A5057572887- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Food Security and Health in Diverse Populations
- Immune cells in cancer
- Obesity, Physical Activity, Diet
- Child Nutrition and Water Access
University of Utah
2020-2023
Chicago Department of Public Health
2023
University of Illinois Chicago
2023
In response to various types of infection, naïve CD4
Following viral clearance, antigen-specific CD4+ T cells contract and form a pool of distinct Th1 Tfh memory that possess unique epigenetic programs, allowing them to rapidly recall their specific effector functions upon rechallenge. DNA methylation programing mediated by the methylcytosine dioxygenase Tet2 contributes balancing cell differentiation during acute infection; however, role in formation is unclear. Using adoptive transfer models wild type knockout cells, we find required for...
To identify recommendations to improve access and retention in the Child Adult Care Food Program (CACFP) as critical strategies address health equity for low-income children.
Abstract In response to viral infection, antigen-specific CD4 T cells differentiate into Th1 and follicular helper (Tfh) cell subsets that acquire distinct DNA demethylation changes which act enforce their lineage commitment functions. Following clearance, the populations of Tfh contract form memory maintain specific methylation programming. Previously, we found deficiency Tet2, an oxygenase mediates CpG demethylation, skews balance at 7 days post infection leading formation significantly...