A5065179426- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Genetics, Aging, and Longevity in Model Organisms
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Pluripotent Stem Cells Research
- Genomics and Chromatin Dynamics
Center for Life Sciences
2025
Tsinghua University
2022-2025
Molecular Oncology (United States)
2025
McGovern Institute for Brain Research
2025
State Key Laboratory of Molecular Oncology
2024-2025
Chinese Institute for Brain Research
2023-2024
In chronic viral infections, sustained CD8+ T cell response relies on TCF1+ precursor-exhausted cells (TPEX) exhibiting stem-like properties. TPEX self-renew and respond to PD-1 blockade, underscoring their paramount importance. However, strategies for effectively augmenting remain limited. Here, we demonstrate that ZC3H12A deficiency initiates a stemness program in but also increases death, whereas BCOR predominantly promotes proliferation. Consequently, co-targeting of both imparts...