A5028316449- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Trauma Management and Diagnosis
- Viral-associated cancers and disorders
- Trauma and Emergency Care Studies
- Inflammatory Bowel Disease
- HIV Research and Treatment
- Cardiac Arrest and Resuscitation
- Cancer-related molecular mechanisms research
- Spinal Fractures and Fixation Techniques
- Pharmacological Effects of Medicinal Plants
- Traumatic Brain Injury and Neurovascular Disturbances
- Extracellular vesicles in disease
- Psoriasis: Treatment and Pathogenesis
- HIV-related health complications and treatments
- CAR-T cell therapy research
- Eosinophilic Esophagitis
- RNA Research and Splicing
- Pharmaceutical studies and practices
- Ubiquitin and proteasome pathways
- Immunodeficiency and Autoimmune Disorders
- Restraint-Related Deaths
- Cancer-related gene regulation
- Atmospheric chemistry and aerosols
- Traumatic Ocular and Foreign Body Injuries
Johnson & Johnson (United States)
2022-2025
Janssen (Switzerland)
2025
Janssen Scientific Affairs (United States)
2025
Broward Health
2022-2024
Evonik (Germany)
2022-2024
Broward Health Medical Center
2019-2024
Janssen (United States)
2024
Florida International University
2016-2023
Luxembourg Institute of Health
2023
University of Arizona
2023
Significance Exceedingly high levels of fine particulate matter (PM) occur frequently in China, but the mechanism severe haze formation remains unclear. From atmospheric measurements two Chinese megacities and laboratory experiments, we show that oxidation SO 2 by NO occurs efficiently aqueous media under polluted conditions: first, during 1952 London Fog via in-cloud oxidation; second, on PM with NH 3 neutralization China. We suggest effective mitigation is achievable intervening sulfate...
We show that the microRNA miR-155 can be processed from sequences present in BIC RNA, a spliced and polyadenylated but non-protein-coding RNA accumulates lymphoma cells. The precursor of is likely transient or unspliced nuclear transcript rather than accumulated which primarily cytoplasmic. By using sensitive quantitative assay, we find clinical isolates several types B cell lymphomas, including diffuse large (DLBCL), have 10- to 30-fold higher copy numbers do normal circulating Similarly,...
Brain Injury Guidelines (BIG) was developed to effectively use health care resources including repeat head computed tomography (RHCT) scan and neurosurgical consultation in traumatic brain injury (TBI) patients. The aim of this study prospectively validate BIG at a multi-institutional level.This is prospective, observational, trial across nine Levels I II trauma centers. Adult (16 years or older) blunt TBI patients with positive initial (CT) were identified categorized into 1, 2, 3 based on...
Neuroinflammation in the brain contributes to pathogenesis of Parkinson's disease (PD), but potential dysregulation peripheral immunity has not been systematically investigated for idiopathic PD (iPD). Here we showed an elevated cytotoxic immune milieu, with more terminally-differentiated effector memory (TEMRA) CD8 T, CD8+ NKT cells and circulating molecules fresh blood patients early-to-mid iPD, especially females, after analyzing > 700 innate adaptive features. This profile, also...
Interdigitating dendritic cell sarcoma (IDCS) is a rare tumor derived from interdigitating cells. Three cases of IDCS associated with chronic lymphocytic leukemia/small lymphoma (CLL/SLL) have been described, but no clonal relationship between the 2 neoplasms was demonstrated. We present detailed case analysis CLL/SLL metachronous and demonstrate that these are clonally related. The CLL cells had trisomy 12 identical monoclonal immunoglobulin heavy chain gene rearrangements. Analysis...
The heterogeneous chemistry of glyoxal on sulfuric acid surfaces has been investigated at various concentrations and temperatures, utilizing a low-pressure fast flow laminar reactor coupled to an ion drift-chemical ionization mass spectrometer (ID-CIMS). uptake coefficient (γ) ranges from (1.2 ± 0.06) × 10(-2) (2.5 0.01) 10(-3) for 60-93 wt % H2SO4 253-273 K. effective Henry's Law constant (H*) (98.9 4.9) 10(5) (1.6 0.1) M atm(-1) 263-273 Both the increase with decreasing concentration...
Abstract Specialized pro‐resolving mediators (SPM), primarily produced in innate immune cells, exert crucial bioactions for resolving inflammation. Among various lipoxygenases (LOX), 15‐LOX‐1 is key SPM biosynthesis, but cellular activation principles of are unexplored. It was shown that 3‐ O ‐acetyl‐11‐keto‐ β ‐boswellic acid (AKBA) shifts 5‐LOX regiospecificity from 5‐ to 12‐lipoxygenation products. Here, it demonstrated AKBA additionally activates via an allosteric site accomplishing...
A "strategy" for analyte capture/ionization based on chemical derivatization of gold nanorods and infrared laser desorption ionization (IR-LDI) is described. This the first example desorption/ionization biomolecules using irradiated with an IR laser. LDI performed at wavelengths (1064 nm) that overlap longitudinal surface plasmon resonance (LSPR) mode nanorods. The absorbed energy from facilitates analyte. wavelength LSPR band can be tuned by controlling aspect ratio (length-to-diameter)...
BACKGROUND Unlike the cervical spine (C-spine), where National Emergency X-Radiography Utilization Study (NEXUS) and Canadian C-spine Rules can be used, evidence-based thoracolumbar (TL-spine) clearance guidelines do not exist. The aim of this study was to develop a clinical decision rule for evaluating TL-spine after injury. METHODS Adult (≥15 years) blunt trauma patients were prospectively enrolled at 13 US centers (January 2012 January 2014). Exclusion criteria included following: injury...
Abstract Background Early biologic treatment is associated with better outcomes in pts CD. GALAXI 2 & 3 are identically designed trials assessing the efficacy and safety of guselkumab (GUS), a dual-acting IL-23p19 subunit inhibitor, moderately to severely active CD, BIO-naïve was previously reported.1,2,3 Here, we present results post-hoc analysis GUS disease duration ≤2yrs using data from pooled trials. Methods Pts had CD (based on CDAI SES-CD) history inadequate response/intolerance...
Opiate abuse increases the risk of HIV transmission and exacerbates neuropathology by increasing inflammation modulating immune cell function. Exosomal EVs(xEV) contain miRNAs that may be differentially expressed due to infection or opiate abuse. Here we develop a preliminary exosomal-miRNA biomarker profile HIV-infected PBMCs in context use. infected with were treated dosages morphine for 72 hours, culture supernatants collected, exosomes isolated using differential centrifugation....
Introduction: Frankincense preparations are frequently used as traditional anti-inflammatory remedies in folk medicine with increasing popularity. Boswellic acids (BAs), especially 3-O-acetyl-11-keto-βBA (AKBA), unique principles of frankincense, multiple pharmacological actions and target proteins. We recently showed that AKBA favorably impacts lipid mediator (LM) networks innate immune cells, by modulation lipoxygenase (LOX) activities. Thus, binds to allosteric sites 5-LOX, shifting the...
A single-center, randomized, double-blind, controlled clinical trial with four arms was conducted in healthy subjects persistent knee discomfort (pain intensity on 1–10 cm visual analog scale (VAS) > 3) aged 40 years and older treated a dietary supplement for 8 weeks. The study groups were Boswellia serrata extract (n = 29), an omega-3-based product (AvailOm® 50 High EPA) 31), + AvailOm® 30), placebo 30). intake of improved the quality life (QoL) (WOMAC index) some variables muscle...
BACKGROUND Single institution studies have shown that clinical examination of the cervical spine (c-spine) is sensitive for clearance c-spine in blunt trauma patients with distracting injuries. Despite an unclear definition, most centers still adhere to notion injuries adversely affect sensitivity examination. A prospective AAST multi-institutional trial was performed assess screening awake and alert METHODS During 42-month study period, 18 years older were prospectively evaluated a standard...
Prehospital identification of the injured patient likely to require emergent care remains a challenge. End-tidal carbon dioxide (ETCO2) has been used in prehospital setting monitor respiratory physiology and confirmation endotracheal tube placement. Low levels ETCO2 have demonstrated correlate with injury severity mortality number in-hospital studies. We hypothesized that values would be predictive need for massive transfusion (MT) intubated patients.This was retrospective multicenter trial...
Civilian mass shooting events (CMSE) are occurring with increased frequency. Unfortunately, our knowledge of how to respond these is largely based on military experience and medical examiner data. While this translational has improved basic response such events, it critical that we have a better under-standing the wound patterns observed resources utilized in civilian shootings. This will allow us prepare systems for future events.Patients from two consecutive CMSEs presented same level 1...