A5088142456- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Neuroblastoma Research and Treatments
- Muscle Physiology and Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Hematological disorders and diagnostics
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Esophageal Cancer Research and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Polyomavirus and related diseases
- Acute Lymphoblastic Leukemia research
- Inflammatory Myopathies and Dermatomyositis
- Multiple and Secondary Primary Cancers
- Retinoids in leukemia and cellular processes
- Diabetic Foot Ulcer Assessment and Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Body Contouring and Surgery
- Neurogenetic and Muscular Disorders Research
Newcastle University
2021-2024
National Institutes of Health
2023
Center for Cancer Research
2023
National Cancer Institute
2023
King's College Hospital
2023
Johnson University
2021-2022
Rutgers, The State University of New Jersey
2021-2022
Rutgers Cancer Institute of New Jersey
2021
Northside Hospital
2021
Great North Children's Hospital
2021
PURPOSE Adult post-transplantation lymphoproliferative disease (PTLD) has a reported 3-year overall survival (OS) of 35% to 40%. The impact rituximab on the outcome PTLD is not well defined. METHODS We examined clinical features and outcomes among large cohort solid organ transplantation (SOT) -related patients with who were recently treated at four Chicago institutions (from January 1998 2008). Results Eighty identified had median SOT-to-PTLD time 48 months (range, 1 216 months). All...
Abstract Despite hypercellular bone marrows (BM), peripheral cytopenias are the rule in patients with myelodysplastic syndromes (MDS). This study examined roles played by cell birth and death rates generating this paradox. Cell kinetics from BM biopsies of 35 MDS were measured using intravenous infusions either iododeoxyuridine or bromodeoxyuridine, both. Degree apoptosis programmed (PCD) was estimated situ end‐labeling DNA directly biopsies, which simultaneously double‐labeled for...
Data on outcome, prognostic factors, and treatment for very elderly non-Hodgkin lymphomas (NHL) is sparse. We conducted a multicentre retrospective analysis of NHL patients ≥80 years (at diagnosis) treated between 1999 2009. Detailed characteristics were obtained including geriatric syndromes, activities daily living (ADLs), co-morbidities using the Cumulative Illness Rating Scale-Geriatrics (CIRS-G). identified 303 patients: 170 aggressive (84% B cell/16% T cell) 133 indolent (82% cell/18%...
Inclusion body myositis is the most common progressive muscle wasting disease in people older than 50 years, with no effective drug treatment. Arimoclomol an oral co-inducer of cellular heat shock response that was safe and well-tolerated a pilot study inclusion myositis, reduced key pathological markers two in-vitro models representing degenerative inflammatory components this disease, improved pathology function mutant valosin-containing protein mice. In current study, we aimed to assess...
Regulation of expression interleukin 7 (IL-7) mRNA is aberrant in the leukemic subset cells chronic lymphocytic leukemia (CLL) patients. The entire coding sequence for IL-7 as well an alternatively spliced are transcribed these cells. No detected fresh peripheral blood mononuclear from normal individuals. Furthermore, "normal" nonleukemic subsets isolated same CLL patients also do not express mRNA. only which one that contains themselves. polymerase chain reaction was used to examine...
Background The guinea-pig proximal colon contains semi-solid feces which are propelled by intermittent neural peristaltic waves to the distal colon, where solid pellets formed. Between propulsive periods, complex motor patterns underlie fluid re-absorption and mixing of contents. Methods Spatio-temporal analysis video recordings were used investigate myogenic non-peristaltic activity. Key Results At low distension (6 cmH2O), two major seen. Narrow rings constriction (abrupt contractions)...
<h3>Background</h3> Quality of life (QoL) assessment allows healthcare professionals to appreciate the patient perspective their disease. This can help us make a better choice from among various ways we currently measure severity muscle disease such as inclusion body myositis (IBM). However, cannot assume that QoL in IBM is just related psychosocial factors may play an important role determining QoL. <h3>Methods</h3> Sixty subjects with had assessments and concurrent mood using Short-Form 36...
Clinical trials in Duchenne muscular dystrophy (DMD) require 3-6 months of stable glucocorticoids, and the primary outcome is explored at 48-52 weeks. The factors that influence clinical assessment (COA) trajectories soon after glucocorticoid initiation are relevant for design analysis novel drugs. We describe early COA trajectories, associated factors, time from to peak.
ABSTRACT Transplanted hematopoietic stem cells (HSC) regenerate more rapidly in the femoral marrow of lethally irradiated hosts pretreated with cyclophosphamide (CY) 4 days prior to X‐irradiation than they do that uninjected (control). On other hand, regeneration HSC transplanted into given CY 7 before is slower controls. The microenvironment was studied at various times after giving CY. Four injecting CY, number colony forming units (CFU), total nucleated cells, and mature myeloid erythroid...
Pseudotumor cerebri (PTC) patients exhibit clear clinical signs and symptoms of higher intracranial pressure (ICP) without ventricular enlargement or mass lesions. The picture with PTC can sometimes be similar to that Chiari Malformation type I (CMI). There is some evidence malformation may coexist, which raises the question whether an idiopathic disease a complication posterior decompression surgery-treatment choice for malformation.A retrospective review electronic medical records...
There is no data on safety and efficacy of a second course ibritumomab tiuxetan. In this work, patients with B-cell NHL who were treated two courses tiuxetan analyzed. Eighteen such analyzed (age: 58 years, 48 – 91), median four prior regimens (1 7), stem cell transplantation (n = 5), radiation therapy 6). After the first course, G3/4 neutropenia thrombocytopenia was 35% 41%; overall response rate (ORR) 89%; time between 16.6 months (6.0 42.7). incidence 28% 44%; ORR 77%. infectious or...
Abstract Background The effects of the coronavirus disease 2019 (COVID‐19) pandemic on surgical oncology practice are not yet quantified. aim this study was to measure immediate impact COVID‐19 volume. Methods A retrospective patients treated at an NCI‐Comprehensive Cancer Center performed. “Pre‐COVID” era defined as January–February 2020 and “COVID” March–April 2020. Primary outcomes were clinic visits operative volume by subspecialty. Results Abouyt 907 new patient visits, 3897 follow‐up...