Richard Sheppard
A5034871729- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Cardiac pacing and defibrillation studies
- COVID-19 epidemiological studies
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Hormonal Regulation and Hypertension
- Viral Infections and Outbreaks Research
- Cardiovascular and exercise physiology
- COVID-19 Clinical Research Studies
- Anesthesia and Pain Management
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiac Fibrosis and Remodeling
- Frailty in Older Adults
- Hip and Femur Fractures
- Disaster Response and Management
Imperial College London
2020-2025
Medical Research Council
2025
Imperial Valley College
2024
McGill University
2011-2023
Jewish General Hospital
2011-2023
Hartford Hospital
1996-2023
London Centre for Neglected Tropical Disease Research
2023
Hartford Financial Services (United States)
2023
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
Peripartum cardiomyopathy shares some clinical features with idiopathic dilated cardiomyopathy, a disorder caused by mutations in more than 40 genes, including TTN, which encodes the sarcomere protein titin.
The effects of spinal anesthesia as compared with general on the ability to walk in older adults undergoing surgery for hip fracture have not been well studied.
Background: Peripartum cardiomyopathy (PPCM) occurs in ≈1:2000 deliveries the United States and worldwide. The genetic underpinnings of PPCM remain poorly defined. Approximately 10% women with harbor truncating variants TTN (TTNtvs). Whether mutations other genes can predispose to is not known. It also known if presence TTNtvs predicts clinical presentation or outcomes. Nor it prevalence differs preeclampsia, strongest risk factor for PPCM. Methods: Women were retrospectively identified from...
Background: The REGAIN (Regional versus General Anesthesia for Promoting Independence after Hip Fracture) trial found similar ambulation and survival at 60 days with spinal general anesthesia hip fracture surgery. Trial outcomes evaluating pain, prescription analgesic use, patient satisfaction have not yet been reported. Objective: To compare surgery anesthesia. Design: Preplanned secondary analysis of a pragmatic randomized trial. (ClinicalTrials.gov: NCT02507505) Setting: 46 U.S. Canadian...
Peripartum cardiomyopathy (PPCM) is an idiopathic form of pregnancy-induced heart failure associated with preeclampsia. Circulating factors in late pregnancy are thought to contribute both diseases, suggesting a common underlying pathophysiological process. However, what drives this process remains unclear. Using serum proteomics, we identified the senescence-associated secretory phenotype (SASP), marker cellular senescence biological aging, as most highly up-regulated pathway young women...
Peripartum cardiomyopathy has variable disease progression and left ventricular (LV) recovery. We hypothesized that baseline right (RV) size function are associated with LV recovery outcome.Investigations of Pregnancy-Associated Cardiomyopathy was a prospective 30-center study 100 peripartum women ejection fraction (LVEF) <45% within 13 weeks after delivery. Baseline RV assessed by echocardiographic end-diastolic area, end-systolic fractional area change, tricuspid annular plane excursion,...
<h3>Importance</h3> The prevalence of nonischemic dilated cardiomyopathy (DCM) is greater in individuals African ancestry than European ancestry. However, little known about whether the difference or outcomes associated with functional genetic variants. <h3>Objective</h3> We hypothesized that Bcl2-associated anthanogene 3 (<i>BAG3</i>) variants were DCM. <h3>Design</h3> This multicohort study the<i>BAG3</i>genotype patients uses DNA obtained from American enrolled clinical studies: Genetic...
Background The effects of spinal versus general anesthesia on long-term outcomes have not been well studied. This study tested the hypothesis that is associated with better survival and functional recovery than anesthesia. Methods A prespecified analysis was conducted a completed randomized superiority trial compared for hip fracture repair. Participants included previously ambulatory patients 50 yr age or older at 46 U.S. Canadian hospitals. Patients were 1:1 to anesthesia, stratified by...
Quality of life (QoL) is an important end point in heart failure (HF) studies. The Minnesota Living with Heart Failure questionnaire (MLHFQ) the instrument most widely used to evaluate QoL patients. It a containing 21 questions scores ranging from 0 105. A best cut-off value for MLHFQ identify those patients good, moderate or poor has not been determined.To determine score based on neural network (NN) approach. These will help discriminate between HF having QoL.This research was carried out...
In the context of modern cancer chemotherapeutics, survivors are living longer and being exposed to potential comorbidities related non-cancer side effects such treatments. With close monitoring patients receiving potentially cardiotoxic medical therapies, oncologists cardiologists alike identifying in both clinical subclinical phases cardiovascular disease chemotherapies. Specifically, cardiotoxicity at level myocardium for development heart failure becoming a growing concern with...
Black women are at greater risk for peripartum cardiomyopathy (PPCM). The guanine nucleotide-binding proteins β-3 subunit (GNB3) has a polymorphism C825T. GNB3 TT genotype more prevalent in blacks is associated with poorer outcomes. We evaluated and myocardial recovery PPCM.A total of 97 PPCM were enrolled genotyped the T/C polymorphism. Left ventricular ejection fraction (LVEF) was assessed by echocardiography entry, 6 12 months postpartum. LVEF over time subjects compared those C allele...
Total hip arthroplasty (THA) is associated with pulmonary embolization of cement-bone marrow debris leading to cardiopulmonary complications including cardiac arrest. These are more prevalent during revision THA. This report assessed right ventricular function using a ejection fraction artery catheter (RVEF) and transesophageal echocardiography (TEE) in 18 patients undergoing During femoral prosthesis insertion, all exhibited hemodynamic changes, but most these were small clinically...
The etiology of peripartum cardiomyopathy remains unknown. One hypothesis is that an increase in the 16-kDa form prolactin pathogenic and suggests breastfeeding may worsen by increasing prolactin, while bromocriptine, which blocks release, be therapeutic. An autoimmune has also been proposed. authors investigated impact on cellular immunity myocardial recovery for women with IPAC (Investigations Pregnancy Associated Cardiomyopathy) study. Women who breastfed had elevated levels correlated...