A5087051923- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Disaster Response and Management
- Viral-associated cancers and disorders
- Viral Infections and Outbreaks Research
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 and healthcare impacts
- COVID-19 epidemiological studies
- interferon and immune responses
- Respiratory viral infections research
- Lysosomal Storage Disorders Research
- Phosphodiesterase function and regulation
- Parkinson's Disease Mechanisms and Treatments
- Synthesis and Catalytic Reactions
- Viral Infections and Vectors
- Plant Virus Research Studies
- Artificial Intelligence in Healthcare and Education
- Alzheimer's disease research and treatments
- Lymphoma Diagnosis and Treatment
- Influenza Virus Research Studies
- Vector-borne infectious diseases
- HIV Research and Treatment
University of Wisconsin–Madison
2016-2024
Indiana University – Purdue University Indianapolis
2023
Indiana University School of Medicine
2023
University of Minnesota
2022
University of Minnesota Medical Center
2021
Office of the Director
2020
Center for Cancer Research
2013
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, and neuroprotective or disease-modifying interventions remain elusive. High-throughput markers aimed at stratifying patients on basis of shared etiology are required to ensure success therapies in clinical trials. Mitochondrial dysfunction plays a prominent role pathogenesis PD. Previously, we found brain region–specific accumulation mitochondrial DNA (mtDNA) damage PD neuronal culture animal models, as well...
Epstein-Barr virus (EBV) is a ubiquitous human pathogen, infecting up to 95% of the world’s adult population. Initial infection with EBV can cause infectious mononucleosis.
Abstract Human infections caused by viral pathogens trigger a complex gamut of host responses that limit disease, resolve infection, generate immunity, and contribute to severe disease or death. Here, we present experimental methods multi-omics data capture approaches representing the global response infection generated from 45 individual experiments involving human viruses Orthomyxoviridae , Filoviridae Flaviviridae Coronaviridae families. Analogous designs were implemented across mouse...
The West African outbreak of Ebola virus (EBOV) is largely contained, but sporadic new cases continue to emerge. To assess the potential contribution fomites human infections with EBOV, we tested EBOV stability in blood spotted onto Sierra Leonean banknotes and syringe needles under hospital environmental conditions. Under some these conditions, remained infectious for >30 days, indicating that EBOV-contaminated items may pose a serious risk humans.
Abstract Assuring the safety of both patients and healthcare workers (HCWs) in hospitals has been primary focus every organization during COVID 19 pandemic. This article discusses NIH Clinical Center’s interdisciplinary approach to deploying an organizational Asymptomatic Staff Testing System.
ABSTRACT Innate immunity is protective against viruses, but also can facilitate pathological infection responses. Despite intensive research, our understanding of the mechanisms that regulate innate in virus remains incomplete. Systems biology-based data-driven modeling approaches hold substantial promise toward discovery crucial immune signaling regulators, yet model-derived predictions are almost completely unexplored. Here, we carried out systematic experimental validation candidate...