Graphene oxide (GO) is widely used in various fields and considered to be relatively biocompatible. Herein, “indirect” nanotoxicity first defined as toxic amplification of toxicants or pollutants by nanomaterials. This work revealed that GO greatly amplifies the phytotoxicity arsenic (As), a widespread contaminant, wheat, for example, causing decrease biomass root numbers increasing oxidative stress, which are thought regulated its metabolisms. Compared with As alone, combined inhibited...

Mitochondria are the main intracellular location for fuel generation; however, they not just power plants but involved in a range of other functions including regulation redox homeostasis and cell fate. Dysfunction mitochondria will result oxidative stress which is one underlying causal factors variety diseases neurodegenerative diseases, diabetes, cardiovascular cancer. In this paper, generation reactive oxygen/nitrogen species (ROS/RNS) mitochondria, regulatory roles certain mitochondrial...

Graphene-related research has intensified rapidly in a wide range of disciplines, but few studies have examined ecosystem risks, particularly phytotoxicity. This study revealed that graphene significantly inhibits the number wheat roots and biosynthesis chlorophyll, altered morphology shoots. Humic acid (HA), ubiquitous form natural organic matter, (P < 0.05) relieved this phytotoxicity recovered sharp shoot tips. Both graphene–HA were transferred from to shoots found cytoplasms...

An indoor smog chamber facility has been built for carrying out secondary organic aerosol (SOA) formation and studying physicochemical properties of SOA. This comprises ~7 m3 FEP Teflon reactor placed in temperature controlled room coupled with instruments gas particle phase data. Detailed characterization experiments have presented describing control temperature, relative humidity (RH), effective mixing time, wall loss rates gases particles, light source, air purification. showed a wide...

Low visibility weather easily leads to traffic accidents, posing threats human life and property. To accurately forecast visibility, we conduct an empirical study focusing on Jiangsu Province. Firstly, collect the monitoring data from meteorological stations environmental for 2017-2018. Secondly, analyze changes in both spatial temporal perspectives. Next, maximum Relevance Minimum Redundancy (mRMR) algorithm is employed select factors affecting finding that humidity

Although our previous studies have confirmed that 1, 3, 8-trihydroxy-6-methylant hraquinone (emodin) inhibits migration and invasion in epithelial ovarian cancer (EOC) cells, the underlying molecular mechanism remains unknown. Here, aim was to investigate effects of emodin on EOC cells study further this process, both vitro vivo.Cell proliferation evaluated by methylthiazolyl tetrazolium assay. Cell abilities were tested using transwell The expression integrin-linked kinase (ILK)...

Penthorum chinense has been used in both food and medication for many years, polysaccharide of which was considered as one the bioactive compounds. However, extraction process from P. (PCP) not well optimized. Ultrasound-assisted extractionhas widely employed natural products its compliance with concept green economic chemistry. To better investigate structure biology activity PCP, response surface methodology to optimize ultrasound-assisted conditions PCP. The optimum PCP were obtained...

Cell fate regulation is a function of diverse cell signaling pathways that promote survival and or inhibit death execution. In this regard, the role Bcl-2 family in maintaining tight balance between proliferation has been extensively studied. The conventional dogma links by to its effect on mitochondrial permeabilization apoptosis amplification. However, recent evidence provide novel mechanism for via modulating cellular redox metabolism. For example overexpression shown contribute...

The demethylation of methylmercury has received substantial attention. Here, a novel chemical method for the is proposed. low-toxicity graphene-fulvic acid (FA, ubiquitous material in environment) was synthesized without use reagent. hybridized graphene-FA presented an indirect open band gap 2.25-2.87 eV as well adequate aqueous dispersion. More importantly, exhibited 6- and 10-fold higher photocatalytic efficiencies than FA free with graphene, respectively. This result implies that...

In the dairy industry, glutamine (Gln) is often used as a feed additive to increase milk yield and quality; however, molecular regulation underneath needs further clarification. Here, with bovine mammary epithelial cells (BMECs), effects mechanisms of Gln on cell growth casein synthesis were assessed. When was added or depleted from BMECs, both β-casein (CSN2) expression increased decreased, respectively. Overexpressing inhibiting mechanistic target rapamycin (mTOR) revealed that regulated...

Abstract Recombinant collagen holds immense potential in the development of medical functional materials, yet its widespread application remains hindered by absence a suitable self-assembly strategy. In this article, we report discovery that bacterial-derived collagen-like (CL) protein Scl2 can rapidly self-gelation (∼1 min at pH ∼7) due to properties enabled metal coordination crosslinking. This was achieved fusing ion chelating peptides both termini protein. Our research further reveals...

Based on the conventional cleaning methods (water (WC) + brush (BC)), this study evaluated influence of ultrasonic (UC) collecting various sized particulate matter (PM) retained leaf surfaces. We further characterized retention efficiency leaves to PM, which will help assess abilities urban trees remove PM from ambient air quantitatively. Taking three broadleaf tree species (Ginkgo biloba, Sophora japonica, and Salix babylonica) two needleleaf (Pinus tabuliformis Sabina chinensis) as...

Mass concentrations of chemical constituents (organics, nitrate, sulfate, ammonium, chloride, and black carbon (BC)) the number size distribution submicrometer particles in ambient atmosphere were continuously measured urban Gwangju, Korea, during Megacity Air Pollution Studies (MAPS)-Seoul campaign. Organics (9.1 μg/m3) most dominant species, followed by sulfate (4.7 μg/m3), nitrate (3.2 ammonium (2.6 BC (1.3 (particulate matter less than 1 μm (PM1)). The potential source regions located...

<title>Abstract</title> Hemodynamic cues are thought to control blood vessel hierarchy through a shear stress set point, where flow increases lead diameter expansion, while decreases in cause narrowing. Aberrations can congenital arteriovenous malformations (AVMs). We show zebrafish embryos that arteries behave according the point model, veins do not. This behavior is dependent on distinct arterial and venous endothelial cell (EC) shapes sizes. ECs enlarge more strongly when experiencing...

Abstract We recently reported a novel mechanism of anti-apoptotic activity Bcl-2 by demonstrating link between an altered mitochondrial metabolism and apoptosis resistance in cells overexpressing Bcl-21. This increase was linked to induction complex IV (Cytochrome C oxidase) as well oxygen consumption2. The pro-oxidant function interaction with the small GTPase Rac1. validated number clinical tissues derived from patients aggressive B cell lymphomas. Interestingly, interrupting Rac1 restored...

Abstract We have recently reported a novel mechanism linking the pro-oxidant activity of anti-apoptotic protein Bcl-2 to its interaction with small GTPase Rac1. In this current study, we investigate nature using activated (GTP loaded) Rac1 and peptides (spanning BH3 domain adjacent loop region) coimmunoprecipitation, isothermal titration calorimetry (ITC), X-ray crystallography, docking/modeling, fluorescence spectroscopy, molecular dynamics mutational studies. Our results will develop...