A5091520661- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Calcium signaling and nucleotide metabolism
- Head and Neck Cancer Studies
- Cardiac Fibrosis and Remodeling
- Radiomics and Machine Learning in Medical Imaging
- Adipose Tissue and Metabolism
- RNA modifications and cancer
First Affiliated Hospital of Zhengzhou University
2023-2024
University of Chinese Academy of Sciences
2016
Abstract Kv2.1 as a voltage-gated potassium (Kv) channel subunit has pivotal role in the regulation of glucose-stimulated insulin secretion (GSIS) and pancreatic β -cell apoptosis, is believed to be promising target for anti-diabetic drug discovery, although mechanism underlying Kv2.1-mediated apoptosis obscure. Here, small molecular compound, ethyl 5-(3-ethoxy-4-methoxyphenyl)-2-(4-hydroxy-3-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2–a]pyrimidine-6-carboxylate...
Endothelial‐to‐mesenchymal transition (EndMT) is the process by which endothelial cells lose their properties and acquire mesenchymal characteristics. Dual‐specific protein phosphatase 22 (DUSP22) inactivates various kinases transcription factors dephosphorylating serine/threonine residues: hence, it plays a key role in many diseases. The aim of this study was to explore functional DUSP22 EndMT. In transforming growth factor‐ β ‐induced EndMT model human umbilical vein (HUVECs), we observed...
目的： 比较原位杂交检测人乳头瘤病毒（HPV）E6/E7 mRNA与免疫组织化学（IHC）检测p16在口咽部鳞状细胞癌（OPSCC）中的表达异同并分析HPV阳性OPSCC的临床病理特征。 方法： 收集郑州大学第一附属医院病理科OPSCC样本62例，采用HPV E6/E7 mRNA（原位杂交）检测肿瘤组织的HPV感染表达状态，同时进行p16 IHC检测；收集入组病例的临床病例信息，分析不同检测结果与其临床病理参数的相关性。 结果： 62例OPSCC标本中，男性43例，女性19例，平均年龄58岁。病理形态学特点以黏膜下浸润性肿瘤为主，HPV mRNA阳性肿瘤形态学上多以低分化和基底样特征为主，大多数肿瘤缺乏角化，扁桃体是其好发部位。在对两种不同HPV检测方法与OPSCC病理特征的比较分析中发现，p16阳性与p16阴性OPSCC两组在性别、烟史、肿瘤原发部位、肿瘤分期、淋巴结转移及治疗方式上差异均无统计学意义。当以HPV mRNA检测结果为准进行分组时，HPV mRNA阳性和HPV mRNA阴性OPSCC两组在原发部位和治疗方式上差异有统计学意义。 结论：...