A5017844436- Malaria Research and Control
- Signaling Pathways in Disease
- Computational Drug Discovery Methods
- Occupational Health and Performance
- Neuroblastoma Research and Treatments
- Air Quality and Health Impacts
- Biomarkers in Disease Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Per- and polyfluoroalkyl substances research
- Cancer Research and Treatment
- Climate Change and Health Impacts
- interferon and immune responses
- Hydrogen's biological and therapeutic effects
- Research on Leishmaniasis Studies
- Phytochemical Studies and Bioactivities
- Phytochemistry and Bioactive Compounds
- Pancreatic function and diabetes
- Natural product bioactivities and synthesis
- Toxic Organic Pollutants Impact
- Peptidase Inhibition and Analysis
- FOXO transcription factor regulation
- Adipose Tissue and Metabolism
- vaccines and immunoinformatics approaches
University of Arizona
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
China Academy of Chinese Medical Sciences
2022
Guangdong Pharmaceutical University
2022
Firefighters face regular exposure to known and probable human carcinogens, such as polycyclic aromatic hydrocarbons (PAHs), benzene, formaldehyde, leading an increased risk of various cancers compared the general population. Hispanic black firefighters are at additional not elevated in non-Hispanic white firefighters, yet biological pathways underlying these differences unknown. The study objectives were evaluate urinary metabolome between pre-and post-fireground exposure. To investigate...
The occupation of firefighting is classified as a Group 1 carcinogen. Increased cancer risk among firefighters may be partly attributable to increased occupational exposure range chemicals, including per- and polyfluoroalkyl substances (PFAS). Some PFAS are known suspect human carcinogens. Investigating epigenetic response these exposures in help identify biological pathways specific cancers, previously unidentified health outcomes that associated with PFAS. We therefore investigated the...
Malaria parasites induce morphological and biochemical changes in the membranes of parasite-infected red blood cells (iRBCs) for propagation, with artemisinin combination therapies as first-line treatments. To understand whether targets or interacts iRBC membrane proteins, this study investigated molecular caused by dihydroartemisinin (DHA), an derivative, Plasmodium falciparum 3D7 using a combined transcriptomic proteomic profiling approach.
Abstract Background Neuroblastoma (NB) is a malignant pediatric tumor requiring new therapies. Accumulating evidence has confirmed that microRNAs play critical roles in NB metastasis. Dihydroartemisinin (DHA) capable of inhibiting the growth cells. The primary objective current investigation was to characterize newly discovered microRNA, miR-32-5p, terms functional role, underlying mechanism action, and potential synergistic therapeutic impact context Materials methods Real-time quantitative...
There was an investigation into the hypoglycemic effects and potential mechanisms of dihydroartemisinin (DHA) on hepatic glycometabolism type 2 diabetes mellitus (T2DM). The db/db mice ApoE −/− induced by streptozotocin (STZ) were selected as models. levels FBG, body weight, glucose tolerance, insulin, alanine aminotransferase (ALT), aspartate (AST) observed to evaluate drug’s efficacy. glycogen content, glucose-6-phosphate (G6P), hexokinase (HK) glucose-6-phosphatase (G6pase) detected in...
Abstract Neuroblastoma (NB) is a malignant pediatric tumor requiring new treatments. Accumulating evidence has confirmed that microRNAs (miRNAs) have major effect on NB metastasis. The present study aimed to characterize novel miRNA, miR-32-5p, by exploring its expression, function, as well action mechanism in Real-time quantitative polymerase chain reaction (qRT-PCR) Western blotting was utilized measure the expression of miR-32-5p and target-vacuolar protein sorting 4B (VPS4B). Transwell...