A5022194507- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Cancer Genomics and Diagnostics
- Synthesis and Biological Evaluation
EpiCypher (United States)
2024
Georgia State University
1998
During tumor development, promoter CpG islands that are normally silenced by Polycomb repressive complexes (PRCs) become DNA-hypermethylated. The molecular mechanism which de novo DNA methyltransferase(s) [DNMT(s)] catalyze methylation at PRC-regulated regions remains unclear. Here, we report a cryo-electron microscopy structure of the DNMT3A long isoform (DNMT3A1) amino-terminal region in complex with nucleosome carrying PRC1-mediated histone H2A lysine-119 monoubiquitination (H2AK119Ub)....
The precise regulation of chromatin composition is critical to gene expression and cellular identity, thus a key component in development disease. Robust assays study features, including histone post-translational modifications (PTMs) chromatin-associated proteins (e.g., transcription factors or PTM readers), are essential understand their function identify novel therapeutic strategies. To this end, Cleavage Under Targets Release Using Nuclease (CUT&RUN) has emerged as powerful tool for...
During tumor development, promoter CpG islands (CGIs) that are normally silenced by Polycomb repressive complexes (PRCs) become DNA hypermethylated. The molecular mechanism which
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