 were evaluated a clinic held once or twice yearly. Patients provided access existing...
Patients with advanced soft tissue sarcoma (STS) have a median overall survival of less than 2 years. In phase study, an benefit in this population was observed the addition olaratumab to doxorubicin over alone.To determine efficacy plus patients advanced/metastatic STS.ANNOUNCE confirmatory, 3, double-blind, randomized trial conducted at 110 sites 25 countries from September 2015 December 2018; final date follow-up 5, 2018. Eligible were anthracycline-naive adults unresectable locally or...
Selpercatinib, a highly selective, potent RET inhibitor, has shown efficacy in advanced RET-mutant medullary thyroid cancer phase 1–2 trial, but its as compared with approved multikinase inhibitors is unclear. Download PDF of the Research Summary. We conducted 3, randomized trial comparing selpercatinib first-line therapy physician's choice cabozantinib or vandetanib (control group). Eligible patients had progressive disease documented within 14 months before enrollment. The primary end...
Abstract BACKGROUND: Health care outcomes for long‐term survivors of adolescent and young adult (AYA) cancer were compared with adults without a history, using the 2009 Behavioral Risk Factor Surveillance System data. METHODS: Eligible participants 20 to 39 years age. There N = 979 who self‐reported diagnosis between ages 15 34 at least 5 from (excluding nonmelanoma skin cancer). The remaining 67,216 no history used as controls. Using multivariable regressions, relative risks 95% confidence...
Regorafenib is one of several FDA-approved cancer therapies targeting multiple tyrosine kinases. However, there are few subtype-specific data regarding kinase inhibitor activity in sarcomas. We report results a single arm, phase II trial regorafenib advanced Ewing family sarcomas.Patients with metastatic sarcomas (age ≥ 18, ECOG 0-2, good organ function) who had received at least line therapy and experienced progression within 6 months registration were eligible. Prior inhibitors not...
Purpose Wild-type gastrointestinal stromal tumors (WT-GISTs) that lack KIT or PDGFRA mutations represent a unique subtype of GIST predominantly affects children. We sought to determine the effect on event-free survival (EFS) staging variables, extent resection, and repeat resection tumors. Methods In 2008, WT-GIST clinic was established at National Cancer Institute, allowing development large clinical database. included participants who underwent WT-GIST. Associations with EFS (ie, freedom...
This study uses qualitative methods to identify barriers and facilitators of exercise healthy eating among adolescent young adult (AYA) cancer survivors (survivors currently aged 18-39 years diagnosed with anytime in their lives), as reported by primary supporters.
LBA3 Background: Dox is standard therapy in STS. In a Ph 2 trial, olaratumab (a human IgG1 antibody targeting PDGFRα) + dox improved overall survival (OS) and progression-free (PFS) vs dox. ANNOUNCE aimed to confirm the OS benefit advanced Methods: Adult pts with unresectable locally or metastatic STS, anthracycline-naïve, ECOG PS 0-1 were eligible. Pts randomized 1:1 (20mg/kg Cycle 1, 15mg/kg subsequent cycles) PBO on Days 1 8 of each 21-day cycle combined (75mg/m ) Day for up cycles. After...
Abstract Objective To evaluate the utility of a method for estimating glomerular filtration rate (GFR) after single IV administration iohexol. Design The plasma clearance iodine (PCI), taken as quotient administered dose (300 to 600 mg l/kg body weight) divided by area under concentration versus time curve determined 4 methods (PCI 1 –PCI ). results PCI were compared with simultaneously obtained values urinary exogenously creatinine (CCr), widely accepted measurement GFR in cats and dogs....
The Dachshund (dac) gene, initially cloned as a dominant inhibitor of the Drosophila hyperactive EGFR mutant ellipse, encodes key component cell fate determination pathway involved in eye development. Analysis more than 2,200 breast cancer samples showed improved survival by some 40 months patients whose tumors expressed DACH1. Herein, DACH1 and estrogen receptor-alpha (ERalpha) expressions were inversely correlated human cancer. bound inhibited ERalpha function. Nuclear expression estradiol...
Childhood cancer survivors may be at increased risk of hospitalization because cancer-related late effects.
Abstract Purpose: Few prospective studies have assessed anthracycline-associated cardiotoxicity in patients with sarcoma. We evaluated soft-tissue sarcomas administered doxorubicin the phase III ANNOUNCE trial (NCT02451943). Patients and Methods: were anthracycline-naïve adults locally advanced or metastatic disease left ventricular ejection fraction (LVEF) ≥50%. could receive eight cycles of at 75 mg/m2. The cardioprotectant, dexrazoxane, was allowed investigator discretion. Symptomatic...
Abstract Context Activating RET alterations have been reported in a variety of solid tumors, including pheochromocytoma where they occur both sporadically and as part familial multiple endocrine neoplasia type 2 (MEN2) syndromes. Selpercatinib is first-in-class, highly selective, potent small molecule kinase inhibitor that has demonstrated marked durable antitumor activity diverse RET-activated tumors the LIBRETTO-001 study (NCT03157128). Methods We describe first 6 cases treated with...
// Zuoren Yu 1,2 , Zengguang Xu 1 Gabriele DiSante 2 Jennifer Wright Min Wang Yuan Li Qian Zhao Tao Ren Xiaoming Ju Ellen Gutman Guangxue Sankar Addya Tieyan Zhendong Xiang 3 Chenguang Xiongfei yang Xiaolai Yang Richard Pestell Research Center for Translational Medicine, Key Laboratory of Arrhythmias the Ministry Education, East Hospital, Tongji University School Shanghai, China, Departments Cancer Biology, Kimmel Center, Thomas Jefferson University, Philadelphia PA People's Hospital Gansu...
11005 Background: Pazopanib is approved for soft tissue sarcoma pts after failure of other therapy, but there are few subtype-specific data regarding kinase inhibitor activity. We report on a single arm, phase II trial REGO in advanced EWS. Methods: EWS (age > 18, ECOG 0-2, good organ function) who had at least 1 line therapy and PD within 6 mo were eligible. Prior oral inhibitors not allowed. Initial dose was 160 mg PO QD x21 q28d. Dose reductions employed toxicity AEs. The primary...
TPS845 Background: KRAS G12D mutations occur in ~35%, 13%, and 4% of pancreatic, colorectal, non-small cell lung cancers, respectively less commonly other cancers. Currently, there are no approved therapies for patients with -mutant solid tumors. LY3962673 is a potent orally bioavailable inhibitor GDP-bound that highly selective against wild-type RAS or amplifications. Preclinically, demonstrated robust anti-tumor activity vivo as single-agent combination agents multiple PDX models (Gong X,...
Background There are several options for proximal humerus reconstruction in young children after resection of a malignant tumor and no one technique has been definitively shown to be superior others, leaving the decision surgeon patient choice. Claviculo pro humeri (CPH) is biologic using patient's ipsilateral clavicle as rotational osseous flap. CPH represents potential option this complicated clinical problem very children, but little known about it because indications its use so uncommon....
Purpose: Survivors of cancer diagnosed during adolescence and young adulthood (AYA; aged 15-39) may experience quality life (QOL) limitations; however, little is known about QOL for AYA survivors who are now middle-aged or among racial/ethnic minority survivors. We evaluated outcomes relative to a non-cancer comparison group by gender, race/ethnicity, current age. Methods: Using the 2009 Behavioral Risk Factor Surveillance System (BRFSS) data, we identified 8375 individuals with while 15-39...
To explore adolescent and young adult (AYA) cancer survivors' internet use in seeking healthy lifestyle behavior (HLB) information on diet exercise.Twenty-five AYA survivors participated focus groups or interviews. Data were analyzed using qualitative content analysis.Most (92%) sought HLB from sources. Key issues included the following: (1) too much available, (2) not meeting unique needs, (3) concerns about trustworthiness of information.Although to seek information, resources could be...