A5105964602- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Microbial infections and disease research
- Biosensors and Analytical Detection
- Bacterial Genetics and Biotechnology
- Listeria monocytogenes in Food Safety
Hebrew University of Jerusalem
2024-2025
Introduction: Pseudomonas aeruginosa is an opportunistic pathogen that causes health care-associated infections. The rise of antibiotic-resistant bacterial strains necessitates alternative treatment strategies, with bacteriophage therapy being a promising approach.
Background: Antibiotic-resistant Pseudomonas aeruginosa (P. aeruginosa) strains are an increasing cause of morbidity and mortality. Pulsed blue light (PBL) enhances porphyrin-induced reactive oxygen species has been clinically shown to be harmless the skin at low doses. Bacteriophages, viruses that infect bacteria, offer a promising non-antibiotic bactericidal approach. This study investigates potential synergism between low-dose PBL phage therapy against P. in planktonic cultures preformed...
Abstract Introduction Pseudomonas aeruginosa is a major opportunistic pathogen associated with healthcare-associated infections. The rise of antibiotic-resistant strains necessitates alternative treatment strategies, bacteriophage therapy being promising approach. Methods Six bacteriophages were isolated from sewage samples. Phage isolation involved centrifugation, filtration, and plaque assays. morphology each was examined using Transmission Electron Microscopy (TEM). Genomic DNA sequenced...
Abstract Antibiotic-resistant Pseudomonas aeruginosa (PA) is a critical health threat. Novel treatment approaches are urgently required in this post-antibiotic era. In the current study, we investigated bactericidal combinatorial potential of two non-antibiotic alternative approaches: phage therapy and pulsed blue light (PBL). Bacteriophages (phages), viruses that specifically infect lyse bacteria without harming eukaryotic cells. Pulsed (PBL) alters bacterial membranes was clinically shown...