A5079827750- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- COVID-19 Clinical Research Studies
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- SARS-CoV-2 and COVID-19 Research
- Ocular Surface and Contact Lens
- Intensive Care Unit Cognitive Disorders
- Ophthalmology and Eye Disorders
- Ophthalmology and Visual Impairment Studies
- Blood Pressure and Hypertension Studies
- Drug-Induced Ocular Toxicity
- Long-Term Effects of COVID-19
- Ocular Oncology and Treatments
- Retinal Development and Disorders
- Cerebral Venous Sinus Thrombosis
- Systemic Lupus Erythematosus Research
- Sarcoidosis and Beryllium Toxicity Research
- Vector-Borne Animal Diseases
- Respiratory Support and Mechanisms
- Dermatologic Treatments and Research
- Plant Pathogenic Bacteria Studies
James Paget University Hospital
2015-2025
University of East Anglia
2016-2025
James Paget University Hospitals NHS Foundation Trust
2017-2025
University of South Alabama
2019-2024
The Recovery Center
2022
National Health and Medical Research Council
2021
Middle Tennessee State University
2018
University College London
1997-2017
The Royal Free Hospital
1997-2016
St Thomas' Hospital
2006-2016
<h3>Objective:</h3> To identify and follow a series of 52 patients with optic neuropathy related to sarcoidosis. <h3>Methods:</h3> Prospective observational cohort study. <h3>Results:</h3> The disorder was more common in women affected wide age range. It proportionately African Caribbean ethnic groups. Two clinical subtypes were identified: the subacute resembling neuritis; slowly progressive arose remaining 17%. Sixteen (31%) bilateral. Concurrent intraocular inflammation seen 36%. Pain...
Photobiomodulation (PBM) represents a potential treatment for non-exudative age-related macular degeneration (AMD). PBM uses wavelengths of light to target components the mitochondrial respiratory chain improve cellular bioenergetic outputs. The aim this study was further investigate effects on clinical, quality life (QoL) and anatomical outcomes in subjects with intermediate stage AMD. multicenter LIGHTSITE II randomized clinical trial evaluating safety efficacy LumiThera Valeda® Light...
<b>Purpose:</b> Clinical outcomes for phacoemulsification surgery are still compared with the almost 10-year-old benchmark of 1997–98 National Cataract Surgery Survey (NCSS) published in this journal. Extraneous to peer-reviewed research literature, more recent databases suggest much better results may be being obtained. This offered rare opportunity perform an audit as investigating if was indeed case and a new is needed, additional standard rigorous study peer review by independent senior...
Purpose: To determine the incidence of blindness secondary to idiopathic intracranial hypertension (IIH) in United Kingdom. Methods: New cases occurring IIH were identified prospectively through British Ophthalmological Surveillance Unit (BOSU) from October 2005 November 2006. Only and those meeting World Health Organisation`s definition included. Cases that already blind or had been registered before study period excluded. Results: There 24 new registerable reported during 12 month period....
Purpose To assess the caregiver burden and factors determining in patients receiving ranibizumab therapy for neovascular AMD (nAMD). Methods This is a cross-sectional questionnaire survey of 250 matched patient dyads across three large ophthalmic treatment centres United Kingdom. The primary outcome was subjective measured using reaction assessment scale (CRA). Objective determined by tasks level care provided. that may predict such as patient’s visual acuity better eye vision related...
Visual Acuity (VA) and structural biomarker assessment before at 24-months after early detection routine treatment of second eye involvement with neovascular age-related macular degeneration (nAMD) additional comparison the first affected. Prospective, 22-centre observational study participants unilateral nAMD in Early Detection Neovascular AMD (EDNA) study, co-enrolled into Observing fibrosis, atrophy subretinal highly reflective material, intervention anti-VEGF (FASBAT) for an 2-year...
Importance Most neovascular age-related macular degeneration (nAMD) treatments involve long-term follow-up of disease activity. Home-monitoring would reduce the burden on patients and their caregivers release clinic capacity. Objective To evaluate 3 vision home-monitoring tests for to use detect active nAMD compared with diagnosing at hospital during after-treatment monitoring phase. Design, Setting, Participants This was a diagnostic test accuracy study wherein reference standard detection...
Neovascular age-related macular degeneration (nAMD) is a leading cause of blindness. The first-line therapy anti-vascular endothelial growth factor (anti-VEGF) agents delivered by intravitreal injection. Ionising radiation mitigates key pathogenic processes underlying nAMD, and therefore has therapeutic potential. STAR aimed to assess whether stereotactic radiotherapy (SRT) reduces the number anti-VEGF injections required, without sacrificing visual acuity.
Abstract Aims This study aims to quantify the diagnostic test-accuracy of three visual function self-monitoring tests for detection active disease in patients with neovascular age-related macular degeneration (nAMD) when compared usual care. An integrated qualitative will investigate acceptability these home-based testing strategies. Methods All consenting participants are provided an equipment pack containing iPod touch two vision test applications installed and a paper journal reading...
Background/Aims Prospective data on switching anti-vascular endothelial growth factors in patients with neovascular age-related macular degeneration (nAMD) who have previously shown no/partial response are limited. This prospective study assessed the effect of from aflibercept to ranibizumab anatomical and functional outcomes persistent/recurrent disease activity. Methods SAFARI ( NCT02161575 ) was a 6-month, prospective, single-arm conducted UK Germany. Patients, meeting strict eligibility...
To evaluate the diagnostic accuracy of routinely used tests visual function and retinal morphology compared with fundus fluorescein angiography (FFA) to detect onset active macular neovascularization in unaffected fellow eyes patients unilateral neovascular age-related degeneration (nAMD). Prospective cohort study conducted 24 eye clinics United Kingdom over 3 years. Older adults (>50 years) recently diagnosed nAMD a (study) free nAMD. Self-reported vision, Amsler, clinic-measured acuity...
Neovascular age-related macular degeneration (nAMD) is a chronic, progressive condition and the commonest cause of visual disability in older adults. This study formed part diagnostic test accuracy to quantify ability three index home monitoring (HM) tests (one paper-based two digital tests) identify reactivation nAMD. The aim this qualitative research was investigate patients' or participants' views about acceptability explore adherence weekly HM. Semi-structured interviews were held with...
This article explores the factors contributing to injury severity resulting from rural intersection crashes in Alabama under different lighting conditions. Given occurrence of a crash, separate mixed logit models (with possible outcomes fatal, major, minor, and or no injury) were estimated for conditions: i. dark ii. lighted (including daylight). The identified variety statistically significant influencing severities. According these models, some variables found be only one model but not...
Objectives Remote monitoring of health has the potential to reduce burden patients face-to-face appointments and make healthcare more efficient. Apps are available for self-monitor vision at home, example, detect reactivation age-related macular degeneration (AMD). Describing challenges when implementing apps self-monitoring home was an objective MONARCH study evaluate two vision-monitoring on iPod Touch (Multibit MyVisionTrack). Design Diagnostic Test Accuracy study. Setting Six UK...