A5014064794- Analytical Methods in Pharmaceuticals
- Neuroscience and Neuropharmacology Research
- Pharmacology and Obesity Treatment
- 3D Printing in Biomedical Research
- Antibiotics Pharmacokinetics and Efficacy
- Chemical synthesis and alkaloids
- Cholinesterase and Neurodegenerative Diseases
- Analytical Chemistry and Chromatography
- Radiation Therapy and Dosimetry
- Anesthesia and Sedative Agents
- Pharmacological Effects and Toxicity Studies
- Prenatal Substance Exposure Effects
- Pregnancy and preeclampsia studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmacogenetics and Drug Metabolism
- Spaceflight effects on biology
- Enzyme function and inhibition
- Neuropeptides and Animal Physiology
Hebrew University of Jerusalem
2021-2024
The aim of this study was to investigate the comparative antiseizure activity
Abstract Objective We have previously shown that valproic acid (VPA) alters the expression of placental carriers essential nutrients, including folates. Here, we exposed a cell line to VPA, its central nervous system‐active amide derivative sec ‐butylpropylacetamide (SPD), and individual stereoisomers address question whether folate carrier can predict teratogenicity VPA‐related compounds. additionally conducted pilot analysis transfer across monolayers estimate translation altered activity....
To investigate the comparative antiseizure activity of individual enantiomers fenfluramine and its major active primary metabolite norfenfluramine in rodent seizure models, relationship with pharmacokinetics these compounds plasma brain.The potency d,l-fenfluramine (racemic fenfluramine) was compared respective potencies using maximal electroshock (MES) test rats mice, 6-Hz 44 mA mice. Minimal motor impairment assessed simultaneously. The time course protection concentration profiles...
In the absence of safety data in humans, use cannabidiol (CBD) is not recommended during pregnancy. Yet >50% pregnancies women with epilepsy are unintended, making fetal exposure to CBD possible. As a small-molecule, highly lipid-soluble drug, likely be distributed into placenta and cross it. To estimate placental distribution profile its potential short-term effects, we conducted an ex vivo perfusion study human placentas.Placentas were obtained from healthy undergoing cesarean deliveries....
Abstract The effect of fenfluramine and norfenfluramine enantiomers in rodent seizure models their correlation with the pharmacokinetics d ‐ l ‐fenfluramine rats have been reported recently. To complement these findings, we investigated rat plasma brain. Sprague‐Dawley were injected intraperitoneally 20 mg/kg 1 norfenfluramine. A dose ‐norfenfluramine was used because higher doses caused severe toxicity. concentration each enantiomer brain determined at different time points by liquid...
We recently reported a new class of carbamate derivatives as anticonvulsants. Among these, 3-methylpentyl(4-sulfamoylphenyl)carbamate (MSPC) stood out the most potent compound with ED50 values 13 mg/kg (i.p.) and 28 (p.o.) in rat maximal electroshock test (MES). 3-Methylpropyl(4-sulfamoylphenyl)carbamate (MBPC), characterized here, is an MSPC analogous two less aliphatic carbon atoms its structure. As both MBPC are chiral compounds, we studied carbonic anhydrase inhibitory anticonvulsant...
Objectives: To investigate the comparative antiseizure activity of l-enantiomers d,l-fenfluramine and d,l-norfenfluramine to evaluate relationship between their concentration in plasma brain anticonvulsant activity.
 Methods: d,l-Fenfluramine, individual enantiomers were evaluated mouse maximal electroshock seizure (MES) test. also assessed DBA/2 audiogenic model. All compounds administered intraperitoneally. Brain concentrations test mice quantified correlated with Results: In MES...
The space environment can affect the function of all physiological systems, including properties cell membranes. Our goal in this study was to explore effect simulated microgravity (SMG) on cellular uptake small molecules based reported microgravity-induced changes membrane properties. SMG applied cultured cells using a random-positioning machine for up three hours. We assessed accumulation compounds representing substrates and efflux transporters, not shown be transported by carriers....