A5020608496- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Protein purification and stability
- Cytokine Signaling Pathways and Interactions
- Virus-based gene therapy research
- Biosimilars and Bioanalytical Methods
- interferon and immune responses
Shanghai Research Institute of Chemical Industry
2024
Southern Medical University
2012
Nanfang Hospital
2012
Nasopharyngeal carcinoma (NPC) is a highly malignant and frequently metastasized tumor, the prognosis very poor when distant metastases occur. Recently, immunotherapy becoming promising therapeutic approach. Interferon-α (IFN-α) represents cytokines exhibiting longest record of use in clinical oncology. In this study, we examined antitumor effects IFN-α1b on NPC. The results showed that recombinant human (hIFN-α1b) suppressed cell growth, induced G1-phase cycle arrest vitro, increased...
B-cell lymphoma, clinically, comprises a heterogeneous group of malignancies that encompass various subtypes. CD20 is an optimal target for therapeutic antibodies in lymphoma immunotherapy since approximately 90% typically exhibit expression on their surface, while its presence limited normal tissues. In this study, we have developed series novel non-IgG-like T cell-dependent bispecific by constructing Fab-FabCH3, referred to as Tandem Antigen-binding Fragment 002 (TFAB002), which...