A5080949854- Peptidase Inhibition and Analysis
- Biosimilars and Bioanalytical Methods
- Protease and Inhibitor Mechanisms
- Pharmacogenetics and Drug Metabolism
- Pharmaceutical studies and practices
- Cardiac Structural Anomalies and Repair
- Intracerebral and Subarachnoid Hemorrhage Research
- Pharmacological Effects and Toxicity Studies
- Treatment of Major Depression
- Receptor Mechanisms and Signaling
Sunshine Hospital
2025
Chongqing Medical University
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Southwest Medical University
2021-2022
22011 is an insulin degludec/insulin aspart co-formulation (IDegAsp) that shares identical amino acid sequence with Ryzodeg, the originator IDegAsp. This study aimed to compare pharmacokinetics (PK), pharmacodynamics (PD), and safety of 22,011 Ryzodeg. In a single-center, randomized, open-label, two-treatment, two-period, two-sequence, crossover, euglycemic clamp study, healthy Chinese adults were randomized receive 0.5 U/kg Ryzodeg under fasting conditions. PK was evaluated for up 120 hours...
Purpose HEC113995PA·H 2 O is a novel, potent and selective serotonin (5-HT) reuptake inhibitor 5-HT1A receptor partial agonist, thus categorized as agonist-reuptake inhibitor. The objective of this study was to evaluate the safety, tolerability, pharmacokinetics in healthy subjects after single multiple dosing, well food effect on safety O. Methods entire comprised three parts: Part I (single ascending-dose study), II (food III (multiple study). A total 121 were enrolled study. tablet or...
Abstract This study aimed to evaluate the pharmacokinetics (PKs), safety, and immunogenicity of biosimilar HEC14028 compared reference Trulicity® (dulaglutide) in healthy male Chinese subjects. was a single‐center, randomized, open, single‐dose, parallel‐controlled comparative Phase I clinical trial, including screening period up 14 days, 17‐day observation after administration, 7‐day safety follow‐up period. A total 68 subjects were randomly assigned (1:1) test group (HEC14028) (single 0.75...
Abstract Background Previous studies have showed the beneficial effects of mesenchymal stem cells (MSCs) on experimental intracerebral hemorrhage (ICH) animal. Enhancement treatment efficacy MSCs in ICH is essential, considering diseases association with high rates disability and mortality. Some auxiliary methods to enhance been introduced. However, effect electroacupuncture (EA) therapeutic transplantation hemorrhagic stroke its potential mechanism not explored. Methods rat models were...
Abstract Purpose To compare the detection performance of 68 Ga-DOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT) and 18 F-FDG PET/CT for patients with various benign diseases that 99m Tc-MDP single-photon computed (SPECT/CT) bone lesions. Methods In total, 111 underwent two types radionuclide examination. This prospective study included 89 who 22 SPECT/CT from January 2020 to June 2022. The lesion number, T value, B value were recorded calculate true positive rate T/B...