A5055234777- bioluminescence and chemiluminescence research
- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Radioactive element chemistry and processing
- Electron Spin Resonance Studies
- Advanced Fluorescence Microscopy Techniques
- Photoreceptor and optogenetics research
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- Neuroscience and Neural Engineering
- Virus-based gene therapy research
Michigan State University
2021-2023
Material Sciences (United States)
2021
Genetically encoded optical sensors and advancements in microscopy instrumentation techniques have revolutionized the scientific toolbox available for probing complex biological processes such as release of specific neurotransmitters. Most genetically currently used are based on fluorescence been highly successful tools single-cell imaging superficial brain regions. However, there remains a need to develop new reporting neuronal activity vivo within deeper structures without hardware lenses...
Abstract Chemical exchange saturation transfer (CEST) MRI has been identified as a novel alternative to classical diagnostic imaging. Over the last several decades, many studies have conducted determine possible CEST agents, such endogenously expressed compounds or proteins, that can be utilized produce contrast with minimally invasive procedures and reduced non‐existent levels of toxicity. In recent years there an increased interest in generation genetically engineered typically based on...
Abstract Genetically encoded optical sensors and advancements in microscopy instrumentation techniques have revolutionized the scientific toolbox available for probing complex biological processes such as release of specific neurotransmitters. Most genetically currently used are based on fluorescence been highly successful tools single-cell imaging superficial brain regions. However, there remains a need to develop new reporting neuronal activity vivo within deeper structures without...
CEST reporter genes could play a critical role in the optimization of novel biological therapeutics. However, existing amide proton based have poor specificity as protons gene same chemical shift from endogenous proteins. Here we report on new class proteins with contrast at 5-ppm, tyrosine hydroxyl ring protons.
Chemical Exchange Saturation Transfer (CEST) magnetic resonance imaging (MRI) has been identified as a novel alternative to classical diagnostic imaging. Over the last several decades, many studies have conducted determine possible CEST agents, such endogenously expressed compounds or proteins, that can be utilized produce contrast with minimally invasive procedures and reduced non-existent levels of toxicity. In recent years there an increased interest in generation genetically engineered...