A5092152650- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Opioid Use Disorder Treatment
- Pain Mechanisms and Treatments
University of Pennsylvania
2023-2024
Children's Hospital of Philadelphia
2021
Abstract Objective Clinicians use intracranial electroencephalography (iEEG) in conjunction with noninvasive brain imaging to identify epileptic networks and target therapy for drug‐resistant epilepsy cases. Our goal was promote ongoing future collaboration by automating the process of “electrode reconstruction,” which involves labeling, registration, assignment iEEG electrode coordinates on neuroimaging. We developed a standalone, modular pipeline that performs reconstruction. demonstrate...
Abstract Objective Epilepsy patients are often grouped together by clinical variables. Quantitative neuroimaging metrics can provide a data‐driven alternative for grouping of patients. In this work, we leverage ultra‐high‐field 7‐T structural magnetic resonance imaging (MRI) to characterize volumetric atrophy patterns across hippocampal subfields and thalamic nuclei in drug‐resistant focal epilepsy. Methods Forty‐two epilepsy 13 controls with were included study. We measured subfield...
Collaboration between epilepsy centers is essential to integrate multimodal data for research. Scalable tools rapid and reproducible analysis facilitate multicenter integration harmonization. Clinicians use intracranial EEG (iEEG) in conjunction with non-invasive brain imaging identify epileptic networks target therapy drug-resistant cases. Our goal was promote ongoing future collaboration by automating the process of "electrode reconstruction," which involves labeling, registration,...
Studies of intracranial EEG networks have been used to reveal seizure generators in patients with drug-resistant epilepsy. Intracranial is implanted capture the epileptic network, collection brain tissue that forms a substrate for seizures start and spread. Interictal measures activity at baseline, computed during this state can aberrant without requiring recordings. network analyses require choosing reference applying statistical functional connectivity. Approaches these technical choices...
Abstract Patients with drug-resistant temporal lobe epilepsy often undergo intracranial EEG recording to capture multiple seizures in order lateralize the seizure onset zone. This process is associated morbidity and ends postoperative recurrence. Abundant interictal (between-seizure) data are captured during this process, but these currently play a small role surgical planning. Our objective was predict laterality of zone using patients epilepsy. We performed retrospective cohort study...
ABSTRACT Patients with drug-resistant temporal lobe epilepsy often undergo intracranial EEG recording to capture multiple seizures in order lateralize the seizure onset zone. This process is associated morbidity and ends postoperative recurrence. Abundant interictal (between-seizure) data captured during this process, but these currently play a small role surgical planning. Our objective was predict laterality of zone using patients epilepsy. We performed retrospective cohort study...
Functional magnetic resonance imaging (fMRI) offers an alternative to the traditional Wada test for presurgical language and memory lateralization that carries almost no risk. However, fMRI of episodic remains challenging because hippocampus, which is fundamental memory, smaller, more prone susceptibility artifact, harder functionally modulate than regions. We previously showed a complex scene task can lateralize function in mesial temporal lobe. Using data acquired from N = 45 patients with...