A5078452831- Neurotransmitter Receptor Influence on Behavior
- Psychedelics and Drug Studies
- Cannabis and Cannabinoid Research
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Substance Abuse Treatment and Outcomes
- Neural and Behavioral Psychology Studies
- Chemical synthesis and alkaloids
- Pain Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Religious Freedom and Discrimination
- Sexuality, Behavior, and Technology
- American Constitutional Law and Politics
- Gender, Feminism, and Media
- Reproductive Biology and Fertility
- Medical Coding and Health Information
- Pain Management and Placebo Effect
- Sperm and Testicular Function
- Neuroscience and Neuropharmacology Research
- Literature: history, themes, analysis
- Pregnancy and preeclampsia studies
- Bacillus and Francisella bacterial research
- Themes in Literature Analysis
- Maternal Mental Health During Pregnancy and Postpartum
- Gambling Behavior and Treatments
University of California, San Francisco
2015-2025
University of California, Berkeley
2005-2025
Multidisciplinary Association for Psychedelic Studies
2023-2025
San Francisco VA Medical Center
2016-2025
Suffolk University
2025
Kaiser Permanente
2025
San Francisco VA Health Care System
2020-2025
University of California System
2025
Children's Center
2023-2024
The University of Texas MD Anderson Cancer Center
2013-2023
Abstract Post-traumatic stress disorder (PTSD) presents a major public health problem for which currently available treatments are modestly effective. We report the findings of randomized, double-blind, placebo-controlled, multi-site phase 3 clinical trial (NCT03537014) to test efficacy and safety 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy treatment patients with severe PTSD, including those common comorbidities such as dissociation, depression, history alcohol substance use...
The tendency to choose lesser immediate benefits over greater long-term characterizes alcoholism and other addictive disorders. However, despite its medical socioeconomic importance, little is known about neurobiological mechanisms. Brain regions that are activated when deciding between or delayed rewards have been identified (McClure et al., 2004, 2007), as areas in which responses reward stimuli predict a paper-and-pencil measure of temporal discounting (Hariri 2006). These studies assume...
Excessive consumption of alcohol is among the leading causes preventable death worldwide. Although ethanol modulates a variety molecular targets, including several neurotransmitter receptors, neural mechanisms that underlie its rewarding actions and lead to excessive are unknown. Studies in animals suggest release endogenous opioids by promotes further consumption. To examine this issue humans determine where brain act promote consumption, we measured displacement radiolabeled μ opioid...
BackgroundPsilocybin therapy has shown promise as a rapid-acting treatment for depression, anxiety, and demoralization in patients with serious medical illness (e.g., cancer) when paired individual psychotherapy. This study assessed the safety feasibility of psilocybin-assisted group older long-term AIDS survivor (OLTAS) men, population high degree traumatic loss.MethodsSelf-identified gay men OLTAS moderate-to-severe (Demoralization Scale-II ≥8) were recruited from community major US city...
This multi-site, randomized, double-blind, confirmatory phase 3 study evaluated the efficacy and safety of 3,4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) versus placebo with identical in participants moderate to severe post-traumatic stress disorder (PTSD). Changes Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) total severity score (primary endpoint) Sheehan Disability (SDS) functional impairment (key secondary were assessed by blinded independent assessors. Participants...
Post-traumatic stress disorder (PTSD) presents a major public health problem for which currently available treatments are modestly effective. We report the findings of randomized, double-blind, placebo-controlled, multi-site phase 3 clinical trial (NCT03537014) to test efficacy and safety 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy treatment patients with severe PTSD, including those common comorbidities such as dissociation, depression, history alcohol substance use disorders,...
Abstract: Background: Impaired decision-making is one diagnostic characteristic of alcoholism. Quantifying with rapid and robust laboratory-based measures thus desirable for the testing novel treatments Previous research has demonstrated utility delay discounting (DD) tasks quantifying differences in substance abusers normal controls. In DD paradigms subjects choose between a small, immediate reward larger, delayed reward. Methods: We used computerized task to demonstrate that abstinent...
Behavioural and pharmacological effects of Δ9‐tetrahydrocannabinol (THC) nicotine are well known. However, the possible interactions between these two drugs abuse remain unclear in spite current association cannabis tobacco humans. The present study was designed to analyse consequences administration on THC‐induced acute behavioural biochemical responses, tolerance physical dependence. Nicotine strongly facilitated hypothermia, antinociception hypolocomotion induced by THC. Furthermore,...
Summary: Polycystic ovaries (PCO) diagnosed by ultrasound have been commonly reported amongst healthy women. The study aimed to determine the prevalence of PCO in a population women from community, and relate it clinical endocrinological data. Twelve hundred chosen randomly electoral rolls were invited take part study. Two fifty five (21%) who met eligibility criteria agreed participate 183 (16%) finally completed Seventy two did not attend. An scan blood tests taken on day 5–9 their...
Broad action potentials (APs) and dopamine (DA) D 2 receptor (D R)-mediated inhibition are widely used to identify midbrain DA neurons. However, when these measures taken alone they do not predict content in ventral tegmental area (VTA) In fact, some VTA neuronal properties correlate better with projection target than neurotransmitter content. Here we report that amygdala (AMYG)-projecting neurons have brief APs lack R agonist (quinpirole; 1 μ m ) autoinhibition. hyperpolarized by both the...
Emerging evidence suggests that the α4β2 form of nicotinic acetylcholine receptor (nAChR) modulates rewarding effects alcohol. The nAChR subunit partial agonist varenicline (Chantix™), which is approved by Food and Drug Administration for smoking cessation, also decreases ethanol consumption in rodents (Steensland et al., Proc Natl Acad Sci U S A 104:12518–12523, 2007) human laboratory open-label studies (Fucito Psychopharmacology (Berl) 215:655–663, 2011; McKee Biol Psychiatry 66:185–190...
Value-based decisions optimize behavioral outcomes. Because delayed rewards are discounted, an increased tendency to choose smaller, immediate can lead suboptimal choice. Steep discounting of (impulsivity) characterizes subjects with frontal lobe damage and disorders including substance abuse. Correspondingly, animal studies indirect evidence in humans suggest that lower dopamine the cortex contributes steeper by impairing corticostriatal function. To test this hypothesis directly, we...
Research into the therapeutic potential of α-calcitonin gene-related peptide (α-CGRP) has been limited because its nature and short half-life. Here, we evaluate whether a novel potent long-lasting (t½ ≥7 hours) acylated α-CGRP analogue (αAnalogue) could alleviate reverse cardiovascular disease in 2 distinct murine models hypertension heart failure vivo.The ability αAnalogue to act selectively via CGRP pathway was shown skin by using receptor antagonist. The effect on angiotensin II-induced...
Post-traumatic stress disorder (PTSD) is commonly associated with alcohol and substance use disorders (ASUD). A randomized, placebo-controlled, phase 3 trial demonstrated the safety efficacy of MDMA-assisted therapy (MDMA-AT) for treatment severe PTSD. This analysis explores patterns in patients receiving MDMA-AT compared to placebo plus (Placebo+Therapy). Adult participants PTSD (n = 90) were randomized three blinded trauma-focused sessions either or Placebo+Therapy. Eligible met DSM-5...
Objectives: A pharmacotherapy that both improves social abilities and promotes abstinence may be particularly helpful for the treatment of alcohol use disorder. Recent clinical preclinical evidence suggests oxytocin has prosocial antiaddiction effects. We performed a pilot, laboratory-based, trial in subjects with abuse (as per Diagnostic Statistical Manual Mental Disorders, 4th Edition criteria) to evaluate therapeutic potential assess tolerability. Methods: Social perceptual ability,...
Abstract A major challenge in stem cell differentiation is the availability of bioassays to prove types generated vitro are equivalent cells vivo. In mouse, primordial germ cell-like (PGCLCs) from pluripotent was validated by transplantation, leading generation spermatogenesis and birth offspring. Here we report use xenotransplantation (monkey mouse) homologous transplantation monkey) validate our protocol for differentiating male rhesus (r) macaque PGCLCs (rPGCLCs) induced (riPSCs)....
Severe posttraumatic stress disorder (PTSD) is a prevalent and debilitating condition in the United States. globally. Using pooled efficacy data from six phase 2 trials, therapy using 3,4-methylenedioxymethamphetamine (MDMA) appeared cost-saving payer's perspective. This study updates cost-effectiveness analysis of this novel new 3 trial, including incremental more intensive regimen compared with shorter regimen.We adapted previously-published Markov model to portray costs health benefits...
Alcoholism is a complex and debilitating syndrome affecting ∼140 million people worldwide. However, not everyone who consumes ethanol develops abuse, raising the possibility that some individuals have protective mechanism inhibits elevated alcohol consumption. We tested hypothesis δ-opioid receptor (DOR) plays such role. Here we show DOR activity in ventral tegmental area (VTA) robustly decreases consumption rats these effects depend on baseline Intra-VTA microinjection of agonist DPDPE...
Bisexuality is an often invisible identity. Heterosexual and homosexual communities contribute to bisexual erasure, acting in concert protect a binary system that complicated disrupted by the possibility presence of bisexuality. This article approaches erasure from three different perspectives: historical context, contemporary media literary representations. Contemporary cultural norms "pop science" demonstrate acceptance two types partner choice—heterosexual homosexual—whereas person made...