A5081216750- Science, Research, and Medicine
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Neuropeptides and Animal Physiology
- Biotechnology and Related Fields
- RNA Interference and Gene Delivery
- Biomedical Ethics and Regulation
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Alzheimer's disease research and treatments
- Pancreatic function and diabetes
- SARS-CoV-2 and COVID-19 Research
- Psychedelics and Drug Studies
- Epigenetics and DNA Methylation
- Pharmacological Receptor Mechanisms and Effects
- Histone Deacetylase Inhibitors Research
- Mitochondrial Function and Pathology
- Protein Kinase Regulation and GTPase Signaling
- MicroRNA in disease regulation
- Protein Degradation and Inhibitors
- Inflammatory mediators and NSAID effects
- Pharmacogenetics and Drug Metabolism
- Metabolism, Diabetes, and Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
Hospice UK
2025
Public Service Electric and Gas (United States)
2021-2024
Canterbury College
2024
St Christopher's Hospice
2016-2023
Multidisciplinary Association for Psychedelic Studies
2023
University of California, San Francisco
2023
Health Economics and Outcomes Research (United Kingdom)
2023
Oxford Health NHS Foundation Trust
2021
University of Oxford
2021
Buckinghamshire Healthcare NHS Trust
2021
Abstract Post-traumatic stress disorder (PTSD) presents a major public health problem for which currently available treatments are modestly effective. We report the findings of randomized, double-blind, placebo-controlled, multi-site phase 3 clinical trial (NCT03537014) to test efficacy and safety 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy treatment patients with severe PTSD, including those common comorbidities such as dissociation, depression, history alcohol substance use...
This multi-site, randomized, double-blind, confirmatory phase 3 study evaluated the efficacy and safety of 3,4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) versus placebo with identical in participants moderate to severe post-traumatic stress disorder (PTSD). Changes Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) total severity score (primary endpoint) Sheehan Disability (SDS) functional impairment (key secondary were assessed by blinded independent assessors. Participants...
Post-traumatic stress disorder (PTSD) presents a major public health problem for which currently available treatments are modestly effective. We report the findings of randomized, double-blind, placebo-controlled, multi-site phase 3 clinical trial (NCT03537014) to test efficacy and safety 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy treatment patients with severe PTSD, including those common comorbidities such as dissociation, depression, history alcohol substance use disorders,...
Introduction There is a resurgence of interest in the therapeutic potential psychedelic substances such as 3,4-methylenedioxymethamphetamine (MDMA). Primary findings from our randomized, double-blind, placebo-controlled, multi-site Phase 3 clinical trial participants with severe PTSD (NCT03537014) showed that MDMA-assisted therapy induced significant attenuation Clinician-Administered Scale for DSM-5 compared to Therapy placebo. Deficits emotional coping skills and altered self-capacities...
RGS (regulators of Gprotein signaling) proteins are GTPase-activating for the Gα subunits heterotrimeric G and act to regulate signaling by rapidly cycling protein. may integrate receptors pathways physical or kinetic scaffolding mechanisms. To determine whether this results in enhancement and/or selectivity agonist signaling, we have prepared C6 cells stably expressing μ-opioid receptor either pertussis toxin-insensitive RGS- Gα<sub>o</sub>. We compared activation protein, inhibition...
Emerging clinical trial data suggest that individual immunomodulatory drugs can dampen the hyperactive immune system in severe COVID-19, but polytherapy is way forward.
Previous research has demonstrated that epigenetic changes in specific hypothalamic-pituitary-adrenal (HPA) genes may predict successful psychotherapy post-traumatic stress disorder (PTSD). A recent Phase 3 clinical trial reported high efficacy of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for treating patients with severe PTSD compared to a placebo group (NCT03537014). This raises important questions regarding potential mechanisms MDMA-assisted therapy. In the present study,...
An elevation in intracellular calcium concentration ([Ca(2+)](i)) acts to trigger a range of cellular events including neurotransmitter release, muscle contraction, and oocyte fertilization. The pattern [Ca(2+)](i) response that is dependent on the agonist cell type.
The aim of this study was to investigate the relative density μ-, κ-, and δ-opioid receptors (MOR, KOR, DOR) guanosine 5′-<i>O</i>-(3-[<sup>35</sup>S]thio)triphosphate ([<sup>35</sup>S]GTPγS) binding stimulated by full agonists in cortical thalamic membranes monkeys. parameters [<i>B</i><sub>max</sub> (femtomoles per milligram)/<i>K</i><sub>d</sub> (nanomolar)] were as follows: [<sup>3</sup>H][d-Ala<sup>2</sup>,<i>N</i>-Me-Phe<sup>4</sup>,Gly<sup>5</sup>-ol]-enkephalin (DAMGO) (MOR; 80/0.7),...