A5101616202- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Glycosylation and Glycoproteins Research
- Genetics and Physical Performance
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Skin Protection and Aging
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- S100 Proteins and Annexins
- interferon and immune responses
- Congenital heart defects research
- Cancer-related Molecular Pathways
- Microbial Inactivation Methods
- Cardiac Fibrosis and Remodeling
- Tea Polyphenols and Effects
- Spectroscopy Techniques in Biomedical and Chemical Research
- Tuberculosis Research and Epidemiology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Connective Tissue Growth Factor Research
- Advanced Biosensing Techniques and Applications
- Biosensors and Analytical Detection
- Galectins and Cancer Biology
- Heme Oxygenase-1 and Carbon Monoxide
- Natural Compounds in Disease Treatment
Yangtze University
2025
Chinese PLA General Hospital
2025
Qilu Hospital of Shandong University
2019-2024
Anhui University of Traditional Chinese Medicine
2023
The First Affiliated Hospital, Sun Yat-sen University
2021-2022
Zhongshan Hospital
2021-2022
Fudan University
2021-2022
Sun Yat-sen University
2021-2022
Tsinghua University
2022
Guang Fu Hospital
2022
Enhancer binding protein AP-4 is a transcription factor that activates both viral and cellular genes by to the symmetrical DNA sequence, CAGCTG. Here, we report molecular cloning characterization of human cDNAs. The deduced amino acid sequence reveals helix-loop-helix (HLH) protein. Like other members this family, HLH motif adjacent basic domain are necessary sufficient confer site-specific binding. However, unlike proteins, also contains two additional dimerization motifs consisting leucine...
Circular RNAs (circRNAs) are endogenous non‑coding implicated in atherosclerosis. The aim of the present study was to explore function circRNA‑0044073 Reverse transcription quantitative polymerase chain reaction assays were used measure expression levels circRNA‑0044073, microRNA (miRNA/miR)‑107, janus kinase 1 (JAK1), signal transducer and activator 3 (STAT3), B‑cell lymphoma 2 (Bcl‑2) v‑myc avian myelocytomatosis viral oncogene homolog (c‑myc) blood cells from patients with RNA pull‑down...
Although photothermal therapy (PTT) can induce antitumour immunity, the mechanisms underlying its effects in pancreatic cancer (PC) require further exploration. In this study, mechanism of action PTT and connection to pyroptosis as well therapeutic potential alone combination with STING agonists, were investigated. addition, a biomarker PC was found stratify patients who are suitable for PTT. We explored whether vitro evaluated efficacy immunity-inducing ability combined agonist (c-di-GMP)...
Objective This study was aimed to evaluate the anti-photoaging effects of baicalin on Ultraviolet B (UVB)-induced photoaging in dorsal skin hairless mice and premature senescence human dermal fibroblasts. Methods We established vivo vitro models by repeated exposures UVB irradiation. By HE staining, masson immunohistostaing real-time RT-PCR, we analyzed epidermal thickness, collagen expression mRNA protein levels type I collagen, III interstitial collagenase (MMP-1 MMP-3) exposed skin. The...
Ecological cultivation is an important way for the sustainable production of traditional Chinese medicine in context carbon peaking and neutrality goals. Facility simulative habitat modes have been developed applied to develop endangered Dendrobium huoshanense on basis protection. However, differences greenhouse gas emissions global warming potential these remain unexplored, which limits accurate assessment carbon-friendly ecological D. huoshanense. Greenhouse emission flux monitoring based...
This study aims to examine the association between proliferator‐activated receptor γ ( PGC )‐gene family‐related single nucleotide polymorphisms SNP s) and elite endurance runners' status in a C hinese cohort, gain insights into functionality of subset SNPs . Genotype distributions 133 s PPARGC1A , PPARGC1B PPRC 1 TFAM TFB1M TFB2M NRF1 GABPA GABPB1 ERR α SIRT genes were compared 235 H an) runners (127 women) 504 healthy non‐athletic controls (237 women). Luciferase gene reporter activity was...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Li Y, Wang L, Yi et al. ACTN3 R577X genotype and performance of elite middle-long distance swimmers in China. Biology Sport. 2017;34(1):39-43. doi:10.5114/biolsport.2017.63731. APA Li, Y., Wang, L., Yi, Liu, J., Hu, & Lu, Y. (2017). Sport, 34(1), 39-43. https://doi.org/10.5114/biolsport.2017.63731 Chicago LQ L J Y M Wang. 2017. "ACTN3 China". Sport 34 (1): Harvard M. pp.39-43. MLA China." vol. 34, no. 1, 2017,...
Previous studies indicated that G-protein coupled receptor 174 (GPR174) is involved in the dysregulated immune response of sepsis, however, clinical value and effects GPR174 septic patients are still unknown. This study aimed to evaluate potential as a prognostic biomarker for sepsis explore pathological function cecal ligation puncture (CLP)-induced mice. In this prospective longitudinal study, expressions peripheral mRNA were measured 101 patients, 104 non-septic ICU controls, 46 healthy...
Abstract (Ca 1‐x Eu x )WO 4 (x = 0–21 mol%) phosphors were prepared using the classical solid‐state reaction method. The influence of 3+ ion doping on lattice structure was observed powder X‐ray diffraction and Fourier transform infrared spectroscopy. Furthermore, under this influence, luminescence properties all samples analyzed. results clearly illustrated that element europium successfully incorporated into CaWO with a scheelite in form ion, which introduced slight distortion matrix....
ANXA2, a member of the annexin family, is overexpressed and plays important roles in tumor development. However, significance ANXA2 expression gastric carcinoma has not been clarified.To elucidate its growth cancer, SGC-7901 cells was inhibited with designated siRNA, then cell proliferation, cycling, apoptosis motility were determined by MTT assay, flow cytometry, Hoechst 33342 staining wound healing respectively. To further assess behavior deleted SGC- 7901 cells, changes microstructures...
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease that leads to respiratory failure, and for which there no effective treatment. Apolipoprotein A-1 (ApoA-1) has been reported ameliorate the bleomycin (BLM)-induced IPF model.To examine function of D-4F, an ApoA-1 mimetic polypeptide, in IPF, we used in-vivo BLM-induced model. We assigned mice into following 3 groups: Blank Group (BLK Group), Bleomycin Treatment (Model D-4F Interference (Inter Group). The was examined by...
Abstract In mice, only the zygotes and blastomeres from 2-cell embryos are authentic totipotent stem cells (TotiSCs), capable of producing all cell types in both embryonic extraembryonic tissues forming an entire organism 1 . However, it remains challenging whether how TotiSCs, representing very beginning a life, can be established vitro absence germline cells. Here, we described step-by-step protocol for induction long-term maintenance TotiSCs mouse pluripotent (PSCs) by small-molecule...
To explore the genetic basis for two patients from a family with BCL11A-related intellectual disability (BCL11A-ID).Clinical data of proband and her members was analyzed. Chromosomal karyotyping analysis, trio-whole exome sequencing (trio-WES) copy number variation (CNV-seq) were carried out. For suspected variants, Sanger used to verify, pathogenicity assessment conducted.The mother both had language impairment, their fetal hemoglobin (HbF) significantly elevated. A heterozygous...
This study investigates the potential of TPX2 in mitigating diabetic cardiomyopathy by modulating Akt/FoxO1 signaling pathway. Diabetic was induced rats using streptozotocin, and heart structure function were assessed through echocardiography HE staining. expression myocardial tissue measured qRT-PCR. Lentivirus used to overexpress specifically tissue, followed reassessment cardiac function. Immunohistochemical staining employed evaluate Caspase3 expression. In group, rat hearts exhibited...
Our objective was to study the cytocidal and inhibitory effect of energy controllable pulse on ovarian cancer cell line SKOV3. An suspension treated by electric pulses with different parameters. Inhibitory rate (IR) assayed modified colorimetric MTT methods. Growth curves two test groups one control group were also measured, morphological changes observed under transmission electron microscopy (TEM). Treated SKOV3 proliferated more slowly. IR promoted enhancement each parameter. The showed...
Objective To evaluate the effect of miRNA-23a silencing on ultraviolet B (UVB)-induced chronic photodamage to fibroblasts.Methods Fibroblasts from human foreskin were divided into four groups:blank control group receiving untreated,UVB UVB irradiation only,miRNA-23a transfected with a antagomir,UVB + transfection antagomir followed by irradiation.UVB was carried out once day for five consecutive days at dose 10 mJ/cm2.Three after last irradiation,SA-β-galactosidase staining performed detect...
Objective To observe the effect of sirolimus,an autophagy enhancer,on premature senescence in fibroblasts induced by repeated exposure to a subtoxic dose ultraviolet B (UVB).Methods Skin from foreskin tissue healthy adolescents were classified into six groups:control group cultured Dulbecco's modified Eagles' medium (DMEM) containing 1％ calf serum,UVB receiving UVB irradiation only,sirolimus treated with sirolimus 10 mg/L (added after daily exchange culture medium),and three combined groups...