A5035154596- Influenza Virus Research Studies
- Inhalation and Respiratory Drug Delivery
- Immune Response and Inflammation
- interferon and immune responses
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Advanced Drug Delivery Systems
- Antimicrobial Peptides and Activities
- Malaria Research and Control
- Gut microbiota and health
- Computational Drug Discovery Methods
- Extracellular vesicles in disease
- Tryptophan and brain disorders
- Metabolomics and Mass Spectrometry Studies
- Mosquito-borne diseases and control
- Global Health Care Issues
- Clostridium difficile and Clostridium perfringens research
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Essential Oils and Antimicrobial Activity
- NF-κB Signaling Pathways
- Bioactive natural compounds
- Pharmacological Effects of Natural Compounds
- SARS-CoV-2 and COVID-19 Research
Jilin University
2019-2024
Huzhou University
2023
Jilin Medical University
2020
Abstract Background Gut microbiota (GM) of patients with liver cancer is disordered, and syet no study reported the GM distribution cirrhosis‐induced HCC (LC‐HCC) nonliver (NLC‐HCC). In this study, we aimed to characterize gut dysbiosis LC‐HCC NLC‐HCC elucidate role in pathogenesis HCC. Methods A consecutive series fecal samples hepatitis (24 patients), cirrhosis (75 patients: 35 infected by HBV, 25 HCV, 15 alcoholic disease), healthy controls (20 patients) were obtained sequenced on...
Abstract Background Severe, steroid-resistant asthma (SSRA) is a serious clinical problem in management. Affected patients have severe symptoms, worsened quality of life, and do not respond to steroid, mainstay steroid treatment asthma. Thus, effective therapies are urgently needed. Exosomes derived from mesenchymal stem cell (MSC-Exo) has become attractive candidates for the lung inflammatory diseases through its immunomodulatory effects. In this study, we explored therapeutic effects...
Abstract Neutrophilic asthma, as corticosteroid resistant is clinically more severe than eosinophilic asthma. Therefore, the treatment of neutrophilic asthma has been a challenging. Reactive oxygen species (ROS) play key role in However, direct use antioxidant enzymes, such catalase (CAT), challenging due to poor stability, short plasma half‐life, and lack effective drug delivery systems pulmonary systems. In this work, novel kind nanogels for delivering CAT (CAT‐NGs) synthesized,...
Purpose: Inhaled corticosteroids, including budesonide (BUD), are widely employed for the treatment of asthma. However, frequent use corticosteroids is associated with numerous adverse effects and poses challenges to ongoing drug therapy patient adherence. Budesonide liposomal nanoparticles (BUD-LNPs) were developed improve bioavailability thereby effectiveness asthma treatment. Methods: BUD-LNPs prepared via thin-film hydration, characterizations, stability, in vitro release studied. In...
Columbianadin (CBN) is one of the main bioactive constituents isolated from root Angelica pubescens. Although anti-inflammatory activity CBN has been reported, underpinning mechanism this remains unclear. In study, we investigated effect on lipopolysaccharide (LPS)-stimulated THP-1 cells and explored possible underlying molecular mechanisms. The results showed that suppressed LPS-mediated inflammatory response mainly through inactivation NOD1 NF- κ B p65 signaling pathways. Knockdown reduced...
Influenza A virus (IAV) infection leads to severe inflammation, and while epithelial-driven inflammatory responses occur via activation of NF-κB, the factors that modulate particularly negative regulators are less well-defined. In this study we show A20 is a crucial molecular switch dampens IAV-induced responses. Chronic exposure low-dose LPS environment can restrict excessive inflammation. The mechanisms provides suppress inflammation remain elusive. Here, our evidences chronic suppressed...
Abstract Background Integrating medical resources is one of the explorations mechanism reform to meet needs whole-cycle health management and an important initiative in current round China's healthcare system reform. 2015 saw construction county communities promote balanced layout resources, which opened a new exploration integrated service China. 2017 promotion pilot compact Zhejiang Province, Objective From perspective alleviating financial burden on those need services, characteristics...