A5067597704- RNA Research and Splicing
- Chronic Myeloid Leukemia Treatments
- Ectopic Pregnancy Diagnosis and Management
- Maternal and fetal healthcare
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Molecular Communication and Nanonetworks
- Inflammasome and immune disorders
- Circular RNAs in diseases
- Reproductive Health and Contraception
- Gout, Hyperuricemia, Uric Acid
- Innovative Microfluidic and Catalytic Techniques Innovation
- Endometrial and Cervical Cancer Treatments
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai Institute of Hematology
2024
Liaoning Cancer Hospital & Institute
2024
Dalian University of Technology
2024
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
Abstract Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies improve AML patient outcomes. Herein, we retrospectively analyzed multiomics data of more than 1,500 cases and found that patients spliceosome mutations had higher risk developing disease. RNA splicing analysis revealed mis-spliced genes in converged on translation-associated pathways, promoted...
子宫内膜癌是女性生殖系统三大恶性肿瘤之一。在欧美国家，子宫内膜癌的发病率已居女性生殖系统恶性肿瘤的首位，在我国也呈现上升趋势。如何在人群中筛选出子宫内膜癌前病变及早期子宫内膜癌，提高子宫内膜癌的筛查效率，实现子宫内膜癌的早发现、早诊断、早治疗，已势在必行。本建议根据我国子宫内膜癌的诊治经验及筛查现状，结合国际筛查指南及国内外文献，经过中国医师协会妇产科学分会各位专家多次讨论，对于子宫内膜癌的筛查及早期诊断达成了新的规范建议。.
To establish and validate a predicting nomogram for cervical adenocarcinoma based on surveillance, epidemiology end results (SEER) database Chinese single-center data, to explore the optimal treatment adenocarcinoma.
<div>Abstract<p>Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies improve AML patient outcomes. Herein, we retrospectively analyzed multiomics data of more than 1,500 cases and found that patients spliceosome mutations had higher risk developing disease. RNA splicing analysis revealed mis-spliced genes in converged on translation-associated...
<div>Abstract<p>Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies improve AML patient outcomes. Herein, we retrospectively analyzed multiomics data of more than 1,500 cases and found that patients spliceosome mutations had higher risk developing disease. RNA splicing analysis revealed mis-spliced genes in converged on translation-associated...
<p>Supplementary methods and Figure S1-S12</p>
Synthesizable molecular design (also known as synthesizable optimization) is a fundamental problem in drug discovery, and involves designing novel structures to improve their properties according drug-relevant oracle functions (i.e., objective) while ensuring synthetic feasibility. However, existing methods are mostly based on random search. To address this issue, paper, we introduce approach using the reinforcement learning method with quantum-inspired simulated annealing policy neural...
<p>Supplementary methods and Figure S1-S12</p>