A5062710998- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Retinal Diseases and Treatments
- Phytase and its Applications
- Plant Molecular Biology Research
- Biochemical effects in animals
- Environmental DNA in Biodiversity Studies
- Lysosomal Storage Disorders Research
- Plant Stress Responses and Tolerance
- Ubiquitin and proteasome pathways
- DNA Repair Mechanisms
- Microbial Community Ecology and Physiology
- Plant nutrient uptake and metabolism
- Alzheimer's disease research and treatments
- Identification and Quantification in Food
- Histone Deacetylase Inhibitors Research
- Connexins and lens biology
Duke University
2009-2024
Jiangxi Agricultural University
2024
Zhejiang University
2021
Sanya University
2021
Sun Yat-sen University
2019
Pratt Institute
2009
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, and neuroprotective or disease-modifying interventions remain elusive. High-throughput markers aimed at stratifying patients on basis of shared etiology are required to ensure success therapies in clinical trials. Mitochondrial dysfunction plays a prominent role pathogenesis PD. Previously, we found brain region–specific accumulation mitochondrial DNA (mtDNA) damage PD neuronal culture animal models, as well...
Abstract Pathogenic mutations in LRRK2 cause Parkinson’s disease (PD). The G2019S variant is the most common, which results abnormally high kinase activity. Compounds that target activity are currently being developed and tested clinical trials. We recently found causes mitochondrial DNA (mtDNA) damage treatment with multiple classes of inhibitors at concentrations associated dephosphorylation reversed mtDNA to healthy control levels. Because maintaining normal function heterozygous carriers...
Deep brain stimulation (DBS) of the subthalamic nucleus reduces severity parkinsonian motor symptoms, but therapeutic mechanisms are not understood. We hypothesize that clinically effective high frequency DBS suppresses disordered neuronal activity in globus pallidus internus (GPi), a primary output structure basal ganglia. In computational model ganglia thalamic circuit, periodic (>100 Hz) reduced incidence cell errors, from error rates seen case back to low normal-healthy case. contrast,...
In the study of environmental DNA (eDNA), rate water filtration and amount obtained are general interest to researchers. We compared PCTE filters with different pore sizes in enriching total fish eDNA from samples. also designed tested a new filter device PET pad (5 µm) superimposed on membrane (3 it pure filter. A comprehensive evaluation time, concentration, quantification, species detected showed that shortest average time was 8 μm size (2 min 9 s) longest 0.2 (32 6 s). The highest...
Advanced age is the largest risk factor for age-related macular degeneration (AMD). Sumoylation a reversible post-translational modification that conjugates small peptide, ubiquitin-like modifier (SUMO), to target protein. Dysregulation of sumoylation recently found be critically involved in several disorders. However, effects during retina senescence and aging remains elusive. This study aimed investigate function regulation pathway premature senescent retinal pigment epithelial (RPE)...
Watermelon (Citrullus lanatus) is a globally important Cucurbitaceae crop in which grafting commonly used to improve stress tolerance and enhance nutrient utilization. However, the mechanism underlying grafting-enhanced assimilation remains unclear. Here, we demonstrate possible involvement of novel miRNA, ClmiR86, phosphate-starvation via CALCINEURIN B-LIKE INTERACTING PROTEIN KINASE 5 (ClCIPK5) suppression watermelon. Transcript analyses revealed that induction ClmiR86 expression was...