A5100761820- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Liver Disease Diagnosis and Treatment
- CAR-T cell therapy research
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Ovarian cancer diagnosis and treatment
- Blood groups and transfusion
- Aquaculture Nutrition and Growth
- Antioxidant Activity and Oxidative Stress
- Hydrogen's biological and therapeutic effects
- Hemoglobinopathies and Related Disorders
- Plant Parasitism and Resistance
- Face recognition and analysis
- Galectins and Cancer Biology
- MRI in cancer diagnosis
- Islanding Detection in Power Systems
- Animal Disease Management and Epidemiology
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- Proteins in Food Systems
Southern Medical University
2025
Lanzhou University Second Hospital
2018-2025
Lanzhou University
2018-2025
Sun Yat-sen University
2012-2025
Sichuan University
2025
Sun Yat-sen Memorial Hospital
2012-2025
Nanfang Hospital
2025
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
2024
Anhui University of Traditional Chinese Medicine
2024
Qingdao University of Science and Technology
2024
Chimeric antigen receptor (CAR) T cell is a promising method in cancer immunotherapy but faces many challenges solid tumors. One of the major problems was immunosuppression caused by PD-1. In our study, expression c-Met GC analyzed from TCGA datasets, tissues, and lines. The CAR second-generation with 4-1BB, cMet-PD1/CD28 adding PD1/CD28 chimeric-switch (CSR). vitro, we measured changes different subgroups, phenotypes PD-1 CAR-T cells. We detected secretion levels cytokines killing ability...
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality, largely due to late-stage diagnosis. Reliable early detection methods are critically needed. PDAC-derived extracellular vesicles (EVs) carry molecules that reflect their parental tumor cells and detectable in disease stages, offering promising noninvasive diagnostic approach. Here, streamlined PDAC EV Surface Protein Assay for quantifying subpopulations 300-µL plasma through two-step workflow presented:...
Abstract Ultraviolet B (UVB) is one of the most common triggers cutaneous lupus erythematosus (CLE), but mechanism still unclear. Here, we discovered that expression macrophage migration inhibitory factor (MIF), a multipotent cytokine, was significantly increased in keratinocytes patients scRNA-seq data and clinical samples. We further UVB exposure induced MIF releasing from contributed to tissue remodeling inflammation by regulating matrix metalloproteinases (MMPs) pro-inflammatory...
Neutrophils, an essential innate immune cell type with a short lifespan, rely on continuous replenishment from bone marrow (BM) precursors. Although it is established that neutrophils are derived the granulocyte-macrophage progenitor (GMP), molecular regulators involved in differentiation process remain poorly understood. Here we developed random forest-based machine-learning pipeline, NeuRGI (Neutrophil Regulatory Gene Identifier), which utilized Positive-Unlabeled Learning (PU-learning)...
To genetically characterize a case of neonatal complete androgen insensitivity syndrome (CAIS) and identify the underlying molecular defect. This was retrospective analysis clinical data, diagnosis, treatment CAIS in Second Hospital Lanzhou University. Genetic testing patient their parents done; pathogenic genes child were detected using whole exome sequencing (WES) technology. The social sex proband female, but chromosomal male. WES Exon 1 deletion mutation AR gene heterozygosity mother....
Abstract With the continuous progress of technology, subject life science plays an increasingly important role, among which application artificial intelligence in medical field has attracted more and attention. Bell facial palsy, a neurological ailment characterized by muscle weakness or paralysis, exerts profound impact on patients’ expressions masticatory abilities, thereby inflicting considerable distress upon their overall quality mental well-being. In this study, we designed attribute...
Surgical removal is the primary treatment for liver cancer, but frequent recurrence caused by residual malignant tissue remains an important challenge, as leads to high mortality. It unreliable distinguish tumors from normal tissues merely under visual inspection. Hyperspectral imaging (HSI) has been proved be a promising technology intra-operative use capturing spatial and spectral information of in fast, non-contact label-free manner. In this work, we investigated feasibility HSI tumor...
Background: To investigate the potential effects of molecular hydrogen on ovarian cancer.Methods: The in vivo study was performed using Hs38.T xenografted BALB/c nude mice. mean tumor volume monitored during 6 weeks inhalation. Immunohistochemistry (IHC) staining to determine Ki67 and CD34 expression. vitro proliferation PA-1 were determined by Cell Counting Kit (CCK)-8 assay. Matrigel invasion assay cell ability. Wounding employed examine motile nature cancer cells. Colony formation effect...
The therapeutic strategies for advanced gastric cancer (GC) remain unsatisfying and limited. Therefore, it is still imperative to fully elucidate the mechanisms underlying GC aggressive progression. prognostic value biological functions of low density lipoprotein receptor class A domain containing protein 2 (LDLRAD2) in have never been studied yet. We found that LDLRAD2 expression was significantly upregulated closely correlated with poor prognosis patients. Functionally, promoted...
Hemolysis is a common feature in patients with β-thalassemia major. As result, autoimmune hemolytic anemia complicating easily overlooked. Here, the authors described clinical features and management of 7 major anemia. These had fever, cough, tea-colored urine on admission. The laboratory investigations showed significant drop hemoglobin increased serum bilirubin. Coombs' tests revealed that anti-immunoglobulin G (IgG) anti-C3 was positive 5 cases, respectively, whereas anti-Rh E...
Abstract Background Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have considerably high mortality and re-hospitalisation rate. Diaphragmatic dysfunction (DD) is common in COPD patients. However, whether diaphragmatic related to acute exacerbation yet be elucidated. This study aimed evaluate the diaphragm function by magnetic resonance imaging (MRI) patients assess impact DD may help predict AECOPD. Methods 20 healthy adult volunteers 80 were enrolled. The diaphragms...