Karen Hanley‐Yanez
A5048923173- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Cardiomyopathy and Myosin Studies
- Heart Failure Treatment and Management
- Receptor Mechanisms and Signaling
- Pregnancy and preeclampsia studies
- Cardiac Fibrosis and Remodeling
- Pregnancy-related medical research
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- Pulmonary Hypertension Research and Treatments
- Fuel Cells and Related Materials
- Cardiac electrophysiology and arrhythmias
- Hormonal Regulation and Hypertension
- Allergic Rhinitis and Sensitization
- Transplantation: Methods and Outcomes
- Pharmacogenetics and Drug Metabolism
- Metabolism and Genetic Disorders
- Signaling Pathways in Disease
- Dermatology and Skin Diseases
- Cardiovascular Effects of Exercise
- Birth, Development, and Health
- Organ Transplantation Techniques and Outcomes
- Pharmacological Effects and Assays
University of Pittsburgh
2010-2024
University of Pittsburgh Medical Center
2016-2024
UPMC Health System
2018
Jewish General Hospital
2016
McGill University
2016
University of Calgary
2016
University of Southern California
2016
Vanderbilt University
2016
Cleveland Clinic
2016
University of Maryland, Baltimore
2016
Peripartum cardiomyopathy shares some clinical features with idiopathic dilated cardiomyopathy, a disorder caused by mutations in more than 40 genes, including TTN, which encodes the sarcomere protein titin.
Peripartum cardiomyopathy (PPCM) is an idiopathic form of pregnancy-induced heart failure associated with preeclampsia. Circulating factors in late pregnancy are thought to contribute both diseases, suggesting a common underlying pathophysiological process. However, what drives this process remains unclear. Using serum proteomics, we identified the senescence-associated secretory phenotype (SASP), marker cellular senescence biological aging, as most highly up-regulated pathway young women...
<h3>Importance</h3> The prevalence of nonischemic dilated cardiomyopathy (DCM) is greater in individuals African ancestry than European ancestry. However, little known about whether the difference or outcomes associated with functional genetic variants. <h3>Objective</h3> We hypothesized that Bcl2-associated anthanogene 3 (<i>BAG3</i>) variants were DCM. <h3>Design</h3> This multicohort study the<i>BAG3</i>genotype patients uses DNA obtained from American enrolled clinical studies: Genetic...
Relaxin is a 6 kDa protein hormone produced by the corpus luteum and secreted into blood during pregnancy in rodents humans. Growing evidence indicates that circulating relaxin causes vasodilatation increases arterial compliance, which may be among its most important actions pregnancy. Here we investigated whether there local expression function of receptor arteries nonpregnant females males. Relaxin-1 major receptor, Lgr7, mRNA are expressed thoracic aortas, small renal mesenteric from mice...
Black women are at greater risk for peripartum cardiomyopathy (PPCM). The guanine nucleotide-binding proteins β-3 subunit (GNB3) has a polymorphism C825T. GNB3 TT genotype more prevalent in blacks is associated with poorer outcomes. We evaluated and myocardial recovery PPCM.A total of 97 PPCM were enrolled genotyped the T/C polymorphism. Left ventricular ejection fraction (LVEF) was assessed by echocardiography entry, 6 12 months postpartum. LVEF over time subjects compared those C allele...
The etiology of peripartum cardiomyopathy remains unknown. One hypothesis is that an increase in the 16-kDa form prolactin pathogenic and suggests breastfeeding may worsen by increasing prolactin, while bromocriptine, which blocks release, be therapeutic. An autoimmune has also been proposed. authors investigated impact on cellular immunity myocardial recovery for women with IPAC (Investigations Pregnancy Associated Cardiomyopathy) study. Women who breastfed had elevated levels correlated...
The endothelial endothelin B (ET(B)) receptor subtype is critical for renal vasodilation induced by relaxin in nonpregnant rats and during pregnancy (the latter via endogenous circulating relaxin). Here we tested whether expression of vascular ET(B) protein regulated relaxin. Small arteries were harvested from virgin midterm pregnant as well that administered recombinant human (rhRLX) at 4 mug/h or vehicle 5 d 4-6 h. dissected additional incubated vitro with rhRLX 3 h 37 C. was also...
Objective To examine the association between maternal obesity on left ventricular (LV) size and recovery in women with peripartum cardiomyopathy (PPCM). Study Design This was a prospective analysis of 100 enrolled within 13 weeks PPCM diagnosis followed for year Investigation Pregnancy Associated Cardiomyopathy study. Adiposity defined by standard body mass index (BMI) definitions under/normal weight, overweight, obesity. Demographic, clinical, biomarker variables were compared across weight...
In this report, we present data on heterogeneity of rat NK cells utilizing a combination antibody and lectin-binding characteristics. Among NKR-P1bright cells, two discrete populations characterized as Lycopersicon esculentum lectin (L.E.)bright (60 to 80%) L.E.dim (20 40%) were identified by flow cytometry. Comparison the morphology sorted NKR-P1bright/L.E.bright NKR-P1bright/L.E.dim indicated that both greater than 90% LGL. An analysis functional capabilities sub-populations more efficient...
Evaluate the relationship of cathepsin-D (CD) on disease severity and clinical outcomes for women with peripartum cardiomyopathy. Cathepsin-D is a protease released during oxidative stress that cleaves prolactin (PRL) generating 16 kDa fragment pro-apoptotic, anti-angiogenic, has been implicated in pathogenesis cardiomyopathy (PPCM). In 99 newly diagnosed PPCM enrolled Investigation Pregnancy Associated Cardiomyopathy (IPAC) study, CD levels were assessed by ELISA from serum obtained at...
( N Engl J Med . 2016;374:233–241) It is possible that peripartum cardiomyopathy influenced by genetic factors, though this remains unclear. Similar to idiopathic dilated cardiomyopathy, disease associated with decreased systolic function, enlarged cardiac dimensions, and nonspecific histologic findings. These similarities are significant in has been shown be caused a number of gene mutations. The authors study sequenced the DNA 172 women suffering from investigate whether there was...
Background Cardiovascular dysfunction and hypertension can persist postpartum following hypertensive disorders of pregnancy (HDPs). This study hypothesized that activin A, proinflammatory markers concentric remodeling by echo would be higher 1-2 years HDP with persistent compared to normalized blood pressure (BP). We further correlations between biomarkers BP echocardiographic indices. Methods Results enrolled participants HDPs but no prepregnancy followed 1 2 after delivery. Activin A...