A5029575789- RNA Research and Splicing
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Banana Cultivation and Research
- RNA modifications and cancer
- Agricultural Practices and Plant Genetics
- Single-cell and spatial transcriptomics
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
Ruijin Hospital
2024-2025
Shanghai Institute of Hematology
2024-2025
Shanghai Jiao Tong University
2024-2025
Abstract Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies improve AML patient outcomes. Herein, we retrospectively analyzed multiomics data of more than 1,500 cases and found that patients spliceosome mutations had higher risk developing disease. RNA splicing analysis revealed mis-spliced genes in converged on translation-associated pathways, promoted...
Although advancements in genomic and epigenetic research have deepened our understanding of acute myeloid leukemia (AML), only one-third patients can achieve durable remission. Growing evidence suggests that the immune microenvironment bone marrow influences prognosis survival AML. There is a specific association between CD8
Acute myeloid leukemia (AML) has lagged in benefiting from immunotherapies, primarily due to the scarcity of actionable AML-specific antigens. Driver mutations represent promising immunogenic targets, but a comprehensive characterization AML neoantigen landscape and their impact on patient outcomes immune microenvironment remain unclear. Herein, we conducted matched DNA RNA sequencing 304 patients extensively integrated data additional ∼2,500 cases, identifying 49 driver genes, notably...
<div>Abstract<p>Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies improve AML patient outcomes. Herein, we retrospectively analyzed multiomics data of more than 1,500 cases and found that patients spliceosome mutations had higher risk developing disease. RNA splicing analysis revealed mis-spliced genes in converged on translation-associated...
<div>Abstract<p>Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies improve AML patient outcomes. Herein, we retrospectively analyzed multiomics data of more than 1,500 cases and found that patients spliceosome mutations had higher risk developing disease. RNA splicing analysis revealed mis-spliced genes in converged on translation-associated...
<p>Supplementary methods and Figure S1-S12</p>
<p>Supplementary methods and Figure S1-S12</p>