A5031744903- Gastrointestinal disorders and treatments
- Psoriasis: Treatment and Pathogenesis
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Inflammatory Bowel Disease
- Cytokine Signaling Pathways and Interactions
- Hair Growth and Disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Cytomegalovirus and herpesvirus research
- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Prosthetics and Rehabilitation Robotics
- Immune cells in cancer
- Medicinal Plant Pharmacodynamics Research
- Wireless Sensor Networks and IoT
- Ideological and Political Education
- Autoimmune and Inflammatory Disorders
- Atherosclerosis and Cardiovascular Diseases
- Calcium signaling and nucleotide metabolism
- Potassium and Related Disorders
- High Temperature Alloys and Creep
Yuxian People's Hospital
2025
First Affiliated Hospital Zhejiang University
2019-2025
Nanjing Drum Tower Hospital
2025
Nanjing University
2022-2024
Zhejiang University
2018-2023
Tongji University
2023
Shanghai Jiao Tong University
2023
Shanghai Tenth People's Hospital
2023
China Pharmaceutical University
2023
Pingdingshan University
2022
Inflammatory bowel disease (IBD) has become a major health challenge worldwide. However, the precise etiological and pathophysiological factors involved in IBD remain unclear. Proteomics can be used for large-scale protein identification analysis. In current study, using tandem mass tag- (TMT-) based shotgun proteomics, proteomic differences between intestinal tissue from controls, patients with Crohn’s (CD), ulcerative colitis (UC) were compared. Proteins fold change >2 or <0.5 P...
Psoriasis is an incurable chronic inflammatory disease that requires new interventions. Here, we found fibroblasts exacerbate psoriasis progression by promoting macrophage recruitment via CCL2 secretion single-cell multi-omics analysis. The natural small molecule celastrol was screened to interfere with the of and improve psoriasis-like symptoms in both murine cynomolgus monkey models. Mechanistically, directly bound low-density lipoprotein receptor-related protein 1 (LRP1) β-chain abolished...
A 16-year-old girl, a high school student, presented with 2-year history of intermittent pain in the left upper abdomen. Routine laboratory tests performed at time admission were normal. Contrast-enhanced abdominal computed tomography revealed an intussusception-like appearance duodenojejunal junction ([Fig. 1]).
OBJECTIVES: The diagnostic value of different noninvasive modalities and the endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) reliability duodenal gastrointestinal stromal tumors (GISTs) are ambiguous in present studies. METHODS: Patients with a histopathological diagnosis primary GISTs between years 2008 2018 were analyzed. Data on treatment clinicopathological features recorded. Furthermore, computed tomography (CT)/magnetic resonance imaging (MRI), EUS, EUS-FNA results...
The exoskeleton is often regarded as a tool for rehabilitation and assistance of human movement. control schemes were conventionally implemented by developing accurate physical kinematic models, which lack robustness to external variational disturbing forces. This paper presents virtual neuromuscular robotic ankle standing balance. the proposed method was improved applying specific model estimate desired torques balance control. In specialty, has two key components, including musculoskeletal...
Abstract Background Psoriasis is a chronic inflammatory genetic disease, mainly manifesting in the skin. Conventional therapies, such as glucocorticosteroids and corticosteroids, have adverse effects that limit drug use. Hence, it imperative to identify new therapeutic strategy exhibits favorable safety profile. Shi-Bi-Man (SBM) safe herbal supplement sourced from various natural plants, including ginseng, angelica sinensis, polygonum multiflorum, aloe vera. Purpose We aimed find potential...
The differential diagnosis of Crohn disease (CD) from intestinal tuberculosis (ITB) and primary lymphoma (PIL) is challenging in patients who exhibit atypical clinical characteristics. aim the present study was to explore serum proteome profiles CD, PIL ITB identify their differentiations.Treatment-naïve with CD (n = 10), 10) were enrolled study. Differentially expressed proteins (DEPs) patient samples compared between groups using tandem mass tag labeled proteomic technology. A principal...
The aim of this study was to investigate the expression features discordant inflammatory bowel disease (IBD) twin pairs identify novel molecular and markers. We collected an dataset with ulcerative colitis performed integrative analysis genetic-independent features. Through deconvolution immune cell populations tissue specificity, we refined candidate genes for susceptibility colitis. found that dysregulated systems NOD-related pathways were enriched in network IBD pairs. Among identified...
As a supplement for promoting hair health, Shi-Bi-Man (SBM) is prescription comprising various traditional Chinese medicines. Though SBM has been reported to promote regeneration, its molecular mechanism remains unclear. Cynomolgus monkeys (Macaca fascicularis) are non-human primates with gene expression profile similar that of humans. The purpose this research evaluate the effect on regeneration in cynomolgus and reveal underlying mechanism.The was observed by skin administration 6...
Abstract Objective: In this study, we screened for therapeutic targets of the Xian-Lian-Jie-Du decoction (XLJDD) colorectal cancer (CRC) and explored underlying mechanisms using network pharmacology techniques. Methods: Genes associated with CRC were collected from GeneCards database. The names active compounds XLJDD used as keywords in “chemical name” Traditional Chinese Medicine Systems Pharmacology (TCMSP) database to search targets. protein–protein interaction (PPI) was constructed...
In warehousing logistics, the sorting and transportation efficiency of goods is still one important factors limiting rapid development logistics. At present, most regions use manual with low high cost. Especially in some special work areas, such as temperatures, severe electronic radiation, areas heavy long-term tasks, urgent need for small robots to replace labor. order solve inconvenience that places logistics only sorting, It necessary design a small-sized weight robot, which can wait...
<sec> <title>BACKGROUND</title> Background: Syndrome differentiation plays a crucial role in traditional Chinese medicine (TCM) diagnosis and treatment planning. However, this process is highly dependent on expert experience, thereby limiting systematically standardization. </sec> <title>OBJECTIVE</title> Objective: The present study established Bidirectional Encoder Representations from Transformers (BERT)-based TCM syndrome model (PCSD-BERT) with validation using in-house pancreatic cancer...
Esophageal gastrointestinal stromal tumors(GISTs) are extremely rare. We sought to determine whether endoscopic treatment can be a viable therapeutic option for esophageal GISTs.A total of 20 cases with histological diagnosis GISTs were obtained from our center between 2008 and 2020. Data on the clinicopathological features recorded.There 9 males (45%) 11 females (55%) in this study, median age 56 years. The tumors preferentially occurred middle lower parts thoracic esophagus (45 40%,...
The stress relaxation behavior and creep rupture property of GH4145 alloy were studied.The results show that has good resistance to relaxation.During the test at 566 ºC, coarsening rate secondary γ′ particles was very slow hardness increased due increase in volume fraction dispersed precipitation tertiary particles.The relational expression between life for ºC obtained.The strength times longer than experimental data can be estimated by using this equation.
Abstract Background : As a supplement for promoting hair health, Shi-Bi-Man (SBM) is natural product comprising various traditional Chinese medicines. Though SBM has been reported to promote regeneration, its molecular mechanisms remains unclear. Cynomolgus monkeys (Macaca fascicularis) are non-human primates with gene expression profile similar that of humans. The purpose this research evaluate the effect on regeneration in cynomolgus and reveal underlying mechanism. Methods was observed by...
Abstract Background Psoriasis is a chronic inflammatory genetic disease, mainly manifesting in the skin. Conventional therapies, such as glucocorticosteroids and corticosteroids, have adverse effects that limit drug use. Hence, it imperative to identify new therapeutic strategy exhibits favorable safety profile. Shi-Bi-Man (SBM) safe herbal supplement sourced from various natural plants, including ginseng, angelica sinensis, polygonum multiflorum, aloe vera. Purpose We aimed find potential...