A5089340804- Advanced Biosensing Techniques and Applications
- RNA regulation and disease
- Herpesvirus Infections and Treatments
- Influenza Virus Research Studies
- Autoimmune Neurological Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Diabetes and associated disorders
Bruker (United States)
2024-2025
University of Leeds
2003
Vitamin B12 is critical for hematopoiesis and myelination. Deficiency can cause neurologic deficits including loss of coordination cognitive decline. However, diagnosis relies on measurement vitamin in the blood, which may not accurately reflect concentration brain. Using programmable phage display, we identified an autoantibody targeting transcobalamin receptor (CD320) a patient with progressive tremor, ataxia, scanning speech. Anti-CD320 impaired cellular uptake cobalamin (B12) vitro by...
Abstract Antibody drug conjugates (ADCs) are an innovative class of biopharmaceuticals which combine the potency cytotoxic molecules with targeted specificity monoclonal antibodies. The success a traditional ADC not only hinges on tumor antigen-specific binding but internalization to maximize cytotoxicity from payload and minimize off-target damage healthy tissue. development therapy is complex, multistep process that involves identifying target antigen, discovering ideal antibody, selecting...