A5028877127- Trauma and Emergency Care Studies
- Abdominal Trauma and Injuries
- Cardiac Arrest and Resuscitation
- Effects of Radiation Exposure
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Spaceflight effects on biology
- Urological Disorders and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma Management and Diagnosis
- Radiation Therapy and Dosimetry
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Abdominal Surgery and Complications
- Pelvic and Acetabular Injuries
- Anesthesia and Neurotoxicity Research
- Aortic Disease and Treatment Approaches
- Esophageal and GI Pathology
- Stress Responses and Cortisol
- Sexual Assault and Victimization Studies
- Glutathione Transferases and Polymorphisms
- Bariatric Surgery and Outcomes
- Hydrogen's biological and therapeutic effects
- Child Abuse and Trauma
- Abdominal vascular conditions and treatments
- Circadian rhythm and melatonin
Loma Linda University
2015-2025
Cooper University Health Care
2018-2023
Cornell University
2023
The University of Texas at Austin
2023
ORCID
2023
Loma Linda University Medical Center
2010-2022
University of Maryland, Baltimore
2018-2021
Via Christi Hospital
2021
Ascension Via Christi
2021
Maine Medical Center
2021
Spaceflight conditions have a significant impact on number of physiological functions due to psychological stress, radiation, and reduced gravity. To explore the effect flight environment immunity, C57BL/6NTac mice were flown 13-day space shuttle mission (STS-118). In response flight, animals had reduction in liver, spleen, thymus masses compared with ground (GRD) controls (P < 0.005). Splenic lymphocyte, monocyte/macrophage, granulocyte counts significantly (FLT) 0.05). Although spontaneous...
The immune system is highly sensitive to stressors present during spaceflight. major emphasis of this study was on the T lymphocytes in C57BL/6NTac mice after return from a 13-day space shuttle mission (STS-118). Spleens and thymuses flight animals (FLT) ground controls similarly housed animal enclosure modules (AEM) were evaluated within 3-6 h landing. Phytohemagglutinin-induced splenocyte DNA synthesis significantly reduced FLT when based both counts per minute stimulation indexes (P <...
Blunt thoracic aortic injuries (BTAIs) are composed of a spectrum lesions ranging from intimal tear to rupture, yet optimal management and ultimate outcome have not been clearly established.This is retrospective multicenter study BTAIs January 2008 December 2013. Demographics, diagnosis, treatment, in-hospital outcomes were analyzed.Nine American College Surgeons-verified Level I trauma centers contributed data 453 patients with BTAIs. After exclusion expiring before imaging (58) transfers...
Aortic occlusion (AO) is a lifesaving therapy for the treatment of severe traumatic hemorrhagic shock; however, there remains controversy whether AO should be accomplished via resuscitative thoracotomy (RT) or endovascular balloon aorta (REBOA) in zone 1.To compare outcomes RT vs REBOA 1.This was comparative effectiveness research study using multicenter registry postinjury from October 2013 to September 2021. 1 (above celiac artery) compared with performed emergency department facilities...
Pneumatosis intestinalis (PI) is associated with numerous adult conditions, ranging from benign to life threatening. To date, series of PI outcomes consist case reports and small retrospective series.We conducted a multicenter study, involving eight centers, January 2001 December 2010. Demographics, medical history, clinical presentation, were collected. Primary outcome was the presence pathologic defined as confirmed transmural ischemia at surgery or withdrawal care subsequent mortality....
Introduction: Hemorrhage is one of the leading causes death in trauma victims. Historically, paramedics have not had access to medications that specifically target reversal trauma-induced coagulopathies. The California Prehospital Antifibrinolytic Therapy (Cal-PAT) study seeks evaluate safety and efficacy tranexamic acid (TXA) use civilian prehospital setting cases traumatic hemorrhagic shock. Methods: Cal-PAT a multi-centered, prospective, observational cohort with retrospective comparison....
Despite the widespread institution of modern massive transfusion protocols with balanced blood product ratios, survival for patients traumatic hemorrhage receiving ultramassive (UMT) (defined as ≥20 U packed red cells [RBCs]) in 24 hours) remains low and resource consumption high. Therefore, we aimed to identify factors associated mortality trauma UMT resuscitation era.An Eastern Association Surgery Trauma multicenter retrospective study 461 from 17 centers who received RBCs hours was...
Occupational exposure is an important consideration during emergency department thoracotomy (EDT). While human immunodeficiency virus/hepatitis prevalence in trauma patients (0-16.8%) and occupational rates operative procedures (1.9-18.0%) have been reported, risk EDT unknown. We hypothesized that would be greater than other procedures.A prospective, observational study at 16 US centers was performed (2015-2016). All bedside resuscitation providers were surveyed with a standardized data...
Estimating the prevalence of harassment, verbal abuse, and discrimination among residents is difficult as events are often under-reported. The purpose this study was to determine abuse surgical using HITS (Hurt, Insulted, Threatened with harm or Screamed at) screening tool. A multicenter, cross-sectional, survey-based conducted at five academic teaching hospitals. Of 310 residents, 76 (24.5%) completed survey. tool positive in 3.9 per cent. most common forms included sexual harassment...
Our group has previously published a retrospective review defining variables predictive of transmural bowel ischemia in the setting pneumatosis intestinalis (PI). We hypothesize this prospective study will confirm findings review, enhancing legitimacy to factors for pathologic PI highlighted.Data were collected using Research Electronic Data Capture. Forward logistic regression was utilized identify independent predictors PI. Statistical significance defined as p ≤ 0.05.During 3-year period,...
The health consequences of exposure to low-dose radiation combined with a solar particle event during space travel remain unresolved. goal this study was determine whether protracted alters gene expression and oxidative burst capacity in the liver, an organ vital many biological processes. C57BL/6 mice were whole-body irradiated 2 Gy simulated (SPE) protons over 36 h, both without pre-exposure low-dose/low-dose-rate photons ((57)Co, 0.049 total at 0.024 cGy/h). Livers excised immediately...
A better understanding of low dose radiation effects is needed to accurately estimate health risks. In this study, C57BL/6 mice were gamma-irradiated total doses 0, 0.01, 0.05, and 0.1 Gy ((57)Co; ~0.02 cGy/h). Subsets per group euthanized at the end irradiation (day 0) on days 4 21 thereafter. Relative spleen mass splenic white blood cell (WBC) counts, major leukocyte populations, spontaneous DNA synthesis consistently higher in irradiated groups day 0 compared controls, although...
To determine whether differences exist between proton and electron radiations on biological responses after total-body exposure.ICR mice (n=45) were irradiated to 2 Gray (Gy) using fully modulated 70 MeV protons (0.5 Gy/min) 21 electrons (3 Gy/min). At 36 h post-irradiation liver gene expression, white blood cell (WBC), natural killer (NK) other analyses performed.Oxidative stress-related expression patterns strikingly different for groups compared 0 Gy (P<0.05). Proton radiation...
With a relative shortage of type AB plasma, many centers have converted to A plasma for resuscitation patients whose blood is unknown. The goal this study determine outcomes trauma who received incompatible transfusions as part massive transfusion protocol (MTP). METHODS As an Eastern Association the Surgery Trauma multi-institutional trial, registry and bank data were collected from eight (age, ≥ 15 years) receiving emergency release MTPs January 2012 August 2016. Incompatible was defined...
The management of high-grade renal trauma (HGRT) and the indications for intervention are not well defined. American Association Surgery Trauma (AAST) grading does incorporate some important clinical radiologic variables associated with increased risk interventions. We aimed to use data from a multi-institutional contemporary cohort develop nomogram predicting interventions bleeding after HGRT.From 2014 2017, on adult HGRT (AAST grades III-V) were collected 14 level 1 centers. Patients both...
Purpose: To evaluate cluster of differentiation 4+ (CD4+) T cell gene expression and related parameters after whole-body exposure to proton radiation as it occurs in the spaceflight environment.Materials methods: C57BL/6 mice were irradiated total doses 0, 0.01, 0.05, 0.1 gray (Gy) at cGy/h. On day 0 spleens harvested from a subset 0.01 Gy groups; cells isolated; 84 genes relevant helper (Th) function was determined using reverse transcriptase-polymerase chain reaction (RT-PCR). Remaining...
The goal was to characterize differences in cell response after exposure active beam scanning (ABS) protons compared a passive delivery system. Human lung epithelial (HLE) cells were evaluated at various locations along the proton depth dose profile. delivered Bragg peak position essentially identical (∼4 Gy) with two techniques, but data showed that ABS resulted lower doses entry and more rapid drop-off peak. Average rates for beams 1.1 Gy/min 5.1 Gy/min, respectively; instantaneous 19.2...
Health risks due to exposure low-dose/low-dose-rate radiation alone or when combined with acute irradiation are not yet clearly defined. This study quantified the effects of protracted γ rays and without protons on response immune other cell populations. C57BL/6 mice were irradiated 57Co (0.05 Gy at 0.025 cGy/h); subsets subsequently exposed high-dose/high-dose-rate proton (250 MeV; 2 3 0.5 Gy/min). Analyses performed 4 17 days postexposure. Spleen thymus masses relative body mass decreased...
A single-center trial recently demonstrated a prevalence of 14% intimate partner and sexual violence (IPSV) among both male female trauma patients, regardless mechanism injury. We aimed to determine if this phenomenon was similar rates in other centers by assessing the feasibility universal screening determining association IPSV with trauma-associated comorbidities.We designed an Eastern Association for Surgery Trauma-supported multicenter, prospective observational cohort study involving...
The treatment of esophageal perforation (EP) remains a significant clinical challenge. While number investigators have previously documented efficient approaches, these were mostly single-center experiences reported prior to the introduction newer technologies: specifically endoluminal stents. This study was designed document contemporary practice in diagnosis and management EP at multiple institutions around world includes early outcomes. A five-year (2009–2013) multicenter retrospective...
No AccessJournal of UrologyAdult Urology1 Sep 2020Current Management Extraperitoneal Bladder Injuries: Results from the Multi-Institutional Genito-Urinary Trauma Study (MiGUTS)This article is commented on by following:Editorial CommentEditorial Comment Ross E. Anderson, Sorena Keihani, Rachel A. Moses, Alexander P. Nocera, J. Patrick Selph, Clara M. Castillejo Becerra, Nima Baradaran, Katie Glavin, Joshua Broghammer, Chirag S. Arya, L. Sensenig, Michael Rezaee, Bradley Morris, Sarah...