A5087992652- Ear Surgery and Otitis Media
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Tracheal and airway disorders
- Otolaryngology and Infectious Diseases
- Vestibular and auditory disorders
- Airway Management and Intubation Techniques
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Facial Nerve Paralysis Treatment and Research
- Pharmacological Effects and Toxicity Studies
- Drug-Induced Hepatotoxicity and Protection
- Noise Effects and Management
- Obstructive Sleep Apnea Research
- Whipple's Disease and Interleukins
- Ultrasonics and Acoustic Wave Propagation
- Cleft Lip and Palate Research
- Voice and Speech Disorders
- Cerebral Venous Sinus Thrombosis
- Head and Neck Anomalies
- Speech and Audio Processing
- Ear and Head Tumors
- Vitamin K Research Studies
- Enzyme function and inhibition
- Phenothiazines and Benzothiazines Synthesis and Activities
Shaare Zedek Medical Center
2013-2025
Hebrew University of Jerusalem
2014-2025
The Royal Victorian Eye & Ear Hospital
2018-2023
Hadassah Medical Center
2016-2022
The University of Melbourne
2018-2021
Hadassah Academic College
2016
Abstract Objective To identify the intracochlear electrode position in cochlear implant recipients and determine correlation to speech perception for two peri-modiolar arrays. Methods Post-operative cone-beam computed tomography images of 92 adult ‘CI512’ 18 ‘CI532’ were analysed. Phonemes scores recorded pre-implantation, at 3 12 months post-implantation. Results All CI532 electrodes wholly within scala tympani. Of 79 CI512 intended be tympani, 58 (73 per cent) 14 (17 translocated 7 (9...
Objectives: Real-time electrocochleography (ECochG) has been used as a monitoring tool during cochlear implantation (CI), whereby, amplitude drops have correlated with postoperative acoustic hearing results. However, no consensus reached to how single event of an drop should be characterized. The aim this study was identify ECochG events that predict loss 1 month after surgery. Design: Fifty-five patients were included in prospective cohort study. measurements performed CI electrode...
Spikes in cochlear implant impedance are associated with inner ear pathology after implantation. Here, we correlate these spikes episodes of hearing loss and/or vertigo, a comparison between lateral wall and peri-modiolar electrode arrays.Seven hundred seventy recipients Cochlear's slim-straight, (CI422), or (CI512) were investigated for spikes. Impedance fluctuations defined as median rise ≥ 4 kΩ across all intracochlear electrodes from baseline measurements taken 2 weeks switch-on. Medical...
Objective: To describe the tip fold over rate, scalar localization, and speech perception outcomes of CI532 Slim Modiolar Electrode. Patients Intervention: All patients receiving implant before June 2018. Main Outcome Measures: measures for adults include pre- postoperative perception, operative report details, electrode position as determined by X-ray cone beam computed tomography. Comparison made with previous experience Contour perimodiolar (CI512). In pediatric population fold-over...
Real-time electrocochleography (rt-ECochG) is a method to detect intracochlear potential changes during cochlear implantation (CI). Steep amplitude drops of the microphonic (CM) signal (so called "ECochG events") have been correlated with worse residual hearing outcomes. However, sensitivity and specificity monitoring CM on its own are too low use it as biomarker. The aim this article was establish if additional components would help better predict postoperative outcomes.Single-center,...
Abstract Cochlear implantation has successfully restored the perception of hearing for nearly 200 thousand profoundly deaf adults and children. More recently, implant candidature expanded to include those with considerable natural which, when preserved, provides an improved experience in noisy environments. But more than half these patients lose this soon after implantation. To reduce burden, biosensing technologies are emerging that provide feedback on quality surgery. Here we report...
BACKGROUND The thyroid cartilage is the most prominent laryngeal located beneath hyoid bone. Non-traumatic fractures of larynx, including cartilage, are rare and can occur when glottis closed intrathoracic pressure suddenly increases. This report describes case a 42-year-old man presenting with hoarseness pain swallowing diagnosis non-traumatic fracture following sudden neck movement, highlighting importance recognizing atypical mechanisms injury. CASE REPORT A healthy experienced "pop" in...
To present a systematic approach for evaluating the fetal pharynx and larynx based on two- three-dimensional ultrasound (2D-US 3D-US) modalities, describing sonographic appearance function of upper respiratory tract measuring anatomical components larynx.Gravidae presenting from late first trimester to mid-gestation routine booked examinations with structurally normal singleton fetuses confirmed gestational age were enrolled. Transabdominal 2D-US was performed functional evaluation larynx....
Objective: The aim was to study the therapeutic management, recurrence, and need for tonsillectomy in patients who underwent needle aspiration peritonsillar abscess (PTA). Methods: A prospective observational design performed. Patients hospitalized Shaare Zedek Medical Center between years 2004 2007 with a diagnosis of PTA obtaining pus were included. minimum 5-year follow-up required all patients. Recurrences, complications, repeated surgical procedure, length hospital admission, primary...
The widely accepted treatment for sudden sensorineural hearing loss (SSNHL) is corticosteroid (oral or intratympanic). main goal of this work to define the significance time between symptom onset and initiation, as well other prognostic factors, improvement.This retrospective study included 666 patients treated SSNHL. Demographic data, audiometry, method, since onset, associated symptoms were recorded each patient. divided into five groups according initiation time-half a week, one 2 weeks,...
<h3>BACKGROUND:</h3> Tracheostomy in patients who are critically ill is generally performed due to prolonged mechanical ventilation and expected extubation failure. However, tracheostomy criteria ideal timing poorly defined, including equivocal data from randomized controlled trials median intubation times that range 7–21 d. a consistent finding only ∼50% of late groups actually undergo tracheostomy, with non-performance recovery or clinical deterioration. Unlike many jurisdictions, elective...
Objectives To translate and validate the Zurich Chronic Middle Ear Inventory (ZCMEI‐21) for English language in order to provide an instrument assess health‐related quality of life chronic otitis media (COM). Design Pilot translation study including cognitive debriefings, prospective multicentre cross‐sectional psychometric validation study. Setting Four tertiary referral centres three different English‐speaking countries (UK, USA Australia). Participants Adult patients suffering from COM....
Cytochrome P450 2C9 (CYP2C9) is responsible for the oxidative metabolism of about 15% commonly used drugs, some which are characterized by a narrow therapeutic window. CYP2C9 highly polymorphic, and over 60 alleles have been described. CYP2C9*2 CYP2C9*3 most common polymorphisms among White patients both associated with decreased activity. The evidence concerning functional importance less frequent variant scarce. objective current study was to characterize in vivo activity carriers...
To investigate the comparative antiseizure activity of individual enantiomers fenfluramine and its major active primary metabolite norfenfluramine in rodent seizure models, relationship with pharmacokinetics these compounds plasma brain.The potency d,l-fenfluramine (racemic fenfluramine) was compared respective potencies using maximal electroshock (MES) test rats mice, 6-Hz 44 mA mice. Minimal motor impairment assessed simultaneously. The time course protection concentration profiles...
Infectious complications occurring in cochlear implant (CI) recipients is of potentially major impact. A better understanding severe infections this cohort necessary.Single-center, retrospective study. Level Evidence 2B.Single-center, study at a tertiary referral hospital.We included all patients who received CI our institution between 1983 and end 2018 (4,622 implantations).Prevalence, incidence, risk factors, functional outcomes infections.There was an overall prevalence 0.65% infections....
To assess the safety and efficacy of multiple sessions electrostimulation by a transtympanic needle electrode on promontory for tinnitus relief.Prospective open, unblinded, uncontrolled clinical trial.Tertiary academic referral center.Ten patients (8 male 2 female subjects), mean age 50.1 ± 12 years (range, 34-67) with severe unilateral completed all stages study. Patients duration between 6 months to 3 were included.The underwent consecutive 30-minute sessions, every other day, biphasic,...