A5100352850- Hippo pathway signaling and YAP/TAZ
- Ion channel regulation and function
- Angiogenesis and VEGF in Cancer
- Adenosine and Purinergic Signaling
- Thermography and Photoacoustic Techniques
- Alzheimer's disease research and treatments
- Phytochemicals and Antioxidant Activities
- Fuel Cells and Related Materials
- Trace Elements in Health
- Kruppel-like factors research
- Prion Diseases and Protein Misfolding
- Ion Channels and Receptors
- Cancer-related gene regulation
- Proteoglycans and glycosaminoglycans research
- Lipid Membrane Structure and Behavior
- Optical Systems and Laser Technology
- Autoimmune and Inflammatory Disorders Research
- Phytochemicals and Medicinal Plants
- Image Processing Techniques and Applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Advanced Measurement and Metrology Techniques
- Force Microscopy Techniques and Applications
- RNA and protein synthesis mechanisms
- Autophagy in Disease and Therapy
- Synthesis of Organic Compounds
Anhui Polytechnic University
2024-2025
Nankai University
2004-2023
Northeastern University
2023
Liaoning Normal University
2023
Changhai Hospital
2020
Second Military Medical University
2020
Qilu Hospital of Shandong University
2019
Institute of Biophysics
2011
Chinese Academy of Sciences
2011
Increasing evidence demonstrates that ubiquitin specific protease 39 (USP39) plays an oncogenic role in various human tumors. Here, using expression analysis of the publicly available Oncomine database, clinical glioma patient samples, and cells, we found USP39 was overexpressed gliomas. Knockdown cells demonstrated protein promoted cell growth, invasion migration vitro a tumor model nude mice. To identify mediators growth-promoting properties, used luciferase reporter constructs under...
Abstract The Synaptotagmin-like Mitochondrial-lipid-binding Protein (SMP) domain is a newly identified lipid transfer module present in proteins that regulate homeostasis at membrane contact sites (MCSs). However, how the SMP associates with to extract and unload lipids unclear. Here, we performed vitro DNA brick-assisted assays silico molecular dynamics simulations investigate basis of association by extended synaptotagmin (E-Syt), which tethers tubular endoplasmic reticulum (ER) plasma...
Background: Our previous studies reported that lymphoid enhancer-binding factor 1 (LEF1) was upregulated in esophageal squamous cell carcinoma (ESCC) and the positive expression of LEF1 correlated with aberrant clinicopathological characteristics ESCC patients. However, upstream mechanism regulating is not clear fully. In this study, we explored role miR-34a-5p possible regulatory mechanism. Methods: applied western blotting, quantitative real-time polymerase chain reaction (qRT-PCR),...
Context: Previous in vitro studies have demonstrated that emodin (1,3,8-trihydroxy-6-methyl-anthraquinone), an anthraquinone derivative from the rhizome of Rheum palmatum L., can inhibit activation P2X7 receptors (P2X7R) as a potential antagonist. However, effects on P2X7R-related inflammatory processes remain unclear.Objective: This study aimed to investigate different inflammation responses macrophages induced by ATP, natural ligand P2X7R.Materials and methods: Rat peritoneal were treated...
Peptides and proteins possess an inherent propensity to self-assemble into generic fibrillar nanostructures known as amyloid fibrils, some of which are involved in medical conditions such Alzheimer disease. In certain cases, structures can self-propagate living systems prions transmit characteristic traits the host organism. The mechanisms that allow species but not others function fully understood. Much progress understanding prion phenomenon has been achieved through study yeast this...
SCTS inhibits neovascularization by blocking the VEGF/VEGFR2 signal pathway and exerts anti-tumor effects.
ABSTRACT The Sarcolipin (SLN) is a single trans‐membrane protein that can self‐assembly to dimer and oligomer for playing importantphysiological function. In this work, we addressed the dimerization of wild type SLN (wSLN) its mutants (mSLNs) – I17A I20A, using both coarse‐grained (CG) atomistic (AT) molecular dynamics (MD) simulations. Our results demonstrated wSLN homodimer assembled as left‐handed helical complex, while mSLNs heterodimers right‐handed complexes. Analysis residue‐residue...
A series of hesperetin derivatives were synthesized by Williamson etherification, Steglich esterification and ring-opening modifying the 7 hydroxyl group, 3' group C ring hesperetin. All compounds confirmed IR, 1H NMR, 13C NMR HR-MS. The antioxidant activity was tested ABTS method. Hp-1, Hp-2(b,d), Hp-3, Hp-5, Hp-6(a-d) Hp-7(a-c) had effects, Hp-7a strongest effect, which better than positive control quercetin, TEAC value 4.62 mM. Hp-2b, Hp-7b Hp-7c inhibitory effects on tyrosinase, superior...
A method of measuring the refractive indices minute samples by analyzing capillary interferometry is introduced. With interference theory light, intensity distribution an fringe pattern formed a cylindrical tube obtained, and influence some parameters on fringes are discussed. The measurement accuracy its relative problems analyzed.