A5034648676- SARS-CoV-2 and COVID-19 Research
- Occupational Health and Performance
- Toxic Organic Pollutants Impact
- COVID-19 Clinical Research Studies
- Environmental Toxicology and Ecotoxicology
- Per- and polyfluoroalkyl substances research
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Epigenetics and DNA Methylation
- SARS-CoV-2 detection and testing
- Injury Epidemiology and Prevention
- Pregnancy-related medical research
- Infection Control and Ventilation
- Respiratory viral infections research
- Pharmaceutical and Antibiotic Environmental Impacts
- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Animal Virus Infections Studies
- Reproductive biology and impacts on aquatic species
- Birth, Development, and Health
- Viral gastroenteritis research and epidemiology
- vaccines and immunoinformatics approaches
- Adipose Tissue and Metabolism
- Spaceflight effects on biology
- Water Treatment and Disinfection
University of Arizona
2018-2025
University of Miami
2022
Rocky Mountain University of Health Professions
2022
University of Utah
2022
University of Saskatchewan
2012-2021
Western Texas College
2020
Jungheinrich (Germany)
2020
Messenger RNA (mRNA) BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) COVID-19 vaccines have been shown to be effective in preventing symptomatic randomized placebo-controlled Phase III trials (1,2); however, the benefits of these for asymptomatic SARS-CoV-2 (the virus that causes COVID-19) infection, particularly when administered real-world conditions, is less well understood. Using prospective cohorts health care personnel, first responders, other essential frontline workers* eight U.S....
Information is limited regarding the effectiveness of two-dose messenger RNA (mRNA) vaccines BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) in preventing infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attenuating disease 2019 (Covid-19) when administered real-world conditions.
The BNT162b2 (Pfizer-BioNTech) mRNA COVID-19 vaccine was recommended by CDC's Advisory Committee on Immunization Practices for persons aged 12-15 years (referred to as adolescents in this report) May 12, 2021, and children 5-11 November 2, 2021 (1-4). Real-world data effectiveness (VE) these age groups are needed, especially because when the B.1.1.529 (Omicron) variant became predominant United States December early investigations of VE demonstrated a decline protection against symptomatic...
The Arizona Healthcare, Emergency Response, and Other Essential workers Study (AZ HEROES) aims to examine the epidemiology of SARS-CoV-2 infection COVID-19 illness among adults with high occupational exposure risk.
Background: Per- and polyfluoroalkyl substances (PFASs) are persistent chemicals that firefighters encounter. Epigenetic modifications, including DNA methylation, could serve as PFASs toxicity biomarkers. Methods: With a sample size of 197 firefighters, we quantified the serum concentrations nine PFASs, blood leukocyte methylation epigenetic age indicators via EPIC array. We examined associations between with age, site- region-specific adjusting for confounders. Results: Perfluorohexane...
Firefighters have occupational and environmental exposures to per- polyfluoroalkyl substances (PFAS). The goal of this study was compare serum PFAS concentrations across multiple United States fire departments National Health Nutrition Examination Survey (NHANES) participants.Nine were compared in 290 firefighters from four municipal (coded A-D) three NHANES participants matched each firefighter on sex, ethnicity, age, collection year. Only Departments A C had sufficient women (25 six,...
Abstract Background Firefighters have increased cancer incidence and mortality rates compared to the general population, are exposed multiple products of combustion including known suspected carcinogens. Objective The study objective was quantify fire response exposures by role self-reported exposure risks. Methods Urinary hydroxylated metabolites polycyclic aromatic hydrocarbons (PAH-OHs) were measured at baseline 2–4 h after structural fires post-fire surveys collected. Results Baseline...
Prostate cancer is the leading incident among men in United States. Firefighters are diagnosed with this disease at a rate 1.21 times higher than average population. This increased risk may result from occupational exposures to many toxicants, including per- and polyfluoroalkyl substances (PFAS). study assessed association between firefighting as an occupation general or PFAS serum levels, DNA methylation. Only genomic regions previously linked prostate were selected for analysis: GSTP1, Alu...
Dioxin-like compounds (DLCs) are pollutants of global environmental concern. DLCs elicit their adverse outcomes through activation the aryl hydrocarbon receptor (AhR). However, there is limited understanding mechanisms that result in differences sensitivity to among different species fishes. Understanding these critical for protection diversity fishes exposed DLCs, including endangered species. This study investigated specific drive responses two fishes, white sturgeon (Acipenser...
Sensitivity of white sturgeon (Acipenser transmontanus) to copper (Cu) or cadmium (Cd) has been shown significantly differ as a function life-stage. This study investigated oxidative stress, metal homeostasis, and associated compensatory responses potential mechanisms this sensitivity pattern in three early life-stages. Sturgeon were most sensitive Cu at 15 days post hatch (dph), which was accompanied by significant increase lipid peroxidation (LPO). Genes involved with amelioration stress...
Per- and polyfluoroalkyl substances (PFAS) are ubiquitous throughout the United States. Previous studies have shown PFAS exposure to be associated with a reduced immune response. However, relationship between serum antibody levels following SARS-CoV-2 infection or COVID-19 vaccination has not been examined. We examined differences in peak response longitudinal decline of antibodies by cohort essential workers measured using an in-house semi-quantitative enzyme-linked immunosorbent assay...
ABSTRACT Wildland–urban interface (WUI) firefighting involves exposure to burning vegetation, structures, and other human‐made hazards, often without respiratory protection. Response activities can last for long periods of time, spanning multiple days or weeks. Epigenetic modifications, including microRNA (miRNA) expression DNA methylation, are responsive toxicant exposures part the development cancers diseases. modifications have not been studied in relation WUI fires. Firefighters ( n =...
Firefighters face regular exposure to known and probable human carcinogens, such as polycyclic aromatic hydrocarbons (PAHs), benzene, formaldehyde, leading an increased risk of various cancers compared the general population. Hispanic black firefighters are at additional not elevated in non-Hispanic white firefighters, yet biological pathways underlying these differences unknown. The study objectives were evaluate urinary metabolome between pre-and post-fireground exposure. To investigate...
Firefighters can be exposed to a complex set of contaminants while at fire scene. Identifying new ways monitor and assess exposure, particularly relating toxicity is essential determine the effectiveness intervention techniques reduce exposure. This study investigated use polycyclic aromatic hydrocarbon (PAH) CALUX® bioassay for assessment exposure associated firefighters might encounter. was done through analysis extracts dermal wipes urine samples collected from before after controlled...
Workers critical to emergency response and continuity of essential services during the COVID-19 pandemic are at a disproportionally high risk SARS-CoV-2 infection. Prospective cohort studies needed for enhancing understanding incidence symptomatic asymptomatic infections, identifying factors, assessing clinical outcomes, determining effectiveness vaccination.The Research on Epidemiology in Essential Response Personnel (RECOVER) prospective study was designed estimate examine factors...
Objective The aim of the study is to examine associations between years firefighting service and eight chronological age-adjusted measures blood leukocyte epigenetic age acceleration: Horvath, Hannum, SkinBloodClock, Intrinsic, Extrinsic, PhenoAge, GrimAge, DNAm telomere length. Methods used a repeated analysis data from 379 incumbent firefighters career departments 100 recruit two departments, across United States. Results Incumbent had on average greater acceleration compared with...
Certain occupations have greater risk for per- and polyfluoroalkyl substances (PFAS) exposure because of PFAS use in occupation-associated materials. We sought to assess whether concentrations differed by occupation among certain Arizona workers over time occupation. Serum 14 were measured 1960 Healthcare, Emergency Responder, Other Essential Worker Study participants. Samples collected at enrollment periodically during July 2020-April 2023. Occupational categories included firefighters,...
The occupation of firefighting is classified as a Group 1 carcinogen. Increased cancer risk among firefighters may be partly attributable to increased occupational exposure range chemicals, including per- and polyfluoroalkyl substances (PFAS). Some PFAS are known suspect human carcinogens. Investigating epigenetic response these exposures in help identify biological pathways specific cancers, previously unidentified health outcomes that associated with PFAS. We therefore investigated the...
Abstract Background Dysregulated microRNA (miRNA) expression could provide a mechanism linking firefighter exposure to increased cancer risk. Objective To determine if changes in longitudinal miRNA firefighters are associated with occupational exposures. Methods Whole blood MiRNA was evaluated 52 new recruits prior live-fire training and 20–37 months later. Linear mixed effects models adjusted for age, ethnicity, BMI, batch were used associations separately all fires structure only between...