A5102711784- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Signaling Pathways in Disease
- Eicosanoids and Hypertension Pharmacology
- Liver physiology and pathology
- Phytochemistry and Bioactive Compounds
- Genomics, phytochemicals, and oxidative stress
- Pharmacogenetics and Drug Metabolism
- Phytochemical compounds biological activities
- Mechanisms of cancer metastasis
- PI3K/AKT/mTOR signaling in cancer
- NF-κB Signaling Pathways
- Curcumin's Biomedical Applications
- Nuclear Receptors and Signaling
- Bioactive Natural Diterpenoids Research
- Mercury impact and mitigation studies
- Ginkgo biloba and Cashew Applications
- Circular RNAs in diseases
- Toxic Organic Pollutants Impact
- Ferroptosis and cancer prognosis
- Plant-based Medicinal Research
- Free Radicals and Antioxidants
- Natural Compounds in Disease Treatment
- Heat shock proteins research
Second Affiliated Hospital of Dalian Medical University
2022-2024
Dalian Medical University
2020-2024
Jiangxi University of Traditional Chinese Medicine
2020-2021
Longgang Central Hospital
2017
Second Xiangya Hospital of Central South University
2016
Central South University
2016
Abstract NEMO/IKKβ complex is a central regulator of NF-κB signaling pathway, its dissociation has been considered to be an attractive therapeutic target. Herein, using combined strategy molecular pharmacological phenotyping, proteomics and bioinformatics analysis, Shikonin (SHK) identified as potential inhibitor the IKKβ/NEMO complex. It destabilizes with IC 50 174 nM, thereby significantly impairing proliferation colorectal cancer cells by suppressing pathway in vitro vivo. In addition, we...
Elemene is widely recognized as an effective anti-cancer compound and routinely administered in Chinese clinical settings for the management of several solid tumors, including non-small cell lung cancer (NSCLC). However, its detailed molecular mechanism has not been adequately demonstrated. In this research, it was demonstrated that elemene effectively curtailed NSCLC growth patient-derived xenograft (PDX) model. Mechanistically, employing high-throughput screening techniques subsequent...
P23, historically known as a heat shock protein 90 (HSP90) co-chaperone, exerts some of its critical functions in an HSP90-independent manner, particularly when it translocates into the nucleus. The molecular nature underlying how this p23 function is achieved remains biological mystery. Here, we found that previously unidentified transcription factor COX-2, and nuclear localization predicts poor clinical outcomes. Intratumor succinate promotes succinylation at K7, K33, K79, which drives...
Human Cytochrome P450 2J2 (CYP2J2) as an important metabolic enzyme, plays a crucial role in metabolism of polyunsaturated fatty acids (PUFAs). Elevated levels CYP2J2 have been associated with various types cancer, and therefore it serves potential drug target. Herein, using high-throughput screening approach based on enzymic activity CYP2J2, we rapidly effectively identified novel natural inhibitor (Piperine, 9a) IC50 value 0.44 μM from 108 common herbal medicines. Next, series its...
Background: Neuroinflammation plays a crucial role in the pathogenesis and progression of various neurodegenerative diseases, including Alzheimer's disease. The Ginkgo biloba leaf extract (GBE) has been widely used to treat cerebral peripheral blood circulation disorders. However, its potential targets underlying mechanisms regarding neuroinflammation have not yet characterized. Aims: purpose this study was investigate validate anti-neuroinflammatory properties GBE against lipopolysaccharide...
Abstract Metastasis serves as a malignant indicator and biological characteristic of pulmonary carcinoma. Epithelial-mesenchymal transition (EMT) plays pivotal role in facilitating tumor invasion metastasis, enhances the aggressiveness cells. Prostaglandin E synthase 3 (PTGES3) functions an HSP90 co-chaperone. Our previous study revealed its HSP90-independent transcription factor involved cancer-related inflammation. present aims to investigate impact mechanism p23 on lung cancer metastasis....