Sean C. Thomas

ORCID: 0009-0003-7030-1810
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About
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Research Areas
  • Amino Acid Enzymes and Metabolism
  • Mitochondrial Function and Pathology
  • Microbial Inactivation Methods
  • Diet and metabolism studies
  • Microbial Metabolic Engineering and Bioproduction
  • Microfluidic and Bio-sensing Technologies
  • Transboundary Water Resource Management
  • Enzyme Structure and Function
  • Cancer, Hypoxia, and Metabolism
  • Chronic Disease Management Strategies
  • Aluminum toxicity and tolerance in plants and animals
  • Biblical Studies and Interpretation
  • Pancreatic function and diabetes
  • Probiotics and Fermented Foods
  • Historical and Religious Studies of Rome
  • Jewish Identity and Society
  • Medical Research and Practices
  • Metabolism and Genetic Disorders
  • Electoral Systems and Political Participation
  • Adipose Tissue and Metabolism
  • Sirtuins and Resveratrol in Medicine
  • Social Policy and Reform Studies
  • Pediatric health and respiratory diseases
  • Alzheimer's disease research and treatments
  • Adenosine and Purinergic Signaling

Palm Beach Atlantic University
2023-2024

NOSM University
2023

Virginia Tech - Wake Forest University School of Biomedical Engineering & Sciences
2023

Micro Focus (United States)
2021-2022

Virginia Tech
2019-2020

Laurentian University
2013-2019

California Lutheran University
2012

Background Irreversible electroporation (IRE) has been previously investigated in preclinical trials as a treatment for intracranial malignancies. Here, we investigate next generation high-frequency irreversible (H-FIRE), both monotherapy and combinatorial therapy, the of malignant gliomas. Methods Hydrogel tissue scaffolds numerical modeling were used to inform in-vivo H-FIRE pulsing parameters our orthotopic tumor-bearing glioma model. Fischer rats separated into five cohorts including...

10.3389/fonc.2023.1171278 article EN cc-by Frontiers in Oncology 2023-05-05

Treatment of intracranial disorders suffers from the inability to accumulate therapeutic drug concentrations due protection blood–brain barrier (BBB). Electroporation-based therapies have demonstrated capability permeating BBB, but knowledge longevity BBB disruption (BBBD) is limited. In this study, we quantify temporal, high-frequency electroporation (HFE)-mediated BBBD in an vivo healthy rat brain model. 40 male Fisher rats underwent HFE treatment; two blunt tipped monopolar electrodes...

10.3390/cancers11121850 article EN Cancers 2019-11-23

The significance of metabolic networks in guiding the fate stem cell differentiation is only beginning to emerge. Oxidative metabolism has been suggested play a major role during this process. Therefore, it critical understand underlying mechanisms alterations occurring cells manipulate ultimate outcome these pluripotent cells. Here, using P19 murine embryonal carcinoma as model system, mitochondrial biogenesis and modulation dimethyl sulfoxide (DMSO)-induced are revealed. Blue native...

10.1089/cell.2013.0049 article EN Cellular Reprogramming 2013-12-19

Glycerol is an important by-product of the biodiesel industry and its transformation into value-added products being actively pursued in order to improve efficacy this renewable energy sector. Here we report that enhanced production α-ketoglutarate (KG) effected by Pseudomonas fluorescens a mineral medium supplemented with manganese (Mn) propelled increased activities succinate semialdehyde dehydrogenase (SSADH), γ-aminobutyric acid aminotransaminase (GABAT), isocitrate lyase (ICL). The...

10.3389/fmicb.2019.01929 article EN cc-by Frontiers in Microbiology 2019-08-23

The Tridentine Latin Mass (TLM) is rapidly growing in popularity. movement that has formed around it grown so attached to as threaten the unity of Catholic Church. I attended TLMs multiple distinct settings, studied worshippers’ ordinary theology, and proceeded hermeneutically using Circle Method. most useful insight emerge from this theological aesthetics post-Conciliar could be more deeply symbolic synergistic with Conciliar intellectual theology. TLM’s offer worshippers assurances...

10.3390/rel15040439 article EN cc-by Religions 2024-03-31

U.S. Catholics in recent decades have been given the choice between Republicans and Democrats, representing two parties whose platforms diverge significantly from Catholic social teaching (CST). The American Solidarity Party (ASP) was founded on same principles as CST, particularly consistent respect for dignity of human life, including safeguards support poor, vulnerable, oppressed. Thus, it offers voters, well many other constituencies, an alternative that can greatly reduce their...

10.54561/prj1702353t article EN cc-by-nc-sa POLITICS AND RELIGION JOURNAL 2023-10-25

Abstract OBJECTIVE Treatment of CNS disorders suffer from the inability to deliver large therapeutic agents brain parenchyma due protection blood-brain barrier (BBB). High-frequency electroporation (HFE) employs a series high voltage pulsed electric fields disrupt BBB and/or ablate tumor tissue while sparring proteinaceous structures. Pulsing parameters pulse width and intra-phase delay can be modulated reduce excitation muscle nervous tissues, though this is inherently accompanied by an...

10.1093/neuonc/noaa215.887 article EN Neuro-Oncology 2020-11-01

In this wide-ranging work, editors Judith Baskin and Kenneth Seeskin have enlisted an impressive roster of scholars to provide introduction many areas Jewish life from its origins in ancient Israel contemporary times—and even beyond (the final essay the volume points forward “The Future World Communities”). While various periods, practices, textual corpora covered work will doubtless find it be critical value, especially useful those teaching courses introducing aspects Judaism at...

10.1093/jaarel/lfs019 article EN Journal of the American Academy of Religion 2012-05-04
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