A5077162761- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Circular RNAs in diseases
- Pediatric Hepatobiliary Diseases and Treatments
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Pleural and Pulmonary Diseases
- Cancer Mechanisms and Therapy
- Neuroendocrine Tumor Research Advances
- Extracellular vesicles in disease
- Ultrasound and Hyperthermia Applications
- Vascular Malformations and Hemangiomas
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Cardiac tumors and thrombi
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Occupational and environmental lung diseases
Eastern Hepatobiliary Surgery Hospital
2009-2024
Second Military Medical University
2010-2024
The University of Tokyo
2022-2023
State Council of the People's Republic of China
2019
Abstract Hepatocellular carcinoma (HCC) is a heterogeneous tumor with an increased incidence worldwide accompanied by high mortality and dismal prognosis. Emerging evidence indicates that mesenchymal stem cells (MSCs)-derived exosomes possess protective effects against various human diseases transporting microRNAs (miRNAs or miRs). We aimed to explore the role of exosomal miR-15a derived from MSCs its related mechanisms in HCC. Exosomes were isolated transduced co-incubated Hep3B Huh7 cells....
Numerous studies have suggested that dysregulated long noncoding RNAs (lncRNAs) contributed to the development and progression of many cancers. lncRNA OIP5 antisense RNA 1 (OIP5-AS1) has been reported be increased in several However, roles OIP5-AS1 liver hepatocellular carcinoma (LIHC) remain investigated. In this study, we demonstrated was upregulated LIHC tissue specimens its overexpression associated with poor survival patients LIHC. Furthermore, loss-of function experiments indicated...
The roles of γδ T cells in liver cancer, especially the potential function immunotherapy due to their direct cytotoxic effects on tumor and secretion important cytokines chemokines, have aroused research interest. This review briefly describes basic characteristics cells, focusing diverse cancer. In particular, different subtypes or even opposite We provide a detailed description immune regulatory network cancer from two aspects: components nonimmune components. interactions between various...
To systematically evaluate the whole-transcriptome sequencing data of cholangiocarcinoma (CHOL) to gain more insights into transcriptomic landscape and molecular mechanism this cancer, we performed based on tumorous (C) their corresponding non-tumorous adjacent tumors (CP) from eight CHOL patients. Subsequently, differential expression analysis was C CP groups, followed by functional interaction prediction investigate gene-regulatory circuits in CHOL. In addition, The Cancer Genome Atlas...
BACKGROUND Long non-coding RNAs (lncRNAs) have been implicated in various human cancer types. However, the underlying mechanisms involved hepatocellular carcinoma (HCC) progression remain poorly understood. MATERIAL AND METHODS In this study, lncRNA array was used to identify HCC related lncRNAs. RNA immunoprecipitation (RIP) followed mass spectrometry explore binding proteins. Western blot, quantitative PCR, tumor sphere formation, migration and viability assay were performed evaluate...
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a unique type of liver tumor that contains both hepatocellular carcinoma and cholangiocarcinoma components within single tumor. The fifth edition the World Health Organization classification provides definition diagnostic criteria for cHCC-CCA. However, heterogeneous histomorphology presentation resulting from variation proportion each component poses challenges clinical diagnosis treatment. A cHCC-CCA may be suggested by synchronous...
The aim of this study was to develop and validate a nomogram predict the overall survival incidental gallbladder cancer.A total 383 eligible patients with cancer diagnosed in Shanghai Eastern Hepatobiliary Surgery Hospital from 2011 2021 were retrospectively included. They randomly divided into training cohort (70%) validation (30%). Univariate multivariate analyses Akaike information criterion used identify variables independently associated survival. A Cox proportional hazards model...
Abstract Gallbladder carcinoma (GBC) is a lethal biliary tract malignant neoplasm. Patient-derived primary cancer cell lines (PDPCs) are appropriate models to explore biological characteristics and potential therapeutics; however, there lack of PDPCs in GBC. In this study, we aimed establish characterize the GBC PDPCs, further investigated intra-tumor heterogeneity (ITH). Multi-region sampling (3–9 regions) operable tumor tissue samples was used PDPCs. Short tandem repeat genotyping for...
The aim of this study was to investigate the prognostic value dicarbonyl/L-xylulose reductase (DCXR) in human hepatocellular carcinoma (HCC). Immunohistochemistry and tissue microarrays were used evaluate DCXR protein expression levels. Image-Pro Plus calculate integral optic density (IOD) each sample, which represented level DCXR. proteins found be significantly lower HCC tumor tissues (P < 0.0001) according immunohistochemical analysis levels 74 paired peritumoral non-cancer tissues....
The effect of cirrhosis on the characteristics intrahepatic cholangiocarcinoma (ICC) has not been fully elucidated. purpose this study was to investigate how affects clinicopathological and survival surgically treated ICC patients. A total 1,312 patients between January 2007 December 2011 at a single institution were retrospectively reviewed data compared cirrhotic non-cirrhotic Univariate multivariate analyses performed identify significant independent prognostic factors in cohort. 302...
Abstract Ultrasound plays an important role not only in preoperative diagnosis but also intraoperative guidance for liver surgery. Intraoperative ultrasound (IOUS) has become indispensable tool modern surgeons, especially minimally invasive surgeries, partially substituting the surgeon's hands. In fundamental mode, Doppler contrast enhancement, elastography, and real-time virtual sonography, IOUS can provide additional information regarding intrahepatic anatomy, tumor site characteristics,...
Hepatic epithelioid hemangioendothelioma (HEHE) is a rare hepatic vascular tumor with borderline biological behavior between hemangioma and hemangiosarcoma. It tends to be multiple or diffuse subcapsular lesions across the liver but has no characteristic clinical manifestations imaging findings. On computed tomography magnetic resonance imaging, these usually have hypodense appearance heterogeneous enhancement "halo sign" "lollipop may evident in some cases. HEHE diagnosed mainly based on...
Combined hepatocellular and cholangiocarcinoma (HCC-CC) is a unique primary epithelial tumor of the liver classified by World Health Organization (WHO) as containing elements both carcinoma (HCC) (CC).The clinical diagnosis established histopathology firm pathological from definitive evidence HCC CC differentiation.HCC-CC's features tend to resemble in regards venous infiltration like with respect lymph node metastasis.To date,the biological behavior HCC-CC remains ill-defined; however its...
Numerous studies have suggested that dysregulated long noncoding RNAs (lncRNAs) contributed to development and progression of many cancers. LncRNA OIP5 antisense RNA 1 (OIP5-AS1) has been reported be increased in several However, the roles OIP5-AS1 liver hepatocellular carcinoma (LIHC) remain investigated. In this study, we demonstrated was up-regulated LIHC tissue specimens its overexpression associated with poor survival patients LIHC. Furthermore, loss-of function experiments indicated...