A5058221749- Renal cell carcinoma treatment
- RNA modifications and cancer
- MRI in cancer diagnosis
- Bladder and Urothelial Cancer Treatments
- Microplastics and Plastic Pollution
- Multiple and Secondary Primary Cancers
- Graphene and Nanomaterials Applications
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Renal and Vascular Pathologies
- Cytokine Signaling Pathways and Interactions
- Virus-based gene therapy research
- semigroups and automata theory
- Metabolism and Genetic Disorders
- Endoplasmic Reticulum Stress and Disease
- Alzheimer's disease research and treatments
- Fuzzy and Soft Set Theory
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Nanoparticles: synthesis and applications
- Radiomics and Machine Learning in Medical Imaging
- Effects and risks of endocrine disrupting chemicals
- Curcumin's Biomedical Applications
- Autophagy in Disease and Therapy
Fuyang Normal University
2024-2025
Yunnan Agricultural University
2025
Dalian Medical University
2023-2024
Second Affiliated Hospital of Dalian Medical University
2023-2024
Sun Yat-sen University
2023
Sun Yat-sen University Cancer Center
2023
The combined pollution of microplastics (MPs) and sulfamethoxazole (SMZ) often occurs in aquatic ecosystems, posing a serious threat to animal human health. However, little is known about the liver damage caused by single or co-exposure MPs SMZ, its specific mechanisms are still poorly understood. In this study, we investigated effects 20 μm 80 nm SMZ both larval adult zebrafish models. Firstly, observed significant decrease number hepatocytes worsened following MPs. Additionally,...
Elemene is widely recognized as an effective anti-cancer compound and routinely administered in Chinese clinical settings for the management of several solid tumors, including non-small cell lung cancer (NSCLC). However, its detailed molecular mechanism has not been adequately demonstrated. In this research, it was demonstrated that elemene effectively curtailed NSCLC growth patient-derived xenograft (PDX) model. Mechanistically, employing high-throughput screening techniques subsequent...
Objective Hepatic ischemia-reperfusion injury (HIRI) frequently occurs as a complication in liver surgeries, which significantly impacting patient outcomes. Sinensetin (SEN) is plant-derived polymethoxylated flavone with anti-inflammatory and anti-oxidative activities. However, the hepatoprotective effect of sinensetin HIRI pathogenesis have not been fully explored. Methods We constructed model mice, blood samples collected at 6 24 h after reperfusion to evaluate injury. also evaluated...
The synergistic mechanism between alkali activation and carbonation in fly ash recycled aggregate concrete (FRAC) remains a critical challenge for enhancing durability promoting solid waste utilization. This study systematically investigates the effects of CaO-based activator dosages (0%, 4%, 8%, 12%) on resistance, compressive strength, pore structure evolution. results demonstrated 8% CaO maximized strength (48.6 MPa, 10.76% higher than control group) minimized porosity (22.87% vs. 39.33%...
P23, historically known as a heat shock protein 90 (HSP90) co-chaperone, exerts some of its critical functions in an HSP90-independent manner, particularly when it translocates into the nucleus. The molecular nature underlying how this p23 function is achieved remains biological mystery. Here, we found that previously unidentified transcription factor COX-2, and nuclear localization predicts poor clinical outcomes. Intratumor succinate promotes succinylation at K7, K33, K79, which drives...
Nasopharyngeal carcinoma (NPC) is a highly malignant and frequently metastasized tumor, the prognosis very poor when distant metastases occur. Recently, immunotherapy becoming promising therapeutic approach. Interferon-α (IFN-α) represents cytokines exhibiting longest record of use in clinical oncology. In this study, we examined antitumor effects IFN-α1b on NPC. The results showed that recombinant human (hIFN-α1b) suppressed cell growth, induced G1-phase cycle arrest vitro, increased...
Objective: To report the long-term survival of renal cell carcinoma (RCC) patients treated with radical nephrectomy in Sun Yat-sen University Cancer Center. Methods: We retrospectively analyzed clinical, pathological and follow-up records 1 367 non-metastatic RCC from 1999 to 2020 this center. The primary endpoint study was overall rate. Survival curves were estimated using Kaplan-Meier method, group differences compared through Log-rank test. Univariate multivariate Cox analysis fit...
Abstract Metastasis serves as a malignant indicator and biological characteristic of pulmonary carcinoma. Epithelial-mesenchymal transition (EMT) plays pivotal role in facilitating tumor invasion metastasis, enhances the aggressiveness cells. Prostaglandin E synthase 3 (PTGES3) functions an HSP90 co-chaperone. Our previous study revealed its HSP90-independent transcription factor involved cancer-related inflammation. present aims to investigate impact mechanism p23 on lung cancer metastasis....
We show that all totally positive formal power series with integer coefficients and constant term $1$ are precisely the rank-generating functions of Schur-positive upho posets, thereby resolving main conjecture proposed by Gao, Guo, Seetharaman, Seidel. To achieve this, we construct a bijection between finitary colored posets atomic, left-cancellative, invertible-free monoids, which restricts to correspondence $\mathbb{N}$-graded left-cancellative homogeneous monoids. Furthermore, introduce...
Objectives: To analyze the long-term survival of patients with localized renal cell carcinoma after partical nephrectomy. Methods: The clinicopathological records and follow-up data 2 046 carcinoma, who were treated partial nephrectomy from August 2001 to February 2021 in Department Urology, Sun Yat-sen University Cancer Center, retrospectively analyzed. There 1 402 males 644 females, aged (M(IQR)) 51 (19) years (range: 6 86 years). primary end point this study was cancer-specific survival....
Objective: To establish a nomogram prognostic model for predicting the 5-, 10-, and 15-year overall survival (OS) of non-metastatic renal cell carcinoma patients managed with radical nephrectomy (RN), compare modelled results pure pathologic staging, Karakiewicz Mayo Clinic Stage, Size, Grade, Necrosis (SSIGN) score commonly used in foreign countries, stratify into different risk subgroups. Methods: A total 1 246 RN Sun Yat-sen University Cancer Center (SYSUCC) from 1999 to 2020 were...
Objectives: To analyze the factors relative to short-term preservation of ipsilateral renal function after partial nephrectomy. Methods: The clinical data 83 patients who were treated with nephrectomy from December 2014 2019 in Department Urology, Sun Yat-sen University Cancer Center retrospectively analyzed. There 54 males and 29 females, aging (M (IQR)) 49 (17) years (range: 27 74 years). ischemia time operation was 25 (18) minutes 10 67 minutes). Emission computed tomography scan CT...