A5044039628- Neuroinflammation and Neurodegeneration Mechanisms
- Trauma and Emergency Care Studies
- Immune cells in cancer
- Extracellular vesicles in disease
- Trauma Management and Diagnosis
- Abdominal Trauma and Injuries
- Alzheimer's disease research and treatments
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Tryptophan and brain disorders
- Emergency and Acute Care Studies
- Cardiac Arrest and Resuscitation
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Inflammasome and immune disorders
- Hip and Femur Fractures
- Sphingolipid Metabolism and Signaling
- Glaucoma and retinal disorders
- Advanced Glycation End Products research
- Trace Elements in Health
- Complement system in diseases
- Drug Transport and Resistance Mechanisms
- Luminescence and Fluorescent Materials
- Immune Response and Inflammation
- COVID-19 Impact on Reproduction
Purdue University West Lafayette
2019-2025
University of Chicago
2018-2025
National Institute of Mental Health and Neurosciences
2024
Christ University
2024
Alabama College of Osteopathic Medicine
2024
University College London
2017-2024
Princess Alexandra Hospital NHS Trust
2019-2023
New York University
2023
University of Chicago Medical Center
2023
Kerala Veterinary and Animal Sciences University
2020
Secondary hospital-acquired fungal infections are common in critically-ill patients and mortality remains high despite antimicrobial therapy. Interleukin-7 (IL-7) is a potent immunotherapeutic agent that improves host immunity has shown efficacy bacterial viral models of infection. This study examined the ability IL-7, which currently multiple clinical trials (including hepatitis human immunodeficiency virus), to improve survival clinically relevant 2-hit model sepsis.Mice underwent cecal...
ABSTRACT The sepsis syndrome represents an improper immune response to infection and is associated with unacceptably high rates of mortality morbidity. interactions between T cells the innate system while combating are poorly understood. In this report, we observed that treatment potent, antiapoptotic cytokine interleukin-7 (IL-7) accelerated neutrophil recruitment improved bacterial clearance. We first determined were necessary for previously IL-7-mediated enhanced survival. Next, IL-7...
BACKGROUND Microparticles (MPs) are 0.3 μm to 1.0 vesicles generated after cell activation or apoptosis that may play a role in the pathophysiology of sepsis. We sought elucidate MPs patients with critical illness and hypothesized at site inflammation can modulate immune response. METHODS Surgical ongoing sepsis were enrolled from intensive care unit an urban, Level I trauma center March June 2011. Abdominal washings bronchoalveolar lavage fluid collected sites inflammation. isolated using...
Several microglia-expressed genes have emerged as top risk variants for Alzheimer's disease (AD). Impaired microglial phagocytosis is one of the main proposed outcomes by which these AD-risk may contribute to neurodegeneration, but mechanisms translating genetic association cellular dysfunction remain unknown. Here we show that microglia form lipid droplets (LDs) upon exposure amyloid-beta (Aβ), and their LD load increases with proximity amyloid plaques in brains from human patients AD mouse...
Astrocytes respond to injury, infection, and inflammation in the central nervous system by acquiring reactive states which they may become dysfunctional contribute disease pathology. A sub-state of astrocytes induced proinflammatory factors TNF, IL-1α, C1q ("TIC") has been implicated many neurodegenerative diseases as a source neurotoxicity. Here, we used an established human pluripotent stem cell (hiPSC) model investigate surface marker profile proteome TIC-induced astrocytes. We propose...
The natural history of traumatic hemothorax (HTX) remains unclear. We aimed to describe outcomes HTX following tube thoracostomy drainage and delineate factors that predict progression a retained (RH). hypothesized initial large-volume predicts the development an RH.We conducted prospective, observational, multi-institutional study adult trauma patients diagnosed with identified on computed tomography (CT) scan volumes calculated at time diagnosis. All were managed within 24 hours...
Occupational exposure is an important consideration during emergency department thoracotomy (EDT). While human immunodeficiency virus/hepatitis prevalence in trauma patients (0-16.8%) and occupational rates operative procedures (1.9-18.0%) have been reported, risk EDT unknown. We hypothesized that would be greater than other procedures.A prospective, observational study at 16 US centers was performed (2015-2016). All bedside resuscitation providers were surveyed with a standardized data...
Glial cell phagocytosis of pH-dependent amyloid-β, Aβ pH , in live and fixed cultures, brain tissue sections, retina, cortex animals useful for studying function health disease.
Abstract The management of traumatic injuries requires the coordinated efforts a multidisciplinary team trauma surgeons, subsurgical specialties, intensivists, and interventionalists. interventional radiologist plays critical role in acute by offering 24-hour consultation, expert imaging interpretation, an array life-saving minimally invasive procedures. As integrated members clinical team, should be able to review information, communicate clearly with consulting services, perform timely...
We aimed to assess 24-month outcomes of wearing an organic light-emitting sleep mask as intervention treat and prevent progression non-central diabetic macular oedema.CLEOPATRA was a phase 3, single-blind, parallel-group, randomised controlled trial undertaken at 15 ophthalmic centres in the UK. Adults with non-centre-involving oedema were randomly assigned (1:1) either light during (Noctura 400 Sleep Mask, PolyPhotonix Medical, Sedgefield, UK) or sham (non-light) mask, for 24 months....
The neutrophil/lymphocyte ratio (NLR) has been associated as a predictor for increased mortality in critically ill patients. We sought to determine the relationship between NLR and outcomes adult trauma patients with severe hemorrhage requiring initiation of massive transfusion protocol (MTP). hypothesized that would be prognostic indicator this population.This was multi-institutional retrospective cohort study (≥18 years) who received MTP November 2014 2015. Differentiated blood cell counts...
Background/Aims Prospective data on switching anti-vascular endothelial growth factors in patients with neovascular age-related macular degeneration (nAMD) who have previously shown no/partial response are limited. This prospective study assessed the effect of from aflibercept to ranibizumab anatomical and functional outcomes persistent/recurrent disease activity. Methods SAFARI ( NCT02161575 ) was a 6-month, prospective, single-arm conducted UK Germany. Patients, meeting strict eligibility...
Abstract Astrocytes are a heterogeneous population of central nervous system glial cells that respond to pathological insults and injury by undergoing transformation called “reactivity.” Reactive astrocytes exhibit distinct context‐dependent cellular, molecular, functional state changes can either support or disturb tissue homeostasis. We recently identified reactive astrocyte sub‐state defined interferon‐responsive genes like Igtp, Ifit3, Mx1 , others, (IRRAs) . To further this...
Background: Fibromyalgia occurs in 2% to 8% of the general population. One triggers may be Lyme disease. Methods: Patients with culture-confirmed disease who originally presented erythema migrans have been evaluated annually a prospective study determine their long-term outcome. In 2011-2013, subjects were for fibromyalgia by interview and tender point examination. Results: 100 assessed, 52% whom male; mean age was 64.9 years (median 64 years, range 42-86 years). The duration follow-up 15.4...
Gun violence is an epidemic that affects hundreds of thousands Americans each year. Despite gun being disproportionately more lethal than other leading causes trauma, there a dearth research carried out on its root and prevention strategies. For the past 20 years, lobbying politics have interfered with forward progress research. Physicians history producing actionable public-health change ethical obligation to fight for will benefit their patients.